Structure and lipid dynamics in the maintenance of lipid asymmetry inner membrane complex of A. baumannii

Daniel Mann et al. describe a higher-resolution structure of the maintenance of lipid asymmetry inner membrane complex (MlaBDEF) in the Gram-negative pathogen, Acinetobacter baumannii. With this improved structural map, the authors clarify the secondary structure elements of MlaE helices and report...

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Autores principales:	Daniel Mann, Junping Fan, Kamolrat Somboon, Daniel P. Farrell, Andrew Muenks, Svetomir B. Tzokov, Frank DiMaio, Syma Khalid, Samuel I. Miller, Julien R. C. Bergeron
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/85d066ee80af486582adf7e304e0d791
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spelling	oai:doaj.org-article:85d066ee80af486582adf7e304e0d7912021-12-02T16:32:07ZStructure and lipid dynamics in the maintenance of lipid asymmetry inner membrane complex of A. baumannii10.1038/s42003-021-02318-42399-3642https://doaj.org/article/85d066ee80af486582adf7e304e0d7912021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02318-4https://doaj.org/toc/2399-3642Daniel Mann et al. describe a higher-resolution structure of the maintenance of lipid asymmetry inner membrane complex (MlaBDEF) in the Gram-negative pathogen, Acinetobacter baumannii. With this improved structural map, the authors clarify the secondary structure elements of MlaE helices and report on potential lipid dynamics by the MLA system that could inform the development of future therapeutics against A. baumannii infection.Daniel MannJunping FanKamolrat SomboonDaniel P. FarrellAndrew MuenksSvetomir B. TzokovFrank DiMaioSyma KhalidSamuel I. MillerJulien R. C. BergeronNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Daniel Mann Junping Fan Kamolrat Somboon Daniel P. Farrell Andrew Muenks Svetomir B. Tzokov Frank DiMaio Syma Khalid Samuel I. Miller Julien R. C. Bergeron Structure and lipid dynamics in the maintenance of lipid asymmetry inner membrane complex of A. baumannii
description	Daniel Mann et al. describe a higher-resolution structure of the maintenance of lipid asymmetry inner membrane complex (MlaBDEF) in the Gram-negative pathogen, Acinetobacter baumannii. With this improved structural map, the authors clarify the secondary structure elements of MlaE helices and report on potential lipid dynamics by the MLA system that could inform the development of future therapeutics against A. baumannii infection.
format	article
author	Daniel Mann Junping Fan Kamolrat Somboon Daniel P. Farrell Andrew Muenks Svetomir B. Tzokov Frank DiMaio Syma Khalid Samuel I. Miller Julien R. C. Bergeron
author_facet	Daniel Mann Junping Fan Kamolrat Somboon Daniel P. Farrell Andrew Muenks Svetomir B. Tzokov Frank DiMaio Syma Khalid Samuel I. Miller Julien R. C. Bergeron
author_sort	Daniel Mann
title	Structure and lipid dynamics in the maintenance of lipid asymmetry inner membrane complex of A. baumannii
title_short	Structure and lipid dynamics in the maintenance of lipid asymmetry inner membrane complex of A. baumannii
title_full	Structure and lipid dynamics in the maintenance of lipid asymmetry inner membrane complex of A. baumannii
title_fullStr	Structure and lipid dynamics in the maintenance of lipid asymmetry inner membrane complex of A. baumannii
title_full_unstemmed	Structure and lipid dynamics in the maintenance of lipid asymmetry inner membrane complex of A. baumannii
title_sort	structure and lipid dynamics in the maintenance of lipid asymmetry inner membrane complex of a. baumannii
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/85d066ee80af486582adf7e304e0d791
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Structure and lipid dynamics in the maintenance of lipid asymmetry inner membrane complex of A. baumannii

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