Genomic Determinants Encode the Reactivity and Regioselectivity of Flavin-Dependent Halogenases in Bacterial Genomes and Metagenomes
Halogenases are playing an important role as tailoring enzymes in biosynthetic pathways. Flavin-dependent tryptophan halogenases (Trp-FDHs) are among the enzymes that have broad substrate scope and high selectivity.
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American Society for Microbiology
2021
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oai:doaj.org-article:85eb866c48f147f1b42dc39cc799917b2021-12-02T15:16:36ZGenomic Determinants Encode the Reactivity and Regioselectivity of Flavin-Dependent Halogenases in Bacterial Genomes and Metagenomes2379-507710.1128/mSystems.00053-21https://doaj.org/article/85eb866c48f147f1b42dc39cc799917b2021-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00053-21https://doaj.org/toc/2379-5077 Halogenases are playing an important role as tailoring enzymes in biosynthetic pathways. Flavin-dependent tryptophan halogenases (Trp-FDHs) are among the enzymes that have broad substrate scope and high selectivity.Jehyun JeonJaehee LeeSe-Min JungJae Hong ShinWoon Ju SongMina RhoAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmSystems, Vol 6, Iss 3 (2021) |
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Microbiology QR1-502 |
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Microbiology QR1-502 Jehyun Jeon Jaehee Lee Se-Min Jung Jae Hong Shin Woon Ju Song Mina Rho Genomic Determinants Encode the Reactivity and Regioselectivity of Flavin-Dependent Halogenases in Bacterial Genomes and Metagenomes |
description |
Halogenases are playing an important role as tailoring enzymes in biosynthetic pathways. Flavin-dependent tryptophan halogenases (Trp-FDHs) are among the enzymes that have broad substrate scope and high selectivity. |
format |
article |
author |
Jehyun Jeon Jaehee Lee Se-Min Jung Jae Hong Shin Woon Ju Song Mina Rho |
author_facet |
Jehyun Jeon Jaehee Lee Se-Min Jung Jae Hong Shin Woon Ju Song Mina Rho |
author_sort |
Jehyun Jeon |
title |
Genomic Determinants Encode the Reactivity and Regioselectivity of Flavin-Dependent Halogenases in Bacterial Genomes and Metagenomes |
title_short |
Genomic Determinants Encode the Reactivity and Regioselectivity of Flavin-Dependent Halogenases in Bacterial Genomes and Metagenomes |
title_full |
Genomic Determinants Encode the Reactivity and Regioselectivity of Flavin-Dependent Halogenases in Bacterial Genomes and Metagenomes |
title_fullStr |
Genomic Determinants Encode the Reactivity and Regioselectivity of Flavin-Dependent Halogenases in Bacterial Genomes and Metagenomes |
title_full_unstemmed |
Genomic Determinants Encode the Reactivity and Regioselectivity of Flavin-Dependent Halogenases in Bacterial Genomes and Metagenomes |
title_sort |
genomic determinants encode the reactivity and regioselectivity of flavin-dependent halogenases in bacterial genomes and metagenomes |
publisher |
American Society for Microbiology |
publishDate |
2021 |
url |
https://doaj.org/article/85eb866c48f147f1b42dc39cc799917b |
work_keys_str_mv |
AT jehyunjeon genomicdeterminantsencodethereactivityandregioselectivityofflavindependenthalogenasesinbacterialgenomesandmetagenomes AT jaeheelee genomicdeterminantsencodethereactivityandregioselectivityofflavindependenthalogenasesinbacterialgenomesandmetagenomes AT seminjung genomicdeterminantsencodethereactivityandregioselectivityofflavindependenthalogenasesinbacterialgenomesandmetagenomes AT jaehongshin genomicdeterminantsencodethereactivityandregioselectivityofflavindependenthalogenasesinbacterialgenomesandmetagenomes AT woonjusong genomicdeterminantsencodethereactivityandregioselectivityofflavindependenthalogenasesinbacterialgenomesandmetagenomes AT minarho genomicdeterminantsencodethereactivityandregioselectivityofflavindependenthalogenasesinbacterialgenomesandmetagenomes |
_version_ |
1718387456982646784 |