Biodegradable Polymers for Gene-Delivery Applications

Chih-Kuang Chen,1 Ping-Kuan Huang,2 Wing-Cheung Law,3 Chia-Hui Chu,4 Nai-Tzu Chen,5 Leu-Wei Lo4 1Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan; 2Department of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Taiwan; 3...

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Autores principales:	Chen CK, Huang PK, Law WC, Chu CH, Chen NT, Lo LW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	gene therapy gene delivery non-viral vectors polymeric vectors biodegradable polymers Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/85ca5c11959d4028a0dad9e6b339cc55
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spelling	oai:doaj.org-article:85ca5c11959d4028a0dad9e6b339cc552021-12-02T09:32:27ZBiodegradable Polymers for Gene-Delivery Applications1178-2013https://doaj.org/article/85ca5c11959d4028a0dad9e6b339cc552020-03-01T00:00:00Zhttps://www.dovepress.com/biodegradable-polymers-for-gene-delivery-applications-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Chih-Kuang Chen,1 Ping-Kuan Huang,2 Wing-Cheung Law,3 Chia-Hui Chu,4 Nai-Tzu Chen,5 Leu-Wei Lo4 1Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan; 2Department of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Taiwan; 3Department of Industrial and Systems Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, People’s Republic of China; 4Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan 35053, Taiwan; 5Institute of New Drug Development, China Medical University, Taichung 40402, TaiwanCorrespondence: Chih-Kuang ChenDepartment of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, TaiwanTel +886-7-5252000 ext. 4060Fax +886-7-5254099Email chihkuan@mail.nsysu.edu.twLeu-Wei LoInstitute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan 35053, TaiwanTel +886-37-246166 ext. 37115Email lwlo@nhri.org.twAbstract: Gene-based therapies have emerged as a new modality for combating a myriad of currently incurable diseases. However, the fragile nature of gene therapeutics has significantly hampered their biomedical applications. Correspondingly, the development of gene-delivery vectors is of critical importance for gene-based therapies. To date, a variety of gene-delivery vectors have been created and utilized for gene delivery. In general, they can be categorized into viral- and non-viral vectors. Due to safety issues associated with viral vectors, non-viral vectors have recently attracted much more research focus. Of these non-viral vectors, polymeric vectors, which have been preferred due to their low immunogenicity, ease of production, controlled chemical composition and high chemical versatility, have constituted an ideal alternative to viral vectors. In particular, biodegradable polymers, which possess advantageous biocompatibility and biosafety, have been considered to have great potential in clinical applications. In this context, the aim of this review is to introduce the recent development and progress of biodegradable polymers for gene delivery applications, especially for their chemical structure design, gene delivery capacity and additional biological functions. Accordingly, we first define and categorize biodegradable polymers, followed by describing their corresponding degradation mechanisms. Various types of biodegradable polymers resulting from natural and synthetic polymers will be introduced and their applications in gene delivery will be examined. Finally, a future perspective regarding the development of biodegradable polymer vectors will be given.Keywords: gene therapy, gene delivery, non-viral vectors, polymeric vectors, biodegradable polymersChen CKHuang PKLaw WCChu CHChen NTLo LWDove Medical Pressarticlegene therapygene deliverynon-viral vectorspolymeric vectorsbiodegradable polymersMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 2131-2150 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	gene therapy gene delivery non-viral vectors polymeric vectors biodegradable polymers Medicine (General) R5-920
spellingShingle	gene therapy gene delivery non-viral vectors polymeric vectors biodegradable polymers Medicine (General) R5-920 Chen CK Huang PK Law WC Chu CH Chen NT Lo LW Biodegradable Polymers for Gene-Delivery Applications
description	Chih-Kuang Chen,1 Ping-Kuan Huang,2 Wing-Cheung Law,3 Chia-Hui Chu,4 Nai-Tzu Chen,5 Leu-Wei Lo4 1Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan; 2Department of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Taiwan; 3Department of Industrial and Systems Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, People’s Republic of China; 4Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan 35053, Taiwan; 5Institute of New Drug Development, China Medical University, Taichung 40402, TaiwanCorrespondence: Chih-Kuang ChenDepartment of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, TaiwanTel +886-7-5252000 ext. 4060Fax +886-7-5254099Email chihkuan@mail.nsysu.edu.twLeu-Wei LoInstitute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan 35053, TaiwanTel +886-37-246166 ext. 37115Email lwlo@nhri.org.twAbstract: Gene-based therapies have emerged as a new modality for combating a myriad of currently incurable diseases. However, the fragile nature of gene therapeutics has significantly hampered their biomedical applications. Correspondingly, the development of gene-delivery vectors is of critical importance for gene-based therapies. To date, a variety of gene-delivery vectors have been created and utilized for gene delivery. In general, they can be categorized into viral- and non-viral vectors. Due to safety issues associated with viral vectors, non-viral vectors have recently attracted much more research focus. Of these non-viral vectors, polymeric vectors, which have been preferred due to their low immunogenicity, ease of production, controlled chemical composition and high chemical versatility, have constituted an ideal alternative to viral vectors. In particular, biodegradable polymers, which possess advantageous biocompatibility and biosafety, have been considered to have great potential in clinical applications. In this context, the aim of this review is to introduce the recent development and progress of biodegradable polymers for gene delivery applications, especially for their chemical structure design, gene delivery capacity and additional biological functions. Accordingly, we first define and categorize biodegradable polymers, followed by describing their corresponding degradation mechanisms. Various types of biodegradable polymers resulting from natural and synthetic polymers will be introduced and their applications in gene delivery will be examined. Finally, a future perspective regarding the development of biodegradable polymer vectors will be given.Keywords: gene therapy, gene delivery, non-viral vectors, polymeric vectors, biodegradable polymers
format	article
author	Chen CK Huang PK Law WC Chu CH Chen NT Lo LW
author_facet	Chen CK Huang PK Law WC Chu CH Chen NT Lo LW
author_sort	Chen CK
title	Biodegradable Polymers for Gene-Delivery Applications
title_short	Biodegradable Polymers for Gene-Delivery Applications
title_full	Biodegradable Polymers for Gene-Delivery Applications
title_fullStr	Biodegradable Polymers for Gene-Delivery Applications
title_full_unstemmed	Biodegradable Polymers for Gene-Delivery Applications
title_sort	biodegradable polymers for gene-delivery applications
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/85ca5c11959d4028a0dad9e6b339cc55
work_keys_str_mv	AT chenck biodegradablepolymersforgenedeliveryapplications AT huangpk biodegradablepolymersforgenedeliveryapplications AT lawwc biodegradablepolymersforgenedeliveryapplications AT chuch biodegradablepolymersforgenedeliveryapplications AT chennt biodegradablepolymersforgenedeliveryapplications AT lolw biodegradablepolymersforgenedeliveryapplications
_version_	1718398074606321664

Biodegradable Polymers for Gene-Delivery Applications

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