An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides

HDAC3 is a critical mediator of hepatic lipid metabolism and its loss leads to fatty liver. Here, the authors characterize the liver HDAC3 interactome in vivo, provide evidence that HDAC3 interacts with PROX1, and show that HDAC3 and PROX1 control expression of genes regulating lipid homeostasis.

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Autores principales:	Sean M. Armour, Jarrett R. Remsberg, Manashree Damle, Simone Sidoli, Wesley Y. Ho, Zhenghui Li, Benjamin A. Garcia, Mitchell A. Lazar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85c3dd24e5854aa9a44f1cb3cdbc9f58
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spelling	oai:doaj.org-article:85c3dd24e5854aa9a44f1cb3cdbc9f582021-12-02T14:42:25ZAn HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides10.1038/s41467-017-00772-52041-1723https://doaj.org/article/85c3dd24e5854aa9a44f1cb3cdbc9f582017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00772-5https://doaj.org/toc/2041-1723HDAC3 is a critical mediator of hepatic lipid metabolism and its loss leads to fatty liver. Here, the authors characterize the liver HDAC3 interactome in vivo, provide evidence that HDAC3 interacts with PROX1, and show that HDAC3 and PROX1 control expression of genes regulating lipid homeostasis.Sean M. ArmourJarrett R. RemsbergManashree DamleSimone SidoliWesley Y. HoZhenghui LiBenjamin A. GarciaMitchell A. LazarNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sean M. Armour Jarrett R. Remsberg Manashree Damle Simone Sidoli Wesley Y. Ho Zhenghui Li Benjamin A. Garcia Mitchell A. Lazar An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides
description	HDAC3 is a critical mediator of hepatic lipid metabolism and its loss leads to fatty liver. Here, the authors characterize the liver HDAC3 interactome in vivo, provide evidence that HDAC3 interacts with PROX1, and show that HDAC3 and PROX1 control expression of genes regulating lipid homeostasis.
format	article
author	Sean M. Armour Jarrett R. Remsberg Manashree Damle Simone Sidoli Wesley Y. Ho Zhenghui Li Benjamin A. Garcia Mitchell A. Lazar
author_facet	Sean M. Armour Jarrett R. Remsberg Manashree Damle Simone Sidoli Wesley Y. Ho Zhenghui Li Benjamin A. Garcia Mitchell A. Lazar
author_sort	Sean M. Armour
title	An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides
title_short	An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides
title_full	An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides
title_fullStr	An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides
title_full_unstemmed	An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides
title_sort	hdac3-prox1 corepressor module acts on hnf4α to control hepatic triglycerides
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/85c3dd24e5854aa9a44f1cb3cdbc9f58
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An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides

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