Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma

Head and neck squamous cell carcinomas (HNSCC) often harbourPIK3CAmutations but PI3Kα inhibitors can cause some side effects. Here, the authors develop P-selectin targeted nanoparticles to enhance tumour-specific delivery of a PI3Kα inhibitor to HNSCC PDX and orthotopic xenograft models.

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Autores principales:	Aviram Mizrachi, Yosi Shamay, Janki Shah, Samuel Brook, Joanne Soong, Vinagolu K. Rajasekhar, John L. Humm, John H. Healey, Simon N. Powell, José Baselga, Daniel A. Heller, Adriana Haimovitz-Friedman, Maurizio Scaltriti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85df8a21d4544f45aef7b25946bd4c53
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spelling	oai:doaj.org-article:85df8a21d4544f45aef7b25946bd4c532021-12-02T14:42:40ZTumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma10.1038/ncomms142922041-1723https://doaj.org/article/85df8a21d4544f45aef7b25946bd4c532017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14292https://doaj.org/toc/2041-1723Head and neck squamous cell carcinomas (HNSCC) often harbourPIK3CAmutations but PI3Kα inhibitors can cause some side effects. Here, the authors develop P-selectin targeted nanoparticles to enhance tumour-specific delivery of a PI3Kα inhibitor to HNSCC PDX and orthotopic xenograft models.Aviram MizrachiYosi ShamayJanki ShahSamuel BrookJoanne SoongVinagolu K. RajasekharJohn L. HummJohn H. HealeySimon N. PowellJosé BaselgaDaniel A. HellerAdriana Haimovitz-FriedmanMaurizio ScaltritiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aviram Mizrachi Yosi Shamay Janki Shah Samuel Brook Joanne Soong Vinagolu K. Rajasekhar John L. Humm John H. Healey Simon N. Powell José Baselga Daniel A. Heller Adriana Haimovitz-Friedman Maurizio Scaltriti Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma
description	Head and neck squamous cell carcinomas (HNSCC) often harbourPIK3CAmutations but PI3Kα inhibitors can cause some side effects. Here, the authors develop P-selectin targeted nanoparticles to enhance tumour-specific delivery of a PI3Kα inhibitor to HNSCC PDX and orthotopic xenograft models.
format	article
author	Aviram Mizrachi Yosi Shamay Janki Shah Samuel Brook Joanne Soong Vinagolu K. Rajasekhar John L. Humm John H. Healey Simon N. Powell José Baselga Daniel A. Heller Adriana Haimovitz-Friedman Maurizio Scaltriti
author_facet	Aviram Mizrachi Yosi Shamay Janki Shah Samuel Brook Joanne Soong Vinagolu K. Rajasekhar John L. Humm John H. Healey Simon N. Powell José Baselga Daniel A. Heller Adriana Haimovitz-Friedman Maurizio Scaltriti
author_sort	Aviram Mizrachi
title	Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma
title_short	Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma
title_full	Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma
title_fullStr	Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma
title_full_unstemmed	Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma
title_sort	tumour-specific pi3k inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/85df8a21d4544f45aef7b25946bd4c53
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Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma

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