Better Medications Adherence Lowers Cardiovascular Events, Stroke, and All-Cause Mortality Risk: A Dose-Response Meta-Analysis

Aims: We investigated the association between vascular medication adherence, assessed by different methods, and the risk of cardio-cerebrovascular events and all-cause mortality. Methods: A meta-analysis with a systematic search of PubMed, Web of Science, EMBASE, and Cochrane databases from inceptio...

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Autores principales:	Mengying Liu, Guowei Zheng, Xiting Cao, Xinyu Chang, Ningning Zhang, Ge Liang, Anran Wang, Yan Yu, Yongli Yang, Yang Zhao, Xuezhong Shi, Dongsheng Hu, Jie Lu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	medication adherence cardiovascular events all-cause mortality meta-analysis dose-response Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/85f923c4bf3c43b994d24e246f31f160
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spelling	oai:doaj.org-article:85f923c4bf3c43b994d24e246f31f1602021-11-25T18:00:19ZBetter Medications Adherence Lowers Cardiovascular Events, Stroke, and All-Cause Mortality Risk: A Dose-Response Meta-Analysis10.3390/jcdd81101462308-3425https://doaj.org/article/85f923c4bf3c43b994d24e246f31f1602021-11-01T00:00:00Zhttps://www.mdpi.com/2308-3425/8/11/146https://doaj.org/toc/2308-3425Aims: We investigated the association between vascular medication adherence, assessed by different methods, and the risk of cardio-cerebrovascular events and all-cause mortality. Methods: A meta-analysis with a systematic search of PubMed, Web of Science, EMBASE, and Cochrane databases from inception date to 21 June 2021 was used to identify relevant studies that had evaluated the association between cardiovascular medication adherence levels and cardiovascular events (CVEs), stroke, and all-cause mortality risks. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated using a random-effects meta-analysis. Restricted cubic splines were used to model the dose-response association. Results: We identified 46 articles in the dose-response meta-analysis. The dose-response analysis indicated that a 20% increment in cardiovascular medication, antihypertensive medication, and lipid-lowering medication adherence level were associated with 9% (RR: 0.91, 95% CI 0.88–0.94), 7% (RR 0.93, 95% CI: 0.84–1.03), and 10% (RR 0.90, 95% CI: 0.88–0.92) lowers risk of CVEs, respectively. The reduced risk of stroke respectively was 16% (RR: 0.84, 95% CI: 0.81–0.87), 17% (RR 0.83, 95% CI: 0.78–0.89), and 13% (RR 0.87, 95% CI: 0.84–0.91). The reduced risk of all-cause mortality respectively was 10% (RR: 0.90, 95% CI: 0.87–0.92), 12% (RR 0.88, 95% CI: 0.82–0.94), and 9% (RR 0.91, 95% CI: 0.89–0.94). Conclusions: A better medication adherence level was associated with a reduced risk of cardio-cerebrovascular events and all-cause mortality.Mengying LiuGuowei ZhengXiting CaoXinyu ChangNingning ZhangGe LiangAnran WangYan YuYongli YangYang ZhaoXuezhong ShiDongsheng HuJie LuMDPI AGarticlemedication adherencecardiovascular eventsall-cause mortalitymeta-analysisdose-responseDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of Cardiovascular Development and Disease, Vol 8, Iss 146, p 146 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	medication adherence cardiovascular events all-cause mortality meta-analysis dose-response Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	medication adherence cardiovascular events all-cause mortality meta-analysis dose-response Diseases of the circulatory (Cardiovascular) system RC666-701 Mengying Liu Guowei Zheng Xiting Cao Xinyu Chang Ningning Zhang Ge Liang Anran Wang Yan Yu Yongli Yang Yang Zhao Xuezhong Shi Dongsheng Hu Jie Lu Better Medications Adherence Lowers Cardiovascular Events, Stroke, and All-Cause Mortality Risk: A Dose-Response Meta-Analysis
description	Aims: We investigated the association between vascular medication adherence, assessed by different methods, and the risk of cardio-cerebrovascular events and all-cause mortality. Methods: A meta-analysis with a systematic search of PubMed, Web of Science, EMBASE, and Cochrane databases from inception date to 21 June 2021 was used to identify relevant studies that had evaluated the association between cardiovascular medication adherence levels and cardiovascular events (CVEs), stroke, and all-cause mortality risks. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated using a random-effects meta-analysis. Restricted cubic splines were used to model the dose-response association. Results: We identified 46 articles in the dose-response meta-analysis. The dose-response analysis indicated that a 20% increment in cardiovascular medication, antihypertensive medication, and lipid-lowering medication adherence level were associated with 9% (RR: 0.91, 95% CI 0.88–0.94), 7% (RR 0.93, 95% CI: 0.84–1.03), and 10% (RR 0.90, 95% CI: 0.88–0.92) lowers risk of CVEs, respectively. The reduced risk of stroke respectively was 16% (RR: 0.84, 95% CI: 0.81–0.87), 17% (RR 0.83, 95% CI: 0.78–0.89), and 13% (RR 0.87, 95% CI: 0.84–0.91). The reduced risk of all-cause mortality respectively was 10% (RR: 0.90, 95% CI: 0.87–0.92), 12% (RR 0.88, 95% CI: 0.82–0.94), and 9% (RR 0.91, 95% CI: 0.89–0.94). Conclusions: A better medication adherence level was associated with a reduced risk of cardio-cerebrovascular events and all-cause mortality.
format	article
author	Mengying Liu Guowei Zheng Xiting Cao Xinyu Chang Ningning Zhang Ge Liang Anran Wang Yan Yu Yongli Yang Yang Zhao Xuezhong Shi Dongsheng Hu Jie Lu
author_facet	Mengying Liu Guowei Zheng Xiting Cao Xinyu Chang Ningning Zhang Ge Liang Anran Wang Yan Yu Yongli Yang Yang Zhao Xuezhong Shi Dongsheng Hu Jie Lu
author_sort	Mengying Liu
title	Better Medications Adherence Lowers Cardiovascular Events, Stroke, and All-Cause Mortality Risk: A Dose-Response Meta-Analysis
title_short	Better Medications Adherence Lowers Cardiovascular Events, Stroke, and All-Cause Mortality Risk: A Dose-Response Meta-Analysis
title_full	Better Medications Adherence Lowers Cardiovascular Events, Stroke, and All-Cause Mortality Risk: A Dose-Response Meta-Analysis
title_fullStr	Better Medications Adherence Lowers Cardiovascular Events, Stroke, and All-Cause Mortality Risk: A Dose-Response Meta-Analysis
title_full_unstemmed	Better Medications Adherence Lowers Cardiovascular Events, Stroke, and All-Cause Mortality Risk: A Dose-Response Meta-Analysis
title_sort	better medications adherence lowers cardiovascular events, stroke, and all-cause mortality risk: a dose-response meta-analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/85f923c4bf3c43b994d24e246f31f160
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Better Medications Adherence Lowers Cardiovascular Events, Stroke, and All-Cause Mortality Risk: A Dose-Response Meta-Analysis

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