Joint Effect of Hepatic Steatosis and Alanine Aminotransferase Within the Normal Range on Incident Ischemic Heart Disease: A Prospective Study in Koreans

Dong-Hyuk Jung,1,2 Yong Jae Lee,3,4 Byoungjin Park1 1Department of Family Medicine, Yongin Severance Hospital, Yongin-si, Gyeonggi-do, 16995, Republic of Korea; 2Department of Health Promotion Centre, Yongin Severance Hospital, Yongin-si, Gyeonggi-do, 16995, Republic of Korea; 3Department of Family...

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Autores principales:	Jung DH, Lee YJ, Park B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	hepatic steatosis alanine aminotransferase prospective cohort study ischemic heart disease extrahepatic complication Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/85f53a68718e4559b52d6c52e74fe4ad
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spelling	oai:doaj.org-article:85f53a68718e4559b52d6c52e74fe4ad2021-12-02T17:06:25ZJoint Effect of Hepatic Steatosis and Alanine Aminotransferase Within the Normal Range on Incident Ischemic Heart Disease: A Prospective Study in Koreans1178-1998https://doaj.org/article/85f53a68718e4559b52d6c52e74fe4ad2021-03-01T00:00:00Zhttps://www.dovepress.com/joint-effect-of-hepatic-steatosis-and-alanine-aminotransferase-within--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Dong-Hyuk Jung,1,2 Yong Jae Lee,3,4 Byoungjin Park1 1Department of Family Medicine, Yongin Severance Hospital, Yongin-si, Gyeonggi-do, 16995, Republic of Korea; 2Department of Health Promotion Centre, Yongin Severance Hospital, Yongin-si, Gyeonggi-do, 16995, Republic of Korea; 3Department of Family Medicine, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea; 4Department of Family Medicine, Gangnam Severance Hospital, Seoul, 06273, Republic of KoreaCorrespondence: Byoungjin ParkDepartment of Family Medicine, Yonsei University College of Medicine, Yongin Severance Hospital, 363 Dongbaekjukjeondae-Ro, Giheung-Gu, Yongin-si, Gyeonggi-do, 16995, Republic of KoreaTel + 82 31 5189 8763Email bjpark96@yuhs.acPurpose: Hepatic steatosis has been associated with some cardiovascular risks. Increased alanine aminotransferase (ALT) was suggested to be linked to endothelial dysfunction. We prospectively investigated the joint effect of hepatic steatosis and elevated ALT within the normal range on incident ischemic heart disease (IHD) risk as an extrahepatic complication.Patients and Methods: We assessed 16,541 participants without diabetes using data from a health risk assessment study (HERAS) and Korean Health Insurance Review and Assessment (HIRA) data. We defined elevated ALT within the normal range as 30– 40 IU/L in men and 23– 40 IU/L in women, according to previous Korean epidemiological data. We prospectively assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD using multivariate Cox proportional hazards regression models over a 50-month period after the baseline survey.Results: During the follow-up period, 368 (2.2%) participants developed IHD. Compared to the group with no hepatic steatosis and controlled ALT, the HRs for IHD were 1.68 (95% CI, 1.16– 2.42) in the group with hepatic steatosis and elevated ALT after adjusting for confounding variables.Conclusion: Hepatic steatosis and elevated ALT levels within the normal range may jointly affect the development of IHD among nondiabetic adults. This indicates that lifestyle advice and vascular health management should be recommended among individuals with hepatic steatosis and elevated ALT, even if it falls within the normal range.Keywords: hepatic steatosis, alanine aminotransferase, prospective cohort study, ischemic heart disease, extrahepatic complicationJung DHLee YJPark BDove Medical Pressarticlehepatic steatosisalanine aminotransferaseprospective cohort studyischemic heart diseaseextrahepatic complicationGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 513-523 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatic steatosis alanine aminotransferase prospective cohort study ischemic heart disease extrahepatic complication Geriatrics RC952-954.6
