Psoriasis and inflammatory bowel disease: links and risks

Christoforos Vlachos,1 Georgios Gaitanis,1 Konstantinos H Katsanos,2 Dimitrios K Christodoulou,2 Epameinondas Tsianos,2 Ioannis D Bassukas1 1Department of Skin and Venereal Diseases, 2Division of Gastroenterology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Gree...

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Autores principales:	Vlachos C, Gaitanis G, Katsanos KH, Christodoulou DK, Tsianos E, Bassukas ID
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Psoriasis inflammatory bowel disease Crohn's disease ulcerative colitis immune cells inflammation Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/86017c3050fe4fcaae2dd99817f48fe6
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spelling	oai:doaj.org-article:86017c3050fe4fcaae2dd99817f48fe62021-12-02T03:11:51ZPsoriasis and inflammatory bowel disease: links and risks2230-326Xhttps://doaj.org/article/86017c3050fe4fcaae2dd99817f48fe62016-07-01T00:00:00Zhttps://www.dovepress.com/psoriasis-and-inflammatory-bowel-disease-links-and-risks-peer-reviewed-article-PTThttps://doaj.org/toc/2230-326XChristoforos Vlachos,1 Georgios Gaitanis,1 Konstantinos H Katsanos,2 Dimitrios K Christodoulou,2 Epameinondas Tsianos,2 Ioannis D Bassukas1 1Department of Skin and Venereal Diseases, 2Division of Gastroenterology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece Abstract: Psoriasis and the spectrum of inflammatory bowel diseases (IBD) are chronic, inflammatory, organotropic conditions. The epidemiologic coexistence of these diseases is corroborated by findings at the level of disease, biogeography, and intrafamilial and intrapatient coincidence. The identification of shared susceptibility loci and DNA polymorphisms has confirmed this correlation at a genetic level. The pathogenesis of both diseases implicates the innate and adaptive segments of the immune system. Increased permeability of the epidermal barrier in skin and intestine underlies the augmented interaction of allergens and pathogens with inflammatory receptors of immune cells. The immune response between psoriasis and IBD is similar and comprises phagocytic, dendritic, and natural killer cell, along with a milieu of cytokines and antimicrobial peptides that stimulate T-cells. The interplay between dendritic cells and Th17 cells appears to be the core dysregulated immune pathway in all these conditions. The distinct similarities in the pathogenesis are also reflected in the wide overlapping of their therapeutic approaches. Small-molecule pharmacologic immunomodulators have been applied, and more recently, biologic treatments that target proinflammatory interleukins have been introduced or are currently being evaluated. However, the fact that some treatments are quite selective for either skin or gut conditions also highlights their crucial pathophysiologic differences. In the present review, a comprehensive comparison of risk factors, pathogenesis links, and therapeutic strategies for psoriasis and IBD is presented. Specific emphasis is placed on the role of the immune cell species and inflammatory mediators participating in the pathogenesis of these diseases. Keywords: psoriasis, inflammatory bowel disease, Crohn’s disease, ulcerative colitis, immune cells, inflammationVlachos CGaitanis GKatsanos KHChristodoulou DKTsianos EBassukas IDDove Medical PressarticlePsoriasisinflammatory bowel diseaseCrohn's diseaseulcerative colitisimmune cellsinflammationDermatologyRL1-803ENPsoriasis: Targets and Therapy, Vol 2016, Iss Issue 1, Pp 73-92 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psoriasis inflammatory bowel disease Crohn's disease ulcerative colitis immune cells inflammation Dermatology RL1-803
spellingShingle	Psoriasis inflammatory bowel disease Crohn's disease ulcerative colitis immune cells inflammation Dermatology RL1-803 Vlachos C Gaitanis G Katsanos KH Christodoulou DK Tsianos E Bassukas ID Psoriasis and inflammatory bowel disease: links and risks
description	Christoforos Vlachos,1 Georgios Gaitanis,1 Konstantinos H Katsanos,2 Dimitrios K Christodoulou,2 Epameinondas Tsianos,2 Ioannis D Bassukas1 1Department of Skin and Venereal Diseases, 2Division of Gastroenterology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece Abstract: Psoriasis and the spectrum of inflammatory bowel diseases (IBD) are chronic, inflammatory, organotropic conditions. The epidemiologic coexistence of these diseases is corroborated by findings at the level of disease, biogeography, and intrafamilial and intrapatient coincidence. The identification of shared susceptibility loci and DNA polymorphisms has confirmed this correlation at a genetic level. The pathogenesis of both diseases implicates the innate and adaptive segments of the immune system. Increased permeability of the epidermal barrier in skin and intestine underlies the augmented interaction of allergens and pathogens with inflammatory receptors of immune cells. The immune response between psoriasis and IBD is similar and comprises phagocytic, dendritic, and natural killer cell, along with a milieu of cytokines and antimicrobial peptides that stimulate T-cells. The interplay between dendritic cells and Th17 cells appears to be the core dysregulated immune pathway in all these conditions. The distinct similarities in the pathogenesis are also reflected in the wide overlapping of their therapeutic approaches. Small-molecule pharmacologic immunomodulators have been applied, and more recently, biologic treatments that target proinflammatory interleukins have been introduced or are currently being evaluated. However, the fact that some treatments are quite selective for either skin or gut conditions also highlights their crucial pathophysiologic differences. In the present review, a comprehensive comparison of risk factors, pathogenesis links, and therapeutic strategies for psoriasis and IBD is presented. Specific emphasis is placed on the role of the immune cell species and inflammatory mediators participating in the pathogenesis of these diseases. Keywords: psoriasis, inflammatory bowel disease, Crohn’s disease, ulcerative colitis, immune cells, inflammation
format	article
author	Vlachos C Gaitanis G Katsanos KH Christodoulou DK Tsianos E Bassukas ID
author_facet	Vlachos C Gaitanis G Katsanos KH Christodoulou DK Tsianos E Bassukas ID
author_sort	Vlachos C
title	Psoriasis and inflammatory bowel disease: links and risks
title_short	Psoriasis and inflammatory bowel disease: links and risks
title_full	Psoriasis and inflammatory bowel disease: links and risks
title_fullStr	Psoriasis and inflammatory bowel disease: links and risks
title_full_unstemmed	Psoriasis and inflammatory bowel disease: links and risks
title_sort	psoriasis and inflammatory bowel disease: links and risks
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/86017c3050fe4fcaae2dd99817f48fe6
work_keys_str_mv	AT vlachosc psoriasisandinflammatoryboweldiseaselinksandrisks AT gaitanisg psoriasisandinflammatoryboweldiseaselinksandrisks AT katsanoskh psoriasisandinflammatoryboweldiseaselinksandrisks AT christodouloudk psoriasisandinflammatoryboweldiseaselinksandrisks AT tsianose psoriasisandinflammatoryboweldiseaselinksandrisks AT bassukasid psoriasisandinflammatoryboweldiseaselinksandrisks
_version_	1718401868727582720

Psoriasis and inflammatory bowel disease: links and risks

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