Stability properties of underdominance in finite subdivided populations.

IN ISOLATED populations underdominance leads to bistable evolutionary dynamics: below a certain mutant allele frequency the wildtype succeeds. Above this point, the potentially underdominant mutant allele fixes. In subdivided populations with gene flow there can be stable states with coexistence of...

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Autores principales:	Philipp M Altrock, Arne Traulsen, Floyd A Reed
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/85fa4133772a43a490bcc62b594cd983
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spelling	oai:doaj.org-article:85fa4133772a43a490bcc62b594cd9832021-11-18T05:51:48ZStability properties of underdominance in finite subdivided populations.1553-734X1553-735810.1371/journal.pcbi.1002260https://doaj.org/article/85fa4133772a43a490bcc62b594cd9832011-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22072956/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358IN ISOLATED populations underdominance leads to bistable evolutionary dynamics: below a certain mutant allele frequency the wildtype succeeds. Above this point, the potentially underdominant mutant allele fixes. In subdivided populations with gene flow there can be stable states with coexistence of wildtypes and mutants: polymorphism can be maintained because of a migration-selection equilibrium, i.e., selection against rare recent immigrant alleles that tend to be heterozygous. We focus on the stochastic evolutionary dynamics of systems where demographic fluctuations in the coupled populations are the main source of internal noise. We discuss the influence of fitness, migration rate, and the relative sizes of two interacting populations on the mean extinction times of a group of potentially underdominant mutant alleles. We classify realistic initial conditions according to their impact on the stochastic extinction process. Even in small populations, where demographic fluctuations are large, stability properties predicted from deterministic dynamics show remarkable robustness. Fixation of the mutant allele becomes unlikely but the time to its extinction can be long.Philipp M AltrockArne TraulsenFloyd A ReedPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 7, Iss 11, p e1002260 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Philipp M Altrock Arne Traulsen Floyd A Reed Stability properties of underdominance in finite subdivided populations.
description	IN ISOLATED populations underdominance leads to bistable evolutionary dynamics: below a certain mutant allele frequency the wildtype succeeds. Above this point, the potentially underdominant mutant allele fixes. In subdivided populations with gene flow there can be stable states with coexistence of wildtypes and mutants: polymorphism can be maintained because of a migration-selection equilibrium, i.e., selection against rare recent immigrant alleles that tend to be heterozygous. We focus on the stochastic evolutionary dynamics of systems where demographic fluctuations in the coupled populations are the main source of internal noise. We discuss the influence of fitness, migration rate, and the relative sizes of two interacting populations on the mean extinction times of a group of potentially underdominant mutant alleles. We classify realistic initial conditions according to their impact on the stochastic extinction process. Even in small populations, where demographic fluctuations are large, stability properties predicted from deterministic dynamics show remarkable robustness. Fixation of the mutant allele becomes unlikely but the time to its extinction can be long.
format	article
author	Philipp M Altrock Arne Traulsen Floyd A Reed
author_facet	Philipp M Altrock Arne Traulsen Floyd A Reed
author_sort	Philipp M Altrock
title	Stability properties of underdominance in finite subdivided populations.
title_short	Stability properties of underdominance in finite subdivided populations.
title_full	Stability properties of underdominance in finite subdivided populations.
title_fullStr	Stability properties of underdominance in finite subdivided populations.
title_full_unstemmed	Stability properties of underdominance in finite subdivided populations.
title_sort	stability properties of underdominance in finite subdivided populations.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/85fa4133772a43a490bcc62b594cd983
work_keys_str_mv	AT philippmaltrock stabilitypropertiesofunderdominanceinfinitesubdividedpopulations AT arnetraulsen stabilitypropertiesofunderdominanceinfinitesubdividedpopulations AT floydareed stabilitypropertiesofunderdominanceinfinitesubdividedpopulations
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Stability properties of underdominance in finite subdivided populations.

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