Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats

Dadong Han1, Yutao Tian2, Tao Zhang2, Guogang Ren3, Zhuo Yang11School of Medicine, The Key Laboratory of Bioactive Materials, Ministry of Education, 2College of Life Science, Nankai University, Tianjin, China; 3Science and Technology Research Institute, University of Hertfordshire, Hatfield, Hertfor...

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Autores principales:	Han D, Tian Y, Zhang T, Ren G, Yang Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/85e3228e34e2478aaa2ed97ccfaccac6
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spelling	oai:doaj.org-article:85e3228e34e2478aaa2ed97ccfaccac62021-12-02T01:58:49ZNano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats1176-91141178-2013https://doaj.org/article/85e3228e34e2478aaa2ed97ccfaccac62011-07-01T00:00:00Zhttp://www.dovepress.com/nano-zinc-oxide-damages-spatial-cognition-capability-via-over-enhanced-a7840https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Dadong Han1, Yutao Tian2, Tao Zhang2, Guogang Ren3, Zhuo Yang11School of Medicine, The Key Laboratory of Bioactive Materials, Ministry of Education, 2College of Life Science, Nankai University, Tianjin, China; 3Science and Technology Research Institute, University of Hertfordshire, Hatfield, Hertfordshire, UKAbstract: This study focused on the effects of zinc oxide nanoparticles (nano-ZnO) on spatial learning and memory and synaptic plasticity in the hippocampus of young rats, and tried to interpret the underlying mechanism. Rats were randomly divided into four groups. Nano-ZnO and phosphate-buffered saline were administered in 4-week-old rats for 8 weeks. Subsequently, performance in Morris water maze (MWM) was determined, and then long-term potentiation (LTP) and depotentiation were measured in the perforant pathway to dentate gyrus (DG) in anesthetized rats. The data showed that, (1) in MWM, the escape latency was prolonged in the nano-ZnO group and, (2) LTP was significantly enhanced in the nano-ZnO group, while depotentiation was barely influenced in the DG region of the nano-ZnO group. This bidirectional effect on long-term synaptic plasticity broke the balance between stability and flexibility of cognition. The spatial learning and memory ability was attenuated by the alteration of synaptic plasticity in nano-ZnO-treated rats.Keywords: zinc oxide nanoparticles, synaptic plasticity, long-term potentiation, depotentiation, spatial learning, memoryHan DTian YZhang TRen GYang ZDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1453-1461 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Han D Tian Y Zhang T Ren G Yang Z Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats
description	Dadong Han1, Yutao Tian2, Tao Zhang2, Guogang Ren3, Zhuo Yang11School of Medicine, The Key Laboratory of Bioactive Materials, Ministry of Education, 2College of Life Science, Nankai University, Tianjin, China; 3Science and Technology Research Institute, University of Hertfordshire, Hatfield, Hertfordshire, UKAbstract: This study focused on the effects of zinc oxide nanoparticles (nano-ZnO) on spatial learning and memory and synaptic plasticity in the hippocampus of young rats, and tried to interpret the underlying mechanism. Rats were randomly divided into four groups. Nano-ZnO and phosphate-buffered saline were administered in 4-week-old rats for 8 weeks. Subsequently, performance in Morris water maze (MWM) was determined, and then long-term potentiation (LTP) and depotentiation were measured in the perforant pathway to dentate gyrus (DG) in anesthetized rats. The data showed that, (1) in MWM, the escape latency was prolonged in the nano-ZnO group and, (2) LTP was significantly enhanced in the nano-ZnO group, while depotentiation was barely influenced in the DG region of the nano-ZnO group. This bidirectional effect on long-term synaptic plasticity broke the balance between stability and flexibility of cognition. The spatial learning and memory ability was attenuated by the alteration of synaptic plasticity in nano-ZnO-treated rats.Keywords: zinc oxide nanoparticles, synaptic plasticity, long-term potentiation, depotentiation, spatial learning, memory
format	article
author	Han D Tian Y Zhang T Ren G Yang Z
author_facet	Han D Tian Y Zhang T Ren G Yang Z
author_sort	Han D
title	Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats
title_short	Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats
title_full	Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats
title_fullStr	Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats
title_full_unstemmed	Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats
title_sort	nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of wistar rats
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/85e3228e34e2478aaa2ed97ccfaccac6
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Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats

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