Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis
Intestinal dysbiosis is associated with an ever-growing list of autoimmune diseases. Here the authors show that both mice and humans with autoimmune arthritis can have dysbiosis and barrier leakiness prior to major signs of inflammatory arthritis, and treatment of mice with a zonulin antagonist can...
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Nature Portfolio
2020
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oai:doaj.org-article:85f50113935441358e580e8e7a413f862021-12-02T14:42:32ZTargeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis10.1038/s41467-020-15831-72041-1723https://doaj.org/article/85f50113935441358e580e8e7a413f862020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15831-7https://doaj.org/toc/2041-1723Intestinal dysbiosis is associated with an ever-growing list of autoimmune diseases. Here the authors show that both mice and humans with autoimmune arthritis can have dysbiosis and barrier leakiness prior to major signs of inflammatory arthritis, and treatment of mice with a zonulin antagonist can limit collagen-induced arthritis.Narges TajikMichael FrechOscar SchulzFabian SchälterSébastien LucasVugar AzizovKerstin DürholzFranziska SteffenYasunori OmataAndreas RingsMarko BertogAroldo RizzoAida IljazovicMarijana BasicArnd KleyerStephan CulemannGerhard KrönkeYubin LuoKlaus ÜberlaUdo S. GaiplBenjamin FreyTill StrowigKerstin SarterStephan C. BischoffStefan WirtzJuan D. CañeteFrancesco CicciaGeorg SchettMario M. ZaissNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Narges Tajik Michael Frech Oscar Schulz Fabian Schälter Sébastien Lucas Vugar Azizov Kerstin Dürholz Franziska Steffen Yasunori Omata Andreas Rings Marko Bertog Aroldo Rizzo Aida Iljazovic Marijana Basic Arnd Kleyer Stephan Culemann Gerhard Krönke Yubin Luo Klaus Überla Udo S. Gaipl Benjamin Frey Till Strowig Kerstin Sarter Stephan C. Bischoff Stefan Wirtz Juan D. Cañete Francesco Ciccia Georg Schett Mario M. Zaiss Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis |
| description |
Intestinal dysbiosis is associated with an ever-growing list of autoimmune diseases. Here the authors show that both mice and humans with autoimmune arthritis can have dysbiosis and barrier leakiness prior to major signs of inflammatory arthritis, and treatment of mice with a zonulin antagonist can limit collagen-induced arthritis. |
| format |
article |
| author |
Narges Tajik Michael Frech Oscar Schulz Fabian Schälter Sébastien Lucas Vugar Azizov Kerstin Dürholz Franziska Steffen Yasunori Omata Andreas Rings Marko Bertog Aroldo Rizzo Aida Iljazovic Marijana Basic Arnd Kleyer Stephan Culemann Gerhard Krönke Yubin Luo Klaus Überla Udo S. Gaipl Benjamin Frey Till Strowig Kerstin Sarter Stephan C. Bischoff Stefan Wirtz Juan D. Cañete Francesco Ciccia Georg Schett Mario M. Zaiss |
| author_facet |
Narges Tajik Michael Frech Oscar Schulz Fabian Schälter Sébastien Lucas Vugar Azizov Kerstin Dürholz Franziska Steffen Yasunori Omata Andreas Rings Marko Bertog Aroldo Rizzo Aida Iljazovic Marijana Basic Arnd Kleyer Stephan Culemann Gerhard Krönke Yubin Luo Klaus Überla Udo S. Gaipl Benjamin Frey Till Strowig Kerstin Sarter Stephan C. Bischoff Stefan Wirtz Juan D. Cañete Francesco Ciccia Georg Schett Mario M. Zaiss |
| author_sort |
Narges Tajik |
| title |
Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis |
| title_short |
Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis |
| title_full |
Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis |
| title_fullStr |
Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis |
| title_full_unstemmed |
Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis |
| title_sort |
targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/85f50113935441358e580e8e7a413f86 |
| work_keys_str_mv |
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