Estimating the burden and modeling mitigation strategies of pork-related hepatitis E virus foodborne transmission in representative European countries

Hepatitis E virus (HEV) is an emerging zoonotic pathogen posing global health burden, and the concerns in Europe are tremendously growing. Pigs serve as a main reservoir, contributing to pork-related foodborne transmission. In this study, we aim to specifically simulate this foodborne transmission r...

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Autores principales:	Yunpeng Ji, Pengfei Li, Yueqi Jia, Xiaohua Wang, Qinyue Zheng, Maikel P. Peppelenbosch, Zhongren Ma, Qiuwei Pan
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	HEV Foodborne transmission Vaccine Mathematical modeling Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/85dfc5aabadf424ab010481fb68112bf
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spelling	oai:doaj.org-article:85dfc5aabadf424ab010481fb68112bf2021-11-20T05:07:31ZEstimating the burden and modeling mitigation strategies of pork-related hepatitis E virus foodborne transmission in representative European countries2352-771410.1016/j.onehlt.2021.100350https://doaj.org/article/85dfc5aabadf424ab010481fb68112bf2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352771421001403https://doaj.org/toc/2352-7714Hepatitis E virus (HEV) is an emerging zoonotic pathogen posing global health burden, and the concerns in Europe are tremendously growing. Pigs serve as a main reservoir, contributing to pork-related foodborne transmission. In this study, we aim to specifically simulate this foodborne transmission route and to assess potential interventions. We firstly established a dose-response relationship between the risk of transmission to human and the amount of ingested viruses. We further estimated the incidence of HEV infection specifically attributed to pork-related foodborne transmission in four representative European countries. Finally, we demonstrated a proof-of-concept of mitigating HEV transmission by implementing vaccination in human and pig populations. Our modeling approach bears essential implications for better understanding the transmission of pork-related foodborne HEV and for developing mitigation strategies.Yunpeng JiPengfei LiYueqi JiaXiaohua WangQinyue ZhengMaikel P. PeppelenboschZhongren MaQiuwei PanElsevierarticleHEVFoodborne transmissionVaccineMathematical modelingMedicine (General)R5-920ENOne Health, Vol 13, Iss , Pp 100350- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HEV Foodborne transmission Vaccine Mathematical modeling Medicine (General) R5-920
spellingShingle	HEV Foodborne transmission Vaccine Mathematical modeling Medicine (General) R5-920 Yunpeng Ji Pengfei Li Yueqi Jia Xiaohua Wang Qinyue Zheng Maikel P. Peppelenbosch Zhongren Ma Qiuwei Pan Estimating the burden and modeling mitigation strategies of pork-related hepatitis E virus foodborne transmission in representative European countries
description	Hepatitis E virus (HEV) is an emerging zoonotic pathogen posing global health burden, and the concerns in Europe are tremendously growing. Pigs serve as a main reservoir, contributing to pork-related foodborne transmission. In this study, we aim to specifically simulate this foodborne transmission route and to assess potential interventions. We firstly established a dose-response relationship between the risk of transmission to human and the amount of ingested viruses. We further estimated the incidence of HEV infection specifically attributed to pork-related foodborne transmission in four representative European countries. Finally, we demonstrated a proof-of-concept of mitigating HEV transmission by implementing vaccination in human and pig populations. Our modeling approach bears essential implications for better understanding the transmission of pork-related foodborne HEV and for developing mitigation strategies.
format	article
author	Yunpeng Ji Pengfei Li Yueqi Jia Xiaohua Wang Qinyue Zheng Maikel P. Peppelenbosch Zhongren Ma Qiuwei Pan
author_facet	Yunpeng Ji Pengfei Li Yueqi Jia Xiaohua Wang Qinyue Zheng Maikel P. Peppelenbosch Zhongren Ma Qiuwei Pan
author_sort	Yunpeng Ji
title	Estimating the burden and modeling mitigation strategies of pork-related hepatitis E virus foodborne transmission in representative European countries
title_short	Estimating the burden and modeling mitigation strategies of pork-related hepatitis E virus foodborne transmission in representative European countries
title_full	Estimating the burden and modeling mitigation strategies of pork-related hepatitis E virus foodborne transmission in representative European countries
title_fullStr	Estimating the burden and modeling mitigation strategies of pork-related hepatitis E virus foodborne transmission in representative European countries
title_full_unstemmed	Estimating the burden and modeling mitigation strategies of pork-related hepatitis E virus foodborne transmission in representative European countries
title_sort	estimating the burden and modeling mitigation strategies of pork-related hepatitis e virus foodborne transmission in representative european countries
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/85dfc5aabadf424ab010481fb68112bf
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Estimating the burden and modeling mitigation strategies of pork-related hepatitis E virus foodborne transmission in representative European countries

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