Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma

Johannes Baur,1 Christian O Ritter,2 Christoph-Thomas Germer,1 Ingo Klein,1 Ralph Kickuth,2 Ulrich Steger,1 1Department of General, Visceral, Vascular, and Pediatric Surgery, 2Institute of Radiology, University Hospital Würzburg, Würzburg, Germany Purpose: In hepatocellular carcin...

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Autores principales:	Baur J, Ritter CO, Germer CT, Klein I, Kickuth R, Steger U
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Transarterial Chemoembolisation Hepatocellular Carcinoma Drug Eluting Beads Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/85c18b34a0df48ff8106e3f8cb215412
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spelling	oai:doaj.org-article:85c18b34a0df48ff8106e3f8cb2154122021-12-02T04:38:41ZTransarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma1179-1535https://doaj.org/article/85c18b34a0df48ff8106e3f8cb2154122016-06-01T00:00:00Zhttps://www.dovepress.com/transarterial-chemoembolization-with-drug-eluting-beads-versus-convent-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535Johannes Baur,1 Christian O Ritter,2 Christoph-Thomas Germer,1 Ingo Klein,1 Ralph Kickuth,2 Ulrich Steger,1 1Department of General, Visceral, Vascular, and Pediatric Surgery, 2Institute of Radiology, University Hospital Würzburg, Würzburg, Germany Purpose: In hepatocellular carcinoma patients with large or multinodal tumors, where curative treatment options are not feasible, transarterial therapies play a major role. Transarterial chemoembolization (TACE) with drug-eluting beads (DEB-TACE) is a promising new approach due to higher intratumoral and lower systemic concentration of the chemotherapeutic agent compared to conventional TACE (cTACE). Patients and methods: In a retrospective analysis, 32 patients with hepatocellular carcinoma who received either DEB or a cTACE were compared regarding survival time, disease recurrence, and side effects such as pain and fever. Results: No significant differences could be detected between the cTACE and DEB-TACE groups with regard to mean hospital stay, appearance of postinterventional fever, or 30-day mortality. However, the application of intravenous analgesics as postinterventional pain medication was needed more often in patients treated with DEB-TACE (57.1% vs 12.5%, P=0.0281). The overall median survival after the initial procedure was 10.8 months in the cTACE group and 9.2 months in the DEB-TACE group, showing no significant difference. Conclusion: No survival benefit for patients treated with either DEB-TACE or cTACE was observed. Surprisingly, a higher rate of postinterventional pain could be detected after DEB-TACE. Keywords: transarterial chemoembolization, hepatocellular carcinoma, drug-eluting beadsBaur JRitter COGermer CTKlein IKickuth RSteger UDove Medical PressarticleTransarterial ChemoembolisationHepatocellular CarcinomaDrug Eluting BeadsDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol 2016, Iss Issue 1, Pp 69-74 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Transarterial Chemoembolisation Hepatocellular Carcinoma Drug Eluting Beads Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Transarterial Chemoembolisation Hepatocellular Carcinoma Drug Eluting Beads Diseases of the digestive system. Gastroenterology RC799-869 Baur J Ritter CO Germer CT Klein I Kickuth R Steger U Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma
description	Johannes Baur,1 Christian O Ritter,2 Christoph-Thomas Germer,1 Ingo Klein,1 Ralph Kickuth,2 Ulrich Steger,1 1Department of General, Visceral, Vascular, and Pediatric Surgery, 2Institute of Radiology, University Hospital Würzburg, Würzburg, Germany Purpose: In hepatocellular carcinoma patients with large or multinodal tumors, where curative treatment options are not feasible, transarterial therapies play a major role. Transarterial chemoembolization (TACE) with drug-eluting beads (DEB-TACE) is a promising new approach due to higher intratumoral and lower systemic concentration of the chemotherapeutic agent compared to conventional TACE (cTACE). Patients and methods: In a retrospective analysis, 32 patients with hepatocellular carcinoma who received either DEB or a cTACE were compared regarding survival time, disease recurrence, and side effects such as pain and fever. Results: No significant differences could be detected between the cTACE and DEB-TACE groups with regard to mean hospital stay, appearance of postinterventional fever, or 30-day mortality. However, the application of intravenous analgesics as postinterventional pain medication was needed more often in patients treated with DEB-TACE (57.1% vs 12.5%, P=0.0281). The overall median survival after the initial procedure was 10.8 months in the cTACE group and 9.2 months in the DEB-TACE group, showing no significant difference. Conclusion: No survival benefit for patients treated with either DEB-TACE or cTACE was observed. Surprisingly, a higher rate of postinterventional pain could be detected after DEB-TACE. Keywords: transarterial chemoembolization, hepatocellular carcinoma, drug-eluting beads
format	article
author	Baur J Ritter CO Germer CT Klein I Kickuth R Steger U
author_facet	Baur J Ritter CO Germer CT Klein I Kickuth R Steger U
author_sort	Baur J
title	Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma
title_short	Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma
title_full	Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma
title_fullStr	Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma
title_full_unstemmed	Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma
title_sort	transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/85c18b34a0df48ff8106e3f8cb215412
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Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma

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