Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia

Abstract Clinical and prognostic differences between symptomatic and asymptomatic older patients with COVID-19 are of great interest since frail patients often show atypical presentation of illness. Lung Ultrasound (LUS) has been proven to be a reliable tool for detecting early-phase COVID-19 pneumo...

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Autores principales:	Chukwuma Okoye, Valeria Calsolaro, Alessandra Fabbri, Riccardo Franchi, Rachele Antognoli, Ludovica Zisca, Camilla Bianchi, Alessia Maria Calabrese, Sara Rogani, Fabio Monzani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8602594e6a9d4eab98448174d03bbeff
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spelling	oai:doaj.org-article:8602594e6a9d4eab98448174d03bbeff2021-11-28T12:20:53ZUsefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia10.1038/s41598-021-02275-22045-2322https://doaj.org/article/8602594e6a9d4eab98448174d03bbeff2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02275-2https://doaj.org/toc/2045-2322Abstract Clinical and prognostic differences between symptomatic and asymptomatic older patients with COVID-19 are of great interest since frail patients often show atypical presentation of illness. Lung Ultrasound (LUS) has been proven to be a reliable tool for detecting early-phase COVID-19 pneumonic alterations. The current prospective bicentric study aimed to compare LUS score and 3-month overall mortality between asymptomatic and symptomatic older patients with COVID-19, according to frailty status. Patients were stratified according to LUS score tertiles and Clinical Frailty Scale categories. Survival rate was assessed by telephone interviews 3 months after discharge. 64 symptomatic (24 women, aged 80.0 ± 10.8 years) and 46 asymptomatic (31 women, aged 84.3 ± 8.8 years) were consecutively enrolled. LUS score resulted an independent predictor of 3-month mortality [OR 2.27 (CI95% 1.09–4.8), p = 0.03], and the highest mortality rate was observed in symptomatic and asymptomatic pre-frail and frail patients (70.6% and 66.7%, respectively) with greater LUS abnormalities (3rd tertile). In conclusion, LUS identified an acute interstitial lung involvement in most of the older asymptomatic patients. Mortality rate progressively increased according to clinical frailty and LUS score degree, resulting a reliable prognostic tool in both symptomatic and asymptomatic patients.Chukwuma OkoyeValeria CalsolaroAlessandra FabbriRiccardo FranchiRachele AntognoliLudovica ZiscaCamilla BianchiAlessia Maria CalabreseSara RoganiFabio MonzaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chukwuma Okoye Valeria Calsolaro Alessandra Fabbri Riccardo Franchi Rachele Antognoli Ludovica Zisca Camilla Bianchi Alessia Maria Calabrese Sara Rogani Fabio Monzani Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia
description	Abstract Clinical and prognostic differences between symptomatic and asymptomatic older patients with COVID-19 are of great interest since frail patients often show atypical presentation of illness. Lung Ultrasound (LUS) has been proven to be a reliable tool for detecting early-phase COVID-19 pneumonic alterations. The current prospective bicentric study aimed to compare LUS score and 3-month overall mortality between asymptomatic and symptomatic older patients with COVID-19, according to frailty status. Patients were stratified according to LUS score tertiles and Clinical Frailty Scale categories. Survival rate was assessed by telephone interviews 3 months after discharge. 64 symptomatic (24 women, aged 80.0 ± 10.8 years) and 46 asymptomatic (31 women, aged 84.3 ± 8.8 years) were consecutively enrolled. LUS score resulted an independent predictor of 3-month mortality [OR 2.27 (CI95% 1.09–4.8), p = 0.03], and the highest mortality rate was observed in symptomatic and asymptomatic pre-frail and frail patients (70.6% and 66.7%, respectively) with greater LUS abnormalities (3rd tertile). In conclusion, LUS identified an acute interstitial lung involvement in most of the older asymptomatic patients. Mortality rate progressively increased according to clinical frailty and LUS score degree, resulting a reliable prognostic tool in both symptomatic and asymptomatic patients.
format	article
author	Chukwuma Okoye Valeria Calsolaro Alessandra Fabbri Riccardo Franchi Rachele Antognoli Ludovica Zisca Camilla Bianchi Alessia Maria Calabrese Sara Rogani Fabio Monzani
author_facet	Chukwuma Okoye Valeria Calsolaro Alessandra Fabbri Riccardo Franchi Rachele Antognoli Ludovica Zisca Camilla Bianchi Alessia Maria Calabrese Sara Rogani Fabio Monzani
author_sort	Chukwuma Okoye
title	Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia
title_short	Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia
title_full	Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia
title_fullStr	Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia
title_full_unstemmed	Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia
title_sort	usefulness of lung ultrasound for selecting asymptomatic older patients with covid 19 pneumonia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8602594e6a9d4eab98448174d03bbeff
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Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia

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