The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue

Objective: To compare the T-cadherin, E-cadherin, PR and ER staining levels of deep infiltrating endometriosis (DIE) tissue, ovarian endometriomas and normal endometrial tissues. Materials and methods: DIE tissue of 24 cases, endometrioma of 30 cases and normal endometrial tissues of 30 cases were e...

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Autores principales:	Ismail Biyik, Uzeyir Kalkan, Sercan Simsek
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	T-cadherin E-cadherin Progesterone receptor Oestrogen receptor Endometriosis Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/85f37972174b424da55c22c05590c1b1
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spelling	oai:doaj.org-article:85f37972174b424da55c22c05590c1b12021-11-18T04:44:44ZThe deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue1028-455910.1016/j.tjog.2021.09.017https://doaj.org/article/85f37972174b424da55c22c05590c1b12021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1028455921002576https://doaj.org/toc/1028-4559Objective: To compare the T-cadherin, E-cadherin, PR and ER staining levels of deep infiltrating endometriosis (DIE) tissue, ovarian endometriomas and normal endometrial tissues. Materials and methods: DIE tissue of 24 cases, endometrioma of 30 cases and normal endometrial tissues of 30 cases were examined. T-cadherin, E-cadherin, ER-α and PR-α staining levels of DIE, endometrioma tissues and endometrial tissues were compared immunohistochemically. H-score was calculated to compare the expression of T-cadherin, E-cadherin, ER-α, PR-α in IHC staining based on the percentage of cells stained at each intensity level. Results: T-cadherin, E-cadherin, ER and PR H-score were found lowest in DIE tissue and the highest in endometrial tissue (p < 0.0001, <0.0001, <0.0001 and < 0.0001, respectively). In correlation analysis, a positive correlation was found between T-cadherin, E-cadherin, PR and ER H-score (p < 0.0001 for each). No correlation was found between age, body mass index (BMI), visual analog scale (VAS) score, CA125, endometrioma size and the severity of dysmenorrhea, dyspareunia and dystonia (p > 0.05). Conclusion: T-cadherin, E-cadherin, ER and PR H-score were found lowest in DIE tissue, the highest in endometrium tissue. The finding of lower expression of PR-α in endometriotic nodule in our study may be related to decrease in progesterone effect which could not inhibit the decrease in the expression of T-cadherin and E-cadherin, thus the invasiveness of DIE tissue. These findings suggest that DIE tissue and ovarian endometrioma tissues have a different biology.Ismail BiyikUzeyir KalkanSercan SimsekElsevierarticleT-cadherinE-cadherinProgesterone receptorOestrogen receptorEndometriosisGynecology and obstetricsRG1-991ENTaiwanese Journal of Obstetrics & Gynecology, Vol 60, Iss 6, Pp 1059-1065 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	T-cadherin E-cadherin Progesterone receptor Oestrogen receptor Endometriosis Gynecology and obstetrics RG1-991
spellingShingle	T-cadherin E-cadherin Progesterone receptor Oestrogen receptor Endometriosis Gynecology and obstetrics RG1-991 Ismail Biyik Uzeyir Kalkan Sercan Simsek The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue
description	Objective: To compare the T-cadherin, E-cadherin, PR and ER staining levels of deep infiltrating endometriosis (DIE) tissue, ovarian endometriomas and normal endometrial tissues. Materials and methods: DIE tissue of 24 cases, endometrioma of 30 cases and normal endometrial tissues of 30 cases were examined. T-cadherin, E-cadherin, ER-α and PR-α staining levels of DIE, endometrioma tissues and endometrial tissues were compared immunohistochemically. H-score was calculated to compare the expression of T-cadherin, E-cadherin, ER-α, PR-α in IHC staining based on the percentage of cells stained at each intensity level. Results: T-cadherin, E-cadherin, ER and PR H-score were found lowest in DIE tissue and the highest in endometrial tissue (p < 0.0001, <0.0001, <0.0001 and < 0.0001, respectively). In correlation analysis, a positive correlation was found between T-cadherin, E-cadherin, PR and ER H-score (p < 0.0001 for each). No correlation was found between age, body mass index (BMI), visual analog scale (VAS) score, CA125, endometrioma size and the severity of dysmenorrhea, dyspareunia and dystonia (p > 0.05). Conclusion: T-cadherin, E-cadherin, ER and PR H-score were found lowest in DIE tissue, the highest in endometrium tissue. The finding of lower expression of PR-α in endometriotic nodule in our study may be related to decrease in progesterone effect which could not inhibit the decrease in the expression of T-cadherin and E-cadherin, thus the invasiveness of DIE tissue. These findings suggest that DIE tissue and ovarian endometrioma tissues have a different biology.
format	article
author	Ismail Biyik Uzeyir Kalkan Sercan Simsek
author_facet	Ismail Biyik Uzeyir Kalkan Sercan Simsek
author_sort	Ismail Biyik
title	The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue
title_short	The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue
title_full	The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue
title_fullStr	The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue
title_full_unstemmed	The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue
title_sort	deep infiltrating endometriosis tissue has lower t-cadherin, e-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/85f37972174b424da55c22c05590c1b1
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The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue

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