spellingShingle	hepatic steatosis alanine aminotransferase prospective cohort study ischemic heart disease extrahepatic complication Geriatrics RC952-954.6 Jung DH Lee YJ Park B Joint Effect of Hepatic Steatosis and Alanine Aminotransferase Within the Normal Range on Incident Ischemic Heart Disease: A Prospective Study in Koreans
description	Dong-Hyuk Jung,1,2 Yong Jae Lee,3,4 Byoungjin Park1 1Department of Family Medicine, Yongin Severance Hospital, Yongin-si, Gyeonggi-do, 16995, Republic of Korea; 2Department of Health Promotion Centre, Yongin Severance Hospital, Yongin-si, Gyeonggi-do, 16995, Republic of Korea; 3Department of Family Medicine, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea; 4Department of Family Medicine, Gangnam Severance Hospital, Seoul, 06273, Republic of KoreaCorrespondence: Byoungjin ParkDepartment of Family Medicine, Yonsei University College of Medicine, Yongin Severance Hospital, 363 Dongbaekjukjeondae-Ro, Giheung-Gu, Yongin-si, Gyeonggi-do, 16995, Republic of KoreaTel + 82 31 5189 8763Email bjpark96@yuhs.acPurpose: Hepatic steatosis has been associated with some cardiovascular risks. Increased alanine aminotransferase (ALT) was suggested to be linked to endothelial dysfunction. We prospectively investigated the joint effect of hepatic steatosis and elevated ALT within the normal range on incident ischemic heart disease (IHD) risk as an extrahepatic complication.Patients and Methods: We assessed 16,541 participants without diabetes using data from a health risk assessment study (HERAS) and Korean Health Insurance Review and Assessment (HIRA) data. We defined elevated ALT within the normal range as 30– 40 IU/L in men and 23– 40 IU/L in women, according to previous Korean epidemiological data. We prospectively assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD using multivariate Cox proportional hazards regression models over a 50-month period after the baseline survey.Results: During the follow-up period, 368 (2.2%) participants developed IHD. Compared to the group with no hepatic steatosis and controlled ALT, the HRs for IHD were 1.68 (95% CI, 1.16– 2.42) in the group with hepatic steatosis and elevated ALT after adjusting for confounding variables.Conclusion: Hepatic steatosis and elevated ALT levels within the normal range may jointly affect the development of IHD among nondiabetic adults. This indicates that lifestyle advice and vascular health management should be recommended among individuals with hepatic steatosis and elevated ALT, even if it falls within the normal range.Keywords: hepatic steatosis, alanine aminotransferase, prospective cohort study, ischemic heart disease, extrahepatic complication
format	article
author	Jung DH Lee YJ Park B
author_facet	Jung DH Lee YJ Park B
author_sort	Jung DH
title	Joint Effect of Hepatic Steatosis and Alanine Aminotransferase Within the Normal Range on Incident Ischemic Heart Disease: A Prospective Study in Koreans
title_short	Joint Effect of Hepatic Steatosis and Alanine Aminotransferase Within the Normal Range on Incident Ischemic Heart Disease: A Prospective Study in Koreans
title_full	Joint Effect of Hepatic Steatosis and Alanine Aminotransferase Within the Normal Range on Incident Ischemic Heart Disease: A Prospective Study in Koreans
title_fullStr	Joint Effect of Hepatic Steatosis and Alanine Aminotransferase Within the Normal Range on Incident Ischemic Heart Disease: A Prospective Study in Koreans
title_full_unstemmed	Joint Effect of Hepatic Steatosis and Alanine Aminotransferase Within the Normal Range on Incident Ischemic Heart Disease: A Prospective Study in Koreans
title_sort	joint effect of hepatic steatosis and alanine aminotransferase within the normal range on incident ischemic heart disease: a prospective study in koreans
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/85f53a68718e4559b52d6c52e74fe4ad
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Joint Effect of Hepatic Steatosis and Alanine Aminotransferase Within the Normal Range on Incident Ischemic Heart Disease: A Prospective Study in Koreans

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