Towards Picogram Detection of Superparamagnetic Iron-Oxide Particles Using a Gradiometric Receive Coil

Abstract Superparamagnetic iron-oxide nanoparticles can be used in medical applications like vascular or targeted imaging. Magnetic particle imaging (MPI) is a promising tomographic imaging technique that allows visualizing the 3D nanoparticle distribution concentration in a non-invasive manner. The...

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Autores principales:	Matthias Graeser, Tobias Knopp, Patryk Szwargulski, Thomas Friedrich, Anselm von Gladiss, Michael Kaul, Kannan M Krishnan, Harald Ittrich, Gerhard Adam, Thorsten M. Buzug
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/85d7ea6ccc7e4879acfb9b3bdcd61c0b
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spelling	oai:doaj.org-article:85d7ea6ccc7e4879acfb9b3bdcd61c0b2021-12-02T12:32:43ZTowards Picogram Detection of Superparamagnetic Iron-Oxide Particles Using a Gradiometric Receive Coil10.1038/s41598-017-06992-52045-2322https://doaj.org/article/85d7ea6ccc7e4879acfb9b3bdcd61c0b2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06992-5https://doaj.org/toc/2045-2322Abstract Superparamagnetic iron-oxide nanoparticles can be used in medical applications like vascular or targeted imaging. Magnetic particle imaging (MPI) is a promising tomographic imaging technique that allows visualizing the 3D nanoparticle distribution concentration in a non-invasive manner. The two main strengths of MPI are high temporal resolution and high sensitivity. While the first has been proven in the assessment of dynamic processes like cardiac imaging, it is unknown how far the detection limit of MPI can be lowered. Within this work, we will present a highly sensitive gradiometric receive-coil unit combined with a noise-matching network tailored for the imaging of mice. The setup is capable of detecting 5 ng of iron in-vitro with an acquisition time of 2.14 sec. In terms of iron concentration we are able to detect 156 μg/L marking the lowest value that has been reported for an MPI scanner so far. In-vivo MPI mouse images of a 512 ng bolus and a 21.5 ms acquisition time allow for capturing the flow of an intravenously injected tracer through the heart of a mouse. Since it has been rather difficult to compare detection limits across MPI publications we propose guidelines to improve the comparability of future MPI studies.Matthias GraeserTobias KnoppPatryk SzwargulskiThomas FriedrichAnselm von GladissMichael KaulKannan M KrishnanHarald IttrichGerhard AdamThorsten M. BuzugNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthias Graeser Tobias Knopp Patryk Szwargulski Thomas Friedrich Anselm von Gladiss Michael Kaul Kannan M Krishnan Harald Ittrich Gerhard Adam Thorsten M. Buzug Towards Picogram Detection of Superparamagnetic Iron-Oxide Particles Using a Gradiometric Receive Coil
description	Abstract Superparamagnetic iron-oxide nanoparticles can be used in medical applications like vascular or targeted imaging. Magnetic particle imaging (MPI) is a promising tomographic imaging technique that allows visualizing the 3D nanoparticle distribution concentration in a non-invasive manner. The two main strengths of MPI are high temporal resolution and high sensitivity. While the first has been proven in the assessment of dynamic processes like cardiac imaging, it is unknown how far the detection limit of MPI can be lowered. Within this work, we will present a highly sensitive gradiometric receive-coil unit combined with a noise-matching network tailored for the imaging of mice. The setup is capable of detecting 5 ng of iron in-vitro with an acquisition time of 2.14 sec. In terms of iron concentration we are able to detect 156 μg/L marking the lowest value that has been reported for an MPI scanner so far. In-vivo MPI mouse images of a 512 ng bolus and a 21.5 ms acquisition time allow for capturing the flow of an intravenously injected tracer through the heart of a mouse. Since it has been rather difficult to compare detection limits across MPI publications we propose guidelines to improve the comparability of future MPI studies.
format	article
author	Matthias Graeser Tobias Knopp Patryk Szwargulski Thomas Friedrich Anselm von Gladiss Michael Kaul Kannan M Krishnan Harald Ittrich Gerhard Adam Thorsten M. Buzug
author_facet	Matthias Graeser Tobias Knopp Patryk Szwargulski Thomas Friedrich Anselm von Gladiss Michael Kaul Kannan M Krishnan Harald Ittrich Gerhard Adam Thorsten M. Buzug
author_sort	Matthias Graeser
title	Towards Picogram Detection of Superparamagnetic Iron-Oxide Particles Using a Gradiometric Receive Coil
title_short	Towards Picogram Detection of Superparamagnetic Iron-Oxide Particles Using a Gradiometric Receive Coil
title_full	Towards Picogram Detection of Superparamagnetic Iron-Oxide Particles Using a Gradiometric Receive Coil
title_fullStr	Towards Picogram Detection of Superparamagnetic Iron-Oxide Particles Using a Gradiometric Receive Coil
title_full_unstemmed	Towards Picogram Detection of Superparamagnetic Iron-Oxide Particles Using a Gradiometric Receive Coil
title_sort	towards picogram detection of superparamagnetic iron-oxide particles using a gradiometric receive coil
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/85d7ea6ccc7e4879acfb9b3bdcd61c0b
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Towards Picogram Detection of Superparamagnetic Iron-Oxide Particles Using a Gradiometric Receive Coil

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