NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress

Protein NEDDylation increases upon proteotoxic stress but the function of this response remains to be elucidated. Here, the authors show that NEDDylation contributes to the cellular defence against proteotoxicity by promoting nuclear protein aggregation and protecting the ubiquitin proteasome system...

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Autores principales:	Chantal M. Maghames, Sofia Lobato-Gil, Aurelien Perrin, Helene Trauchessec, Manuel S. Rodriguez, Serge Urbach, Philippe Marin, Dimitris P. Xirodimas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85faf55d5a3042e781053e60dc0a6572
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spelling	oai:doaj.org-article:85faf55d5a3042e781053e60dc0a65722021-12-02T16:56:52ZNEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress10.1038/s41467-018-06365-02041-1723https://doaj.org/article/85faf55d5a3042e781053e60dc0a65722018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06365-0https://doaj.org/toc/2041-1723Protein NEDDylation increases upon proteotoxic stress but the function of this response remains to be elucidated. Here, the authors show that NEDDylation contributes to the cellular defence against proteotoxicity by promoting nuclear protein aggregation and protecting the ubiquitin proteasome system.Chantal M. MaghamesSofia Lobato-GilAurelien PerrinHelene TrauchessecManuel S. RodriguezSerge UrbachPhilippe MarinDimitris P. XirodimasNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chantal M. Maghames Sofia Lobato-Gil Aurelien Perrin Helene Trauchessec Manuel S. Rodriguez Serge Urbach Philippe Marin Dimitris P. Xirodimas NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress
description	Protein NEDDylation increases upon proteotoxic stress but the function of this response remains to be elucidated. Here, the authors show that NEDDylation contributes to the cellular defence against proteotoxicity by promoting nuclear protein aggregation and protecting the ubiquitin proteasome system.
format	article
author	Chantal M. Maghames Sofia Lobato-Gil Aurelien Perrin Helene Trauchessec Manuel S. Rodriguez Serge Urbach Philippe Marin Dimitris P. Xirodimas
author_facet	Chantal M. Maghames Sofia Lobato-Gil Aurelien Perrin Helene Trauchessec Manuel S. Rodriguez Serge Urbach Philippe Marin Dimitris P. Xirodimas
author_sort	Chantal M. Maghames
title	NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress
title_short	NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress
title_full	NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress
title_fullStr	NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress
title_full_unstemmed	NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress
title_sort	neddylation promotes nuclear protein aggregation and protects the ubiquitin proteasome system upon proteotoxic stress
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/85faf55d5a3042e781053e60dc0a6572
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NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress

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