Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes

Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes

ABSTRACT Certain “protective” major histocompatibility complex class I (MHC-I) alleles, such as B*57 and B*27, are associated with long-term control of HIV-1 in vivo mediated by the CD8+ cytotoxic-T-lymphocyte (CTL) response. However, the mechanism of such superior protection is not fully understood...

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Main Authors: Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, Ren Sun
Format: article
Language:EN
Published: American Society for Microbiology 2017
Subjects:
CTL escape
Gag epitopes
HIV-I
high-throughput fitness profiling
MHC binding prediction
intrapatient viral evolution
Microbiology
QR1-502
Online Access:https://doaj.org/article/85c05c9d6e2845998b33493d2d33d8ed
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https://doaj.org/article/85c05c9d6e2845998b33493d2d33d8ed

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