A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome

Jehn-Yu Huang, Po-Ting Yeh, Yu-Chih Hou Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan Purpose: To evaluate the efficacy of oral antioxidant supplementation in the treatment of patients with dry eye syndrome (DES)....

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Autores principales:	Huang JY, Yeh PT, Hou YC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	dry eye syndrome antioxidant reactive oxygen species herbal extracts Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/85d628f1987a4b299d74124b2969559f
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spelling	oai:doaj.org-article:85d628f1987a4b299d74124b2969559f2021-12-02T03:26:18ZA randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome1177-5483https://doaj.org/article/85d628f1987a4b299d74124b2969559f2016-05-01T00:00:00Zhttps://www.dovepress.com/a-randomized-double-blind-placebo-controlled-study-of-oral-antioxidant-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Jehn-Yu Huang, Po-Ting Yeh, Yu-Chih Hou Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan Purpose: To evaluate the efficacy of oral antioxidant supplementation in the treatment of patients with dry eye syndrome (DES). Methods: A prospective, randomized, double-blinded study compared the effects of an antioxidant supplement (containing anthocyanosides, astaxanthin, vitamins A, C, and E, and several herbal extracts, including Cassiae semen and Ophiopogonis japonicus) with placebo on patients with DES. We assessed dry eye symptoms, visual acuity, Schirmer’s test, tear film breakup time, cornea and conjunctiva fluorescein staining, serum anti-SSA/anti-SSB antibodies, and the level of reactive oxygen species (ROS) in tears. The supplementation period was 8 weeks and patients were followed up every 4 weeks for 16 weeks. A linear mixed model was used to compare the groups, while within-group differences were tested by repeated-measures analysis of variance. Results: Forty-three patients, 20 and 23 in treatment and placebo groups, respectively, completed the study. Liver and renal functions were normal. Diastolic blood pressure decreased in the treatment group. There were no significant differences in systolic blood pressure, dry eye symptoms, serum anti-SSA and anti-SSB, visual acuity, intraocular pressure, or fluorescein corneal staining between the groups. Tear film breakup time scores and Schirmer’s test without topical anesthesia significantly improved in the treatment group. Tear ROS level differed between the groups and decreased after treatment. Overall subjective impression revealed a significant improvement with treatment compared with placebo. Conclusion: Oral antioxidant supplementations may increase tear production and improve tear film stability by reducing tear ROS. The vegetable-based antioxidant supplement used in this study is safe and can be utilized as an adjuvant therapy to conventional artificial tear therapy for patients with DES. Keywords: dry eye, tear, reactive oxygen species, blood pressure, herbal extractsHuang JYYeh PTHou YCDove Medical Pressarticledry eye syndromeantioxidantreactive oxygen speciesherbal extractsOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 813-820 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	dry eye syndrome antioxidant reactive oxygen species herbal extracts Ophthalmology RE1-994
spellingShingle	dry eye syndrome antioxidant reactive oxygen species herbal extracts Ophthalmology RE1-994 Huang JY Yeh PT Hou YC A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome
description	Jehn-Yu Huang, Po-Ting Yeh, Yu-Chih Hou Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan Purpose: To evaluate the efficacy of oral antioxidant supplementation in the treatment of patients with dry eye syndrome (DES). Methods: A prospective, randomized, double-blinded study compared the effects of an antioxidant supplement (containing anthocyanosides, astaxanthin, vitamins A, C, and E, and several herbal extracts, including Cassiae semen and Ophiopogonis japonicus) with placebo on patients with DES. We assessed dry eye symptoms, visual acuity, Schirmer’s test, tear film breakup time, cornea and conjunctiva fluorescein staining, serum anti-SSA/anti-SSB antibodies, and the level of reactive oxygen species (ROS) in tears. The supplementation period was 8 weeks and patients were followed up every 4 weeks for 16 weeks. A linear mixed model was used to compare the groups, while within-group differences were tested by repeated-measures analysis of variance. Results: Forty-three patients, 20 and 23 in treatment and placebo groups, respectively, completed the study. Liver and renal functions were normal. Diastolic blood pressure decreased in the treatment group. There were no significant differences in systolic blood pressure, dry eye symptoms, serum anti-SSA and anti-SSB, visual acuity, intraocular pressure, or fluorescein corneal staining between the groups. Tear film breakup time scores and Schirmer’s test without topical anesthesia significantly improved in the treatment group. Tear ROS level differed between the groups and decreased after treatment. Overall subjective impression revealed a significant improvement with treatment compared with placebo. Conclusion: Oral antioxidant supplementations may increase tear production and improve tear film stability by reducing tear ROS. The vegetable-based antioxidant supplement used in this study is safe and can be utilized as an adjuvant therapy to conventional artificial tear therapy for patients with DES. Keywords: dry eye, tear, reactive oxygen species, blood pressure, herbal extracts
format	article
author	Huang JY Yeh PT Hou YC
author_facet	Huang JY Yeh PT Hou YC
author_sort	Huang JY
title	A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome
title_short	A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome
title_full	A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome
title_fullStr	A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome
title_full_unstemmed	A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome
title_sort	randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/85d628f1987a4b299d74124b2969559f
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A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome

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