ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells

Aging and inflammation: aging cells express interferon-stimulated genes in a non-canonical pathway Aging cells express many kinds of inflammation-related genes called SASP (senescence-associated secretary-phenotype), which are involved in aging-associated phenotypes. However, the underlying molecula...

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Autores principales:	Mari Yamagami, Motoyuki Otsuka, Takahiro Kishikawa, Kazuma Sekiba, Takahiro Seimiya, Eri Tanaka, Tatsunori Suzuki, Rei Ishibashi, Motoko Ohno, Kazuhiko Koike
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/85fad2daf73b4b2dacba3ae4e669a969
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spelling	oai:doaj.org-article:85fad2daf73b4b2dacba3ae4e669a9692021-12-02T14:22:33ZISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells10.1038/s41514-018-0030-62056-3973https://doaj.org/article/85fad2daf73b4b2dacba3ae4e669a9692018-11-01T00:00:00Zhttps://doi.org/10.1038/s41514-018-0030-6https://doaj.org/toc/2056-3973Aging and inflammation: aging cells express interferon-stimulated genes in a non-canonical pathway Aging cells express many kinds of inflammation-related genes called SASP (senescence-associated secretary-phenotype), which are involved in aging-associated phenotypes. However, the underlying molecular mechanisms how such inflammatory gene expression is induced in aging cells are unclear. A team led by Motoyuki Otsuka at the University of Tokyo found that using senescent human fibroblasts interferon-stimulated genes do not express in a canonical interferon-related intracellular signaling pathway. Normally, interferon-stimulated genes are expressed through the phosphorylation of STAT proteins triggered by interferon stimulation. In contrast, in senescent cells, interferon-stimulated genes were highly expressed without interferon stimulation and the representative STAT phosphorylation was not induced. These findings indicate that the interferon-stimulated genes in aging cells are expressed in a mechanism different from a canonical interferon-related pathway. Further research into these phenomena may develop a way to intervene the senescence-associated phenotypes in aging.Mari YamagamiMotoyuki OtsukaTakahiro KishikawaKazuma SekibaTakahiro SeimiyaEri TanakaTatsunori SuzukiRei IshibashiMotoko OhnoKazuhiko KoikeNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 4, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Mari Yamagami Motoyuki Otsuka Takahiro Kishikawa Kazuma Sekiba Takahiro Seimiya Eri Tanaka Tatsunori Suzuki Rei Ishibashi Motoko Ohno Kazuhiko Koike ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells
description	Aging and inflammation: aging cells express interferon-stimulated genes in a non-canonical pathway Aging cells express many kinds of inflammation-related genes called SASP (senescence-associated secretary-phenotype), which are involved in aging-associated phenotypes. However, the underlying molecular mechanisms how such inflammatory gene expression is induced in aging cells are unclear. A team led by Motoyuki Otsuka at the University of Tokyo found that using senescent human fibroblasts interferon-stimulated genes do not express in a canonical interferon-related intracellular signaling pathway. Normally, interferon-stimulated genes are expressed through the phosphorylation of STAT proteins triggered by interferon stimulation. In contrast, in senescent cells, interferon-stimulated genes were highly expressed without interferon stimulation and the representative STAT phosphorylation was not induced. These findings indicate that the interferon-stimulated genes in aging cells are expressed in a mechanism different from a canonical interferon-related pathway. Further research into these phenomena may develop a way to intervene the senescence-associated phenotypes in aging.
format	article
author	Mari Yamagami Motoyuki Otsuka Takahiro Kishikawa Kazuma Sekiba Takahiro Seimiya Eri Tanaka Tatsunori Suzuki Rei Ishibashi Motoko Ohno Kazuhiko Koike
author_facet	Mari Yamagami Motoyuki Otsuka Takahiro Kishikawa Kazuma Sekiba Takahiro Seimiya Eri Tanaka Tatsunori Suzuki Rei Ishibashi Motoko Ohno Kazuhiko Koike
author_sort	Mari Yamagami
title	ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells
title_short	ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells
title_full	ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells
title_fullStr	ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells
title_full_unstemmed	ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells
title_sort	isgf3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/85fad2daf73b4b2dacba3ae4e669a969
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ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells

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