Gasdermin D deficiency attenuates arthritis induced by traumatic injury but not autoantibody-assembled immune complexes

Gasdermin D deficiency attenuates arthritis induced by traumatic injury but not autoantibody-assembled immune complexes

Abstract Background Gasdermin D (GSDMD) is cleaved by several proteases including by caspase-1, a component of intracellular protein complexes called inflammasomes. Caspase-1 also converts pro-interleukin-1β (pro-IL-1β) and pro-IL-18 into bioactive IL-1β and IL-18, respectively. GSDMD amino-terminal...

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Bibliographic Details
Main Authors: Tong Yang, Kai Sun, Chun Wang, Gaurav Swarnkar, Songtao Quan, Dustin Kress, Jianqiu Xiao, Yael Alippe, Hongjun Zheng, Robert H Brophy, Dingjun Hao, Audrey McAlinden, Yousef Abu-Amer, Jie Shen, Gabriel Mbalaviele
Format: article
Language:EN
Published: BMC 2021
Subjects:
GSDMD
IL-1
Inflammasome
Inflammation
Immune cells
Pyroptosis
Diseases of the musculoskeletal system
RC925-935
Online Access:https://doaj.org/article/85e85314d3ee434fb76113941a98d1d4
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