Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy

Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy

Autosomal dominant optic atrophy is caused by mutations in the mitochondrial fusion protein OPA1. Here, the authors show that AMPK-induced autophagy depletes mitochondria in axons of retinal ganglion cells and that autophagic inhibition reverses vision loss in a mouse model.

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Detalles Bibliográficos
Autores principales: Marta Zaninello, Konstantinos Palikaras, Deborah Naon, Keiko Iwata, Stephanie Herkenne, Ruben Quintana-Cabrera, Martina Semenzato, Francesca Grespi, Fred N. Ross-Cisneros, Valerio Carelli, Alfredo A. Sadun, Nektarios Tavernarakis, Luca Scorrano
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/85cc1dcbdee340b78b661df3a14cc334
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https://doaj.org/article/85cc1dcbdee340b78b661df3a14cc334

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