The effect of topical ocular moxifloxacin on conjunctival and nasal mucosal flora

Abstract To determine the short-term effect of topically administered ocular moxifloxacin on conjunctival and nasal bacterial mucosal flora. The study included 20 patients with newly diagnosed age-related macular degeneration. Each patient’s diseased eye was selected as the treatment eye and the fel...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ali Riza Cenk Celebi, Ozlem Onerci Celebi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/85dbb54f698c4eae8d2d7083a390994d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:85dbb54f698c4eae8d2d7083a390994d
record_format	dspace
spelling	oai:doaj.org-article:85dbb54f698c4eae8d2d7083a390994d2021-12-02T18:18:51ZThe effect of topical ocular moxifloxacin on conjunctival and nasal mucosal flora10.1038/s41598-021-93233-52045-2322https://doaj.org/article/85dbb54f698c4eae8d2d7083a390994d2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93233-5https://doaj.org/toc/2045-2322Abstract To determine the short-term effect of topically administered ocular moxifloxacin on conjunctival and nasal bacterial mucosal flora. The study included 20 patients with newly diagnosed age-related macular degeneration. Each patient’s diseased eye was selected as the treatment eye and the fellow eye was selected as the control eye. All treatment eyes constituted the treatment group and all controls eyes constituted the control group. All patients received intravitreal injection of ranibizumab. Cultures were obtained from the inferior conjunctival fornix and the nostrils in all patients. Patients were instructed to administer moxifloxacin eye drops to the treatment eye 4 times daily for 1 week. The patients were instructed to come for a follow-up exam 1 week post intravitreal injection. The bacterial culture positivity rate and the bacteria isolated from the conjunctiva and nostrils were recorded in the 2 groups before and after use of topical ocular moxifloxacin. Mean age of the patients (12 female and 8 male) was 64.9 years. Before use of topical ocular moxifloxacin the conjunctival and nasal culture positivity rates in the treatment group were both 100%, versus 90% and 95%, respectively, in the control group. At the follow-up exam the conjunctival and nasal mucosa culture positivity rates in the treatment group decreased to 20% (4/20) and 30% (6/20), respectively (P < 0.001), versus 85% (17/20) and 80% (16/20), respectively, in the control group (P = 0.68 and P = 0.72 for conjunctival and nasal). This is the first study to show that moxifloxacin applied to the ocular surface topically has a significant effect on nasal flora. Daily administration of topical ocular moxifloxacin for 1 week significantly reduces the nasal bacterial flora in addition to conjunctival flora.Ali Riza Cenk CelebiOzlem Onerci CelebiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ali Riza Cenk Celebi Ozlem Onerci Celebi The effect of topical ocular moxifloxacin on conjunctival and nasal mucosal flora
description	Abstract To determine the short-term effect of topically administered ocular moxifloxacin on conjunctival and nasal bacterial mucosal flora. The study included 20 patients with newly diagnosed age-related macular degeneration. Each patient’s diseased eye was selected as the treatment eye and the fellow eye was selected as the control eye. All treatment eyes constituted the treatment group and all controls eyes constituted the control group. All patients received intravitreal injection of ranibizumab. Cultures were obtained from the inferior conjunctival fornix and the nostrils in all patients. Patients were instructed to administer moxifloxacin eye drops to the treatment eye 4 times daily for 1 week. The patients were instructed to come for a follow-up exam 1 week post intravitreal injection. The bacterial culture positivity rate and the bacteria isolated from the conjunctiva and nostrils were recorded in the 2 groups before and after use of topical ocular moxifloxacin. Mean age of the patients (12 female and 8 male) was 64.9 years. Before use of topical ocular moxifloxacin the conjunctival and nasal culture positivity rates in the treatment group were both 100%, versus 90% and 95%, respectively, in the control group. At the follow-up exam the conjunctival and nasal mucosa culture positivity rates in the treatment group decreased to 20% (4/20) and 30% (6/20), respectively (P < 0.001), versus 85% (17/20) and 80% (16/20), respectively, in the control group (P = 0.68 and P = 0.72 for conjunctival and nasal). This is the first study to show that moxifloxacin applied to the ocular surface topically has a significant effect on nasal flora. Daily administration of topical ocular moxifloxacin for 1 week significantly reduces the nasal bacterial flora in addition to conjunctival flora.
format	article
author	Ali Riza Cenk Celebi Ozlem Onerci Celebi
author_facet	Ali Riza Cenk Celebi Ozlem Onerci Celebi
author_sort	Ali Riza Cenk Celebi
title	The effect of topical ocular moxifloxacin on conjunctival and nasal mucosal flora
title_short	The effect of topical ocular moxifloxacin on conjunctival and nasal mucosal flora
title_full	The effect of topical ocular moxifloxacin on conjunctival and nasal mucosal flora
title_fullStr	The effect of topical ocular moxifloxacin on conjunctival and nasal mucosal flora
title_full_unstemmed	The effect of topical ocular moxifloxacin on conjunctival and nasal mucosal flora
title_sort	effect of topical ocular moxifloxacin on conjunctival and nasal mucosal flora
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/85dbb54f698c4eae8d2d7083a390994d
work_keys_str_mv	AT alirizacenkcelebi theeffectoftopicalocularmoxifloxacinonconjunctivalandnasalmucosalflora AT ozlemonercicelebi theeffectoftopicalocularmoxifloxacinonconjunctivalandnasalmucosalflora AT alirizacenkcelebi effectoftopicalocularmoxifloxacinonconjunctivalandnasalmucosalflora AT ozlemonercicelebi effectoftopicalocularmoxifloxacinonconjunctivalandnasalmucosalflora
_version_	1718378166298345472

The effect of topical ocular moxifloxacin on conjunctival and nasal mucosal flora

Ejemplares similares