Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy

Autosomal dominant optic atrophy is caused by mutations in the mitochondrial fusion protein OPA1. Here, the authors show that AMPK-induced autophagy depletes mitochondria in axons of retinal ganglion cells and that autophagic inhibition reverses vision loss in a mouse model.

Guardado en:

Detalles Bibliográficos
Autores principales:	Marta Zaninello, Konstantinos Palikaras, Deborah Naon, Keiko Iwata, Stephanie Herkenne, Ruben Quintana-Cabrera, Martina Semenzato, Francesca Grespi, Fred N. Ross-Cisneros, Valerio Carelli, Alfredo A. Sadun, Nektarios Tavernarakis, Luca Scorrano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85cc1dcbdee340b78b661df3a14cc334
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:85cc1dcbdee340b78b661df3a14cc334
record_format	dspace
spelling	oai:doaj.org-article:85cc1dcbdee340b78b661df3a14cc3342021-12-02T15:08:41ZInhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy10.1038/s41467-020-17821-12041-1723https://doaj.org/article/85cc1dcbdee340b78b661df3a14cc3342020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17821-1https://doaj.org/toc/2041-1723Autosomal dominant optic atrophy is caused by mutations in the mitochondrial fusion protein OPA1. Here, the authors show that AMPK-induced autophagy depletes mitochondria in axons of retinal ganglion cells and that autophagic inhibition reverses vision loss in a mouse model.Marta ZaninelloKonstantinos PalikarasDeborah NaonKeiko IwataStephanie HerkenneRuben Quintana-CabreraMartina SemenzatoFrancesca GrespiFred N. Ross-CisnerosValerio CarelliAlfredo A. SadunNektarios TavernarakisLuca ScorranoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marta Zaninello Konstantinos Palikaras Deborah Naon Keiko Iwata Stephanie Herkenne Ruben Quintana-Cabrera Martina Semenzato Francesca Grespi Fred N. Ross-Cisneros Valerio Carelli Alfredo A. Sadun Nektarios Tavernarakis Luca Scorrano Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy
description	Autosomal dominant optic atrophy is caused by mutations in the mitochondrial fusion protein OPA1. Here, the authors show that AMPK-induced autophagy depletes mitochondria in axons of retinal ganglion cells and that autophagic inhibition reverses vision loss in a mouse model.
format	article
author	Marta Zaninello Konstantinos Palikaras Deborah Naon Keiko Iwata Stephanie Herkenne Ruben Quintana-Cabrera Martina Semenzato Francesca Grespi Fred N. Ross-Cisneros Valerio Carelli Alfredo A. Sadun Nektarios Tavernarakis Luca Scorrano
author_facet	Marta Zaninello Konstantinos Palikaras Deborah Naon Keiko Iwata Stephanie Herkenne Ruben Quintana-Cabrera Martina Semenzato Francesca Grespi Fred N. Ross-Cisneros Valerio Carelli Alfredo A. Sadun Nektarios Tavernarakis Luca Scorrano
author_sort	Marta Zaninello
title	Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy
title_short	Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy
title_full	Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy
title_fullStr	Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy
title_full_unstemmed	Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy
title_sort	inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/85cc1dcbdee340b78b661df3a14cc334
work_keys_str_mv	AT martazaninello inhibitionofautophagycurtailsvisuallossinamodelofautosomaldominantopticatrophy AT konstantinospalikaras inhibitionofautophagycurtailsvisuallossinamodelofautosomaldominantopticatrophy AT deborahnaon inhibitionofautophagycurtailsvisuallossinamodelofautosomaldominantopticatrophy AT keikoiwata inhibitionofautophagycurtailsvisuallossinamodelofautosomaldominantopticatrophy AT stephanieherkenne inhibitionofautophagycurtailsvisuallossinamodelofautosomaldominantopticatrophy AT rubenquintanacabrera inhibitionofautophagycurtailsvisuallossinamodelofautosomaldominantopticatrophy AT martinasemenzato inhibitionofautophagycurtailsvisuallossinamodelofautosomaldominantopticatrophy AT francescagrespi inhibitionofautophagycurtailsvisuallossinamodelofautosomaldominantopticatrophy AT frednrosscisneros inhibitionofautophagycurtailsvisuallossinamodelofautosomaldominantopticatrophy AT valeriocarelli inhibitionofautophagycurtailsvisuallossinamodelofautosomaldominantopticatrophy AT alfredoasadun inhibitionofautophagycurtailsvisuallossinamodelofautosomaldominantopticatrophy AT nektariostavernarakis inhibitionofautophagycurtailsvisuallossinamodelofautosomaldominantopticatrophy AT lucascorrano inhibitionofautophagycurtailsvisuallossinamodelofautosomaldominantopticatrophy
_version_	1718388070442598400

Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy

Ejemplares similares