Cancer spectrum in TP53-deficient golden Syrian hamsters: A new model for li-fraumeni syndrome

Cancer spectrum in TP53-deficient golden Syrian hamsters: A new model for li-fraumeni syndrome

Background: The TP53 tumor suppressor gene is the most commonly mutated gene in human cancers. Humans who inherit mutant TP53 alleles develop a wide range of early onset cancers, a disorder called Li-Fraumeni Syndrome (LFS). Trp53-deficient mice recapitulate most but not all of the cancer phenotypes...

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Bibliographic Details
Main Authors: Jinxin Miao, Rong Li, Arnaud J Van Wettere, Haoran Guo, Alexandru-Flaviu Tabaran, M Gerald O'Sullivan, Timothy Carlson, Patricia M Scott, Kuisheng Chen, Dongling Gao, Huixiang Li, Yaohe Wang, Zhongde Wang, Robert T Cormier
Format: article
Language:EN
Published: Wolters Kluwer Medknow Publications 2021
Subjects:
cancer
hamsters
tp53
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/85da8c116d8c450bb20e5263e01c9ebc
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https://doaj.org/article/85da8c116d8c450bb20e5263e01c9ebc

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