Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development

The transcription factor Runx2 regulates osteoblast differentiation of mesenchymal stem cells. In this manuscript, the authors, using a specific conditional knock-out mouse model and molecular studies, demonstrate that the mediator subunit MED23 binds to Runx2 and is essential for driving mesenchyma...

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Autores principales:	Zhen Liu, Xiao Yao, Guang Yan, YiChi Xu, Jun Yan, Weiguo Zou, Gang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85f1a579621d41f9903c5d1471ad188e
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id	oai:doaj.org-article:85f1a579621d41f9903c5d1471ad188e
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spelling	oai:doaj.org-article:85f1a579621d41f9903c5d1471ad188e2021-12-02T16:49:57ZMediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development10.1038/ncomms111492041-1723https://doaj.org/article/85f1a579621d41f9903c5d1471ad188e2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11149https://doaj.org/toc/2041-1723The transcription factor Runx2 regulates osteoblast differentiation of mesenchymal stem cells. In this manuscript, the authors, using a specific conditional knock-out mouse model and molecular studies, demonstrate that the mediator subunit MED23 binds to Runx2 and is essential for driving mesenchymal stem cells toward an osteoblast fate.Zhen LiuXiao YaoGuang YanYiChi XuJun YanWeiguo ZouGang WangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhen Liu Xiao Yao Guang Yan YiChi Xu Jun Yan Weiguo Zou Gang Wang Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development
description	The transcription factor Runx2 regulates osteoblast differentiation of mesenchymal stem cells. In this manuscript, the authors, using a specific conditional knock-out mouse model and molecular studies, demonstrate that the mediator subunit MED23 binds to Runx2 and is essential for driving mesenchymal stem cells toward an osteoblast fate.
format	article
author	Zhen Liu Xiao Yao Guang Yan YiChi Xu Jun Yan Weiguo Zou Gang Wang
author_facet	Zhen Liu Xiao Yao Guang Yan YiChi Xu Jun Yan Weiguo Zou Gang Wang
author_sort	Zhen Liu
title	Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development
title_short	Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development
title_full	Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development
title_fullStr	Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development
title_full_unstemmed	Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development
title_sort	mediator med23 cooperates with runx2 to drive osteoblast differentiation and bone development
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/85f1a579621d41f9903c5d1471ad188e
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Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development

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