TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis

The mechanisms underlying immunpathologies in dengue virus (DENV) infection are incompletely understood. Here, authors show that TLR2 recognizes DENV particles inducing cytokine expression and activating vascular endothelium cells in vitro, and that TLR2 expression on monocytes correlates with disea...

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Autores principales:	José A. Aguilar-Briseño, Vinit Upasani, Bram M. ter Ellen, Jill Moser, Mindaugas Pauzuolis, Mariana Ruiz-Silva, Sothy Heng, Denis Laurent, Rithy Choeung, Philippe Dussart, Tineke Cantaert, Jolanda M. Smit, Izabela A. Rodenhuis-Zybert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85dea333a8ac4394b33be3faacbbdbda
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spelling	oai:doaj.org-article:85dea333a8ac4394b33be3faacbbdbda2021-12-02T18:02:42ZTLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis10.1038/s41467-020-16849-72041-1723https://doaj.org/article/85dea333a8ac4394b33be3faacbbdbda2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16849-7https://doaj.org/toc/2041-1723The mechanisms underlying immunpathologies in dengue virus (DENV) infection are incompletely understood. Here, authors show that TLR2 recognizes DENV particles inducing cytokine expression and activating vascular endothelium cells in vitro, and that TLR2 expression on monocytes correlates with disease severity in patients.José A. Aguilar-BriseñoVinit UpasaniBram M. ter EllenJill MoserMindaugas PauzuolisMariana Ruiz-SilvaSothy HengDenis LaurentRithy ChoeungPhilippe DussartTineke CantaertJolanda M. SmitIzabela A. Rodenhuis-ZybertNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q José A. Aguilar-Briseño Vinit Upasani Bram M. ter Ellen Jill Moser Mindaugas Pauzuolis Mariana Ruiz-Silva Sothy Heng Denis Laurent Rithy Choeung Philippe Dussart Tineke Cantaert Jolanda M. Smit Izabela A. Rodenhuis-Zybert TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis
description	The mechanisms underlying immunpathologies in dengue virus (DENV) infection are incompletely understood. Here, authors show that TLR2 recognizes DENV particles inducing cytokine expression and activating vascular endothelium cells in vitro, and that TLR2 expression on monocytes correlates with disease severity in patients.
format	article
author	José A. Aguilar-Briseño Vinit Upasani Bram M. ter Ellen Jill Moser Mindaugas Pauzuolis Mariana Ruiz-Silva Sothy Heng Denis Laurent Rithy Choeung Philippe Dussart Tineke Cantaert Jolanda M. Smit Izabela A. Rodenhuis-Zybert
author_facet	José A. Aguilar-Briseño Vinit Upasani Bram M. ter Ellen Jill Moser Mindaugas Pauzuolis Mariana Ruiz-Silva Sothy Heng Denis Laurent Rithy Choeung Philippe Dussart Tineke Cantaert Jolanda M. Smit Izabela A. Rodenhuis-Zybert
author_sort	José A. Aguilar-Briseño
title	TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis
title_short	TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis
title_full	TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis
title_fullStr	TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis
title_full_unstemmed	TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis
title_sort	tlr2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/85dea333a8ac4394b33be3faacbbdbda
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TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis

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