Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations

V Mazzarello, MG Donadu, M Ferrari, G Piga, D Usai, S Zanetti, MA Sotgiu Skinlab, Department of Biomedical Sciences, University of Sassari, Sassari, Italy Introduction: Antibiotics that suppress Propionibacterium acnes are the standard treatment for acne but are becoming less effective, due to the a...

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Autores principales:	Mazzarello V, Donadu MG, Ferrari M, Piga G, Usai D, Zanetti S, Sotgiu MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Phytotherapy Aloe Barbadensis Malaluca alternifolia oil Propolis Non-invasive analysis Antibiotic resistance. Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/85e4544d9e8f4e289b4785b5d469ea89
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spelling	oai:doaj.org-article:85e4544d9e8f4e289b4785b5d469ea892021-12-02T07:59:44ZTreatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations1179-1438https://doaj.org/article/85e4544d9e8f4e289b4785b5d469ea892018-12-01T00:00:00Zhttps://www.dovepress.com/treatment-of-acne-with-a-combination-of-propolis-tea-tree-oil-and-aloe-peer-reviewed-article-CPAAhttps://doaj.org/toc/1179-1438V Mazzarello, MG Donadu, M Ferrari, G Piga, D Usai, S Zanetti, MA Sotgiu Skinlab, Department of Biomedical Sciences, University of Sassari, Sassari, Italy Introduction: Antibiotics that suppress Propionibacterium acnes are the standard treatment for acne but are becoming less effective, due to the appearance of antibiotic-resistant strains. Many plants are known to have innate antimicrobial action and can be used as alternatives to antibiotics; thus, it is necessary to prove their effectiveness in vivo. This study aimed to evaluate the anti-acne efficacy of a new cream based on three natural extracts, comparing it to erythromycin cream and placebo. Patients and methods: Sixty patients with mild to moderate acne vulgaris were randomly divided into three groups: treated with cream containing 20% propolis, 3% “tea tree oil”, and 10% “Aloe vera” (PTAC) (n=20); or with 3% erythromycin cream (ERC) (n=20); or with placebo (n=20). At baseline, after 15 and 30 days, investigators evaluated response to treatment by counting acne lesions through noninvasive measurements and macro-photography. Results: All the clinical and instrumental values studied were statistically different from placebo except for sebometry, pHmetry, and erythema index values, measured on healthy skin. Unlike in the placebo group, papular and scar lesions showed high erythema reduction after 15 and 30 days of PTAC and ERC application. Conclusion: The PTAC formulation was better than ERC in reducing erythema scars, acne severity index, and total lesion count. Keywords: phytotherapy, Aloe barbadensis, Melaleuca alternifolia oil, propolis, noninvasive analysis, antibiotic resistanceMazzarello VDonadu MGFerrari MPiga GUsai DZanetti SSotgiu MADove Medical PressarticlePhytotherapyAloe BarbadensisMalaluca alternifolia oilPropolisNon-invasive analysisAntibiotic resistance.Therapeutics. PharmacologyRM1-950ENClinical Pharmacology: Advances and Applications, Vol Volume 10, Pp 175-181 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Phytotherapy Aloe Barbadensis Malaluca alternifolia oil Propolis Non-invasive analysis Antibiotic resistance. Therapeutics. Pharmacology RM1-950
spellingShingle	Phytotherapy Aloe Barbadensis Malaluca alternifolia oil Propolis Non-invasive analysis Antibiotic resistance. Therapeutics. Pharmacology RM1-950 Mazzarello V Donadu MG Ferrari M Piga G Usai D Zanetti S Sotgiu MA Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
description	V Mazzarello, MG Donadu, M Ferrari, G Piga, D Usai, S Zanetti, MA Sotgiu Skinlab, Department of Biomedical Sciences, University of Sassari, Sassari, Italy Introduction: Antibiotics that suppress Propionibacterium acnes are the standard treatment for acne but are becoming less effective, due to the appearance of antibiotic-resistant strains. Many plants are known to have innate antimicrobial action and can be used as alternatives to antibiotics; thus, it is necessary to prove their effectiveness in vivo. This study aimed to evaluate the anti-acne efficacy of a new cream based on three natural extracts, comparing it to erythromycin cream and placebo. Patients and methods: Sixty patients with mild to moderate acne vulgaris were randomly divided into three groups: treated with cream containing 20% propolis, 3% “tea tree oil”, and 10% “Aloe vera” (PTAC) (n=20); or with 3% erythromycin cream (ERC) (n=20); or with placebo (n=20). At baseline, after 15 and 30 days, investigators evaluated response to treatment by counting acne lesions through noninvasive measurements and macro-photography. Results: All the clinical and instrumental values studied were statistically different from placebo except for sebometry, pHmetry, and erythema index values, measured on healthy skin. Unlike in the placebo group, papular and scar lesions showed high erythema reduction after 15 and 30 days of PTAC and ERC application. Conclusion: The PTAC formulation was better than ERC in reducing erythema scars, acne severity index, and total lesion count. Keywords: phytotherapy, Aloe barbadensis, Melaleuca alternifolia oil, propolis, noninvasive analysis, antibiotic resistance
format	article
author	Mazzarello V Donadu MG Ferrari M Piga G Usai D Zanetti S Sotgiu MA
author_facet	Mazzarello V Donadu MG Ferrari M Piga G Usai D Zanetti S Sotgiu MA
author_sort	Mazzarello V
title	Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
title_short	Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
title_full	Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
title_fullStr	Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
title_full_unstemmed	Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
title_sort	treatment of acne with a combination of propolis, tea tree oil, and aloe vera compared to erythromycin cream: two double-blind investigations
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/85e4544d9e8f4e289b4785b5d469ea89
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Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations

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