Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes
ABSTRACT Certain “protective” major histocompatibility complex class I (MHC-I) alleles, such as B*57 and B*27, are associated with long-term control of HIV-1 in vivo mediated by the CD8+ cytotoxic-T-lymphocyte (CTL) response. However, the mechanism of such superior protection is not fully understood...
Saved in:
Main Authors: | Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, Ren Sun |
---|---|
Format: | article |
Language: | EN |
Published: |
American Society for Microbiology
2017
|
Subjects: | |
Online Access: | https://doaj.org/article/85c05c9d6e2845998b33493d2d33d8ed |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Review and Perspectives on the Structure–Function Relationships of the Gag Subunits of Feline Immunodeficiency Virus
by: Mathieu Long, et al.
Published: (2021) -
Distinct Pathway of Human T-Cell Leukemia Virus Type 1 Gag Punctum Biogenesis Provides New Insights into Enveloped Virus Assembly
by: John P. Eichorst, et al.
Published: (2018) -
Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern
by: Antonio J. Martín-Galiano, et al.
Published: (2021) -
Visualizing Association of the Retroviral Gag Protein with Unspliced Viral RNA in the Nucleus
by: Rebecca J. Kaddis Maldonado, et al.
Published: (2020) -
ESCAPE CLAUSES AND TARGETING OF THE REAL EXCHANGE RATE: THE CASE OF NOMINAL EXCHANGE RATE PEGGING
by: GONZALEZ M,PABLO
Published: (2010)