TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis

TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis

The mechanisms underlying immunpathologies in dengue virus (DENV) infection are incompletely understood. Here, authors show that TLR2 recognizes DENV particles inducing cytokine expression and activating vascular endothelium cells in vitro, and that TLR2 expression on monocytes correlates with disea...

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Autores principales: José A. Aguilar-Briseño, Vinit Upasani, Bram M. ter Ellen, Jill Moser, Mindaugas Pauzuolis, Mariana Ruiz-Silva, Sothy Heng, Denis Laurent, Rithy Choeung, Philippe Dussart, Tineke Cantaert, Jolanda M. Smit, Izabela A. Rodenhuis-Zybert
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/85dea333a8ac4394b33be3faacbbdbda
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Sumario:The mechanisms underlying immunpathologies in dengue virus (DENV) infection are incompletely understood. Here, authors show that TLR2 recognizes DENV particles inducing cytokine expression and activating vascular endothelium cells in vitro, and that TLR2 expression on monocytes correlates with disease severity in patients.

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