PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs

A large number of RNA binding proteins (RBPs) and miRNAs bind to the 3′ untranslated regions of mRNA, but methods to dissect their function and interactions are lacking. Here the authors introduce post-transcriptional regulatory element sequencing (PTRE-seq) to dissect sequence preferences, interact...

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Autores principales:	Kyle A. Cottrell, Hemangi G. Chaudhari, Barak A. Cohen, Sergej Djuranovic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/860a849ac3354dd6b652646c9de5a8c5
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id	oai:doaj.org-article:860a849ac3354dd6b652646c9de5a8c5
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spelling	oai:doaj.org-article:860a849ac3354dd6b652646c9de5a8c52021-12-02T16:49:33ZPTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs10.1038/s41467-017-02745-02041-1723https://doaj.org/article/860a849ac3354dd6b652646c9de5a8c52018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02745-0https://doaj.org/toc/2041-1723A large number of RNA binding proteins (RBPs) and miRNAs bind to the 3′ untranslated regions of mRNA, but methods to dissect their function and interactions are lacking. Here the authors introduce post-transcriptional regulatory element sequencing (PTRE-seq) to dissect sequence preferences, interactions and consequences of RBP and miRNA binding.Kyle A. CottrellHemangi G. ChaudhariBarak A. CohenSergej DjuranovicNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kyle A. Cottrell Hemangi G. Chaudhari Barak A. Cohen Sergej Djuranovic PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs
description	A large number of RNA binding proteins (RBPs) and miRNAs bind to the 3′ untranslated regions of mRNA, but methods to dissect their function and interactions are lacking. Here the authors introduce post-transcriptional regulatory element sequencing (PTRE-seq) to dissect sequence preferences, interactions and consequences of RBP and miRNA binding.
format	article
author	Kyle A. Cottrell Hemangi G. Chaudhari Barak A. Cohen Sergej Djuranovic
author_facet	Kyle A. Cottrell Hemangi G. Chaudhari Barak A. Cohen Sergej Djuranovic
author_sort	Kyle A. Cottrell
title	PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs
title_short	PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs
title_full	PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs
title_fullStr	PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs
title_full_unstemmed	PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs
title_sort	ptre-seq reveals mechanism and interactions of rna binding proteins and mirnas
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/860a849ac3354dd6b652646c9de5a8c5
work_keys_str_mv	AT kyleacottrell ptreseqrevealsmechanismandinteractionsofrnabindingproteinsandmirnas AT hemangigchaudhari ptreseqrevealsmechanismandinteractionsofrnabindingproteinsandmirnas AT barakacohen ptreseqrevealsmechanismandinteractionsofrnabindingproteinsandmirnas AT sergejdjuranovic ptreseqrevealsmechanismandinteractionsofrnabindingproteinsandmirnas
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PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs

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