Total body irradiation causes a chronic decrease in antioxidant levels

Abstract Ionizing radiation exposure may not only cause acute radiation syndrome, but also an increased risk of late effects. It has been hypothesized that induction of chronic oxidative stress mediates the late effects of ionizing radiation. However, only a few reports have analyzed changes in long...

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Autores principales:	Lue Sun, Yohei Inaba, Yu Sogo, Atsuo Ito, Mahesh Bekal, Koichi Chida, Takashi Moritake
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/85c41161e0504b43aa930aa27a9abace
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spelling	oai:doaj.org-article:85c41161e0504b43aa930aa27a9abace2021-12-02T17:04:34ZTotal body irradiation causes a chronic decrease in antioxidant levels10.1038/s41598-021-86187-12045-2322https://doaj.org/article/85c41161e0504b43aa930aa27a9abace2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86187-1https://doaj.org/toc/2045-2322Abstract Ionizing radiation exposure may not only cause acute radiation syndrome, but also an increased risk of late effects. It has been hypothesized that induction of chronic oxidative stress mediates the late effects of ionizing radiation. However, only a few reports have analyzed changes in long-term antioxidant capacity after irradiation in vivo. Our previous study demonstrated changes in whole-blood antioxidant capacity and red blood cell (RBC) glutathione levels within 50 days after total body irradiation (TBI). In this study, seven-week-old, male, C57BL/6J mice exposed to total body irradiation by X-ray and changes in whole-blood antioxidant capacity and RBC glutathione levels at ≥ 100 days after TBI were investigated. Whole-blood antioxidant capacity was chronically decreased in the 5-Gy group. The RBC reduced glutathione (GSH) level and the GSH/oxidative glutathione (GSSG) ratio were chronically decreased after ≥ 1 Gy of TBI. Interestingly, the complete blood counts (CBC) changed less with 1-Gy exposure, suggesting that GSH and the GSH/GSSG ratio were more sensitive radiation exposure markers than whole-blood antioxidant capacity and CBC counts. It has been reported that GSH depletion is one of the triggers leading to cataracts, hypertension, and atherosclerosis, and these diseases are also known as radiation-induced late effects. The present findings further suggest that chronic antioxidant reduction may contribute to the pathogenesis of late radiation effects.Lue SunYohei InabaYu SogoAtsuo ItoMahesh BekalKoichi ChidaTakashi MoritakeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lue Sun Yohei Inaba Yu Sogo Atsuo Ito Mahesh Bekal Koichi Chida Takashi Moritake Total body irradiation causes a chronic decrease in antioxidant levels
description	Abstract Ionizing radiation exposure may not only cause acute radiation syndrome, but also an increased risk of late effects. It has been hypothesized that induction of chronic oxidative stress mediates the late effects of ionizing radiation. However, only a few reports have analyzed changes in long-term antioxidant capacity after irradiation in vivo. Our previous study demonstrated changes in whole-blood antioxidant capacity and red blood cell (RBC) glutathione levels within 50 days after total body irradiation (TBI). In this study, seven-week-old, male, C57BL/6J mice exposed to total body irradiation by X-ray and changes in whole-blood antioxidant capacity and RBC glutathione levels at ≥ 100 days after TBI were investigated. Whole-blood antioxidant capacity was chronically decreased in the 5-Gy group. The RBC reduced glutathione (GSH) level and the GSH/oxidative glutathione (GSSG) ratio were chronically decreased after ≥ 1 Gy of TBI. Interestingly, the complete blood counts (CBC) changed less with 1-Gy exposure, suggesting that GSH and the GSH/GSSG ratio were more sensitive radiation exposure markers than whole-blood antioxidant capacity and CBC counts. It has been reported that GSH depletion is one of the triggers leading to cataracts, hypertension, and atherosclerosis, and these diseases are also known as radiation-induced late effects. The present findings further suggest that chronic antioxidant reduction may contribute to the pathogenesis of late radiation effects.
format	article
author	Lue Sun Yohei Inaba Yu Sogo Atsuo Ito Mahesh Bekal Koichi Chida Takashi Moritake
author_facet	Lue Sun Yohei Inaba Yu Sogo Atsuo Ito Mahesh Bekal Koichi Chida Takashi Moritake
author_sort	Lue Sun
title	Total body irradiation causes a chronic decrease in antioxidant levels
title_short	Total body irradiation causes a chronic decrease in antioxidant levels
title_full	Total body irradiation causes a chronic decrease in antioxidant levels
title_fullStr	Total body irradiation causes a chronic decrease in antioxidant levels
title_full_unstemmed	Total body irradiation causes a chronic decrease in antioxidant levels
title_sort	total body irradiation causes a chronic decrease in antioxidant levels
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/85c41161e0504b43aa930aa27a9abace
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_version_	1718381859125067776

Total body irradiation causes a chronic decrease in antioxidant levels

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