Radical asymmetric intramolecular α-cyclopropanation of aldehydes towards bicyclo[3.1.0]hexanes containing vicinal all-carbon quaternary stereocenters

Synthesis of cyclopropanes bearing vicinal all-carbon quaternary stereocenters poses synthetic challenges. Here, the authors report an intramolecular radical cyclopropanation with a copper/amine cooperative catalytic system for the efficient construction of bicyclo[3.1.0]hexane skeletons, also enant...

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Autores principales:	Liu Ye, Qiang-Shuai Gu, Yu Tian, Xiang Meng, Guo-Cong Chen, Xin-Yuan Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8602442574bc4ca48de23c7f726b17fb
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spelling	oai:doaj.org-article:8602442574bc4ca48de23c7f726b17fb2021-12-02T15:33:58ZRadical asymmetric intramolecular α-cyclopropanation of aldehydes towards bicyclo[3.1.0]hexanes containing vicinal all-carbon quaternary stereocenters10.1038/s41467-017-02231-72041-1723https://doaj.org/article/8602442574bc4ca48de23c7f726b17fb2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02231-7https://doaj.org/toc/2041-1723Synthesis of cyclopropanes bearing vicinal all-carbon quaternary stereocenters poses synthetic challenges. Here, the authors report an intramolecular radical cyclopropanation with a copper/amine cooperative catalytic system for the efficient construction of bicyclo[3.1.0]hexane skeletons, also enantioselectively.Liu YeQiang-Shuai GuYu TianXiang MengGuo-Cong ChenXin-Yuan LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liu Ye Qiang-Shuai Gu Yu Tian Xiang Meng Guo-Cong Chen Xin-Yuan Liu Radical asymmetric intramolecular α-cyclopropanation of aldehydes towards bicyclo[3.1.0]hexanes containing vicinal all-carbon quaternary stereocenters
description	Synthesis of cyclopropanes bearing vicinal all-carbon quaternary stereocenters poses synthetic challenges. Here, the authors report an intramolecular radical cyclopropanation with a copper/amine cooperative catalytic system for the efficient construction of bicyclo[3.1.0]hexane skeletons, also enantioselectively.
format	article
author	Liu Ye Qiang-Shuai Gu Yu Tian Xiang Meng Guo-Cong Chen Xin-Yuan Liu
author_facet	Liu Ye Qiang-Shuai Gu Yu Tian Xiang Meng Guo-Cong Chen Xin-Yuan Liu
author_sort	Liu Ye
title	Radical asymmetric intramolecular α-cyclopropanation of aldehydes towards bicyclo[3.1.0]hexanes containing vicinal all-carbon quaternary stereocenters
title_short	Radical asymmetric intramolecular α-cyclopropanation of aldehydes towards bicyclo[3.1.0]hexanes containing vicinal all-carbon quaternary stereocenters
title_full	Radical asymmetric intramolecular α-cyclopropanation of aldehydes towards bicyclo[3.1.0]hexanes containing vicinal all-carbon quaternary stereocenters
title_fullStr	Radical asymmetric intramolecular α-cyclopropanation of aldehydes towards bicyclo[3.1.0]hexanes containing vicinal all-carbon quaternary stereocenters
title_full_unstemmed	Radical asymmetric intramolecular α-cyclopropanation of aldehydes towards bicyclo[3.1.0]hexanes containing vicinal all-carbon quaternary stereocenters
title_sort	radical asymmetric intramolecular α-cyclopropanation of aldehydes towards bicyclo[3.1.0]hexanes containing vicinal all-carbon quaternary stereocenters
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8602442574bc4ca48de23c7f726b17fb
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_version_	1718386973116203008

Radical asymmetric intramolecular α-cyclopropanation of aldehydes towards bicyclo[3.1.0]hexanes containing vicinal all-carbon quaternary stereocenters

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