Decreased, Deformed, Defective—How HIV-1 Vpu Targets Peroxisomes

ABSTRACT Peroxisomes are found in essentially all eukaryotic cells and have been described as important hubs in innate sensing and the induction of type III interferons upon viral infection. Nevertheless, it remains poorly investigated how viral pathogens modulate biogenesis or function of peroxisom...

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Autores principales:	Kristina Hopfensperger, Daniel Sauter
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	Vpu human immunodeficiency virus miRNA peroxisomes Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/85be1aa47fe04b6e9c49005afbcf0fd4
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spelling	oai:doaj.org-article:85be1aa47fe04b6e9c49005afbcf0fd42021-11-15T15:56:47ZDecreased, Deformed, Defective—How HIV-1 Vpu Targets Peroxisomes10.1128/mBio.00967-202150-7511https://doaj.org/article/85be1aa47fe04b6e9c49005afbcf0fd42020-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00967-20https://doaj.org/toc/2150-7511ABSTRACT Peroxisomes are found in essentially all eukaryotic cells and have been described as important hubs in innate sensing and the induction of type III interferons upon viral infection. Nevertheless, it remains poorly investigated how viral pathogens modulate biogenesis or function of peroxisomes to evade innate sensing and restriction. In a recent study, Hobman and colleagues found that the accessory viral protein u (Vpu) of HIV-1 inhibits peroxisome activity by depleting cellular peroxisome pools. This depletion could be ascribed to a Vpu-dependent induction of four microRNAs (miRNAs) that suppress the expression of peroxisomal biogenesis factors PEX2, PEX7, PEX11B, and PEX13. Although the downstream effects on antiretroviral gene expression and HIV-1 replication remain to be determined, these findings provide important insights into peroxisome biogenesis and the modulation of cell organelles by HIV-1 Vpu.Kristina HopfenspergerDaniel SauterAmerican Society for MicrobiologyarticleVpuhuman immunodeficiency virusmiRNAperoxisomesMicrobiologyQR1-502ENmBio, Vol 11, Iss 3 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Vpu human immunodeficiency virus miRNA peroxisomes Microbiology QR1-502
spellingShingle	Vpu human immunodeficiency virus miRNA peroxisomes Microbiology QR1-502 Kristina Hopfensperger Daniel Sauter Decreased, Deformed, Defective—How HIV-1 Vpu Targets Peroxisomes
description	ABSTRACT Peroxisomes are found in essentially all eukaryotic cells and have been described as important hubs in innate sensing and the induction of type III interferons upon viral infection. Nevertheless, it remains poorly investigated how viral pathogens modulate biogenesis or function of peroxisomes to evade innate sensing and restriction. In a recent study, Hobman and colleagues found that the accessory viral protein u (Vpu) of HIV-1 inhibits peroxisome activity by depleting cellular peroxisome pools. This depletion could be ascribed to a Vpu-dependent induction of four microRNAs (miRNAs) that suppress the expression of peroxisomal biogenesis factors PEX2, PEX7, PEX11B, and PEX13. Although the downstream effects on antiretroviral gene expression and HIV-1 replication remain to be determined, these findings provide important insights into peroxisome biogenesis and the modulation of cell organelles by HIV-1 Vpu.
format	article
author	Kristina Hopfensperger Daniel Sauter
author_facet	Kristina Hopfensperger Daniel Sauter
author_sort	Kristina Hopfensperger
title	Decreased, Deformed, Defective—How HIV-1 Vpu Targets Peroxisomes
title_short	Decreased, Deformed, Defective—How HIV-1 Vpu Targets Peroxisomes
title_full	Decreased, Deformed, Defective—How HIV-1 Vpu Targets Peroxisomes
title_fullStr	Decreased, Deformed, Defective—How HIV-1 Vpu Targets Peroxisomes
title_full_unstemmed	Decreased, Deformed, Defective—How HIV-1 Vpu Targets Peroxisomes
title_sort	decreased, deformed, defective—how hiv-1 vpu targets peroxisomes
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/85be1aa47fe04b6e9c49005afbcf0fd4
work_keys_str_mv	AT kristinahopfensperger decreaseddeformeddefectivehowhiv1vputargetsperoxisomes AT danielsauter decreaseddeformeddefectivehowhiv1vputargetsperoxisomes
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Decreased, Deformed, Defective—How HIV-1 Vpu Targets Peroxisomes

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