Anti-Allergic Effect of Low Molecular Weight Digest from Abalone Viscera on Atopic Dermatitis-Induced NC/Nga

Abalone viscera (AV) is one of the byproducts of the seafood processing industry. The low molecular weight (<5 kDa) peptides (LMW-AV) obtained from gastrointestinal digestion of AV could suppress allergenic responses on activated HMC-1 human mast cells in our previous study. Regarding the allerge...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tae-Hee Kim, Seong-Yeong Heo, Gun-Woo Oh, Won Sun Park, Il-Whan Choi, Zhong-Ji Qian, Won-Kyo Jung
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	atopic dermatitis abalone viscera <i>Haliotis discus hannai</i> gastrointestinal digest <i>Dermatophagoides farina</i> Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/860b73cb4d5c43179c923089bcbefed2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:860b73cb4d5c43179c923089bcbefed2
record_format	dspace
spelling	oai:doaj.org-article:860b73cb4d5c43179c923089bcbefed22021-11-25T18:12:58ZAnti-Allergic Effect of Low Molecular Weight Digest from Abalone Viscera on Atopic Dermatitis-Induced NC/Nga10.3390/md191106341660-3397https://doaj.org/article/860b73cb4d5c43179c923089bcbefed22021-11-01T00:00:00Zhttps://www.mdpi.com/1660-3397/19/11/634https://doaj.org/toc/1660-3397Abalone viscera (AV) is one of the byproducts of the seafood processing industry. The low molecular weight (<5 kDa) peptides (LMW-AV) obtained from gastrointestinal digestion of AV could suppress allergenic responses on activated HMC-1 human mast cells in our previous study. Regarding the allergenic response of LMW-AV, in the present study, we further investigated the potential of oral administration of LMW-AV against atopic dermatitis (AD) in a dermatitis-induced model stimulated with <i>Dermatophagoides farinae</i>. The results demonstrated that the LMW-AV reduced a number of clinical symptoms, such as the severity of the dermatitis and serum immunoglobulin E levels. Moreover, LMW-AV could inhibit the expression of chemokines and cytokines. The histological analysis indicated that the LMW-AV has suppressed the eosinophil count and the mast cell infiltration into the upper dermis. The results suggest that LMW-AV can be considered as a promising candidate for AD treatment.Tae-Hee KimSeong-Yeong HeoGun-Woo OhWon Sun ParkIl-Whan ChoiZhong-Ji QianWon-Kyo JungMDPI AGarticleatopic dermatitisabalone viscera<i>Haliotis discus hannai</i>gastrointestinal digest<i>Dermatophagoides farina</i>Biology (General)QH301-705.5ENMarine Drugs, Vol 19, Iss 634, p 634 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atopic dermatitis abalone viscera <i>Haliotis discus hannai</i> gastrointestinal digest <i>Dermatophagoides farina</i> Biology (General) QH301-705.5
spellingShingle	atopic dermatitis abalone viscera <i>Haliotis discus hannai</i> gastrointestinal digest <i>Dermatophagoides farina</i> Biology (General) QH301-705.5 Tae-Hee Kim Seong-Yeong Heo Gun-Woo Oh Won Sun Park Il-Whan Choi Zhong-Ji Qian Won-Kyo Jung Anti-Allergic Effect of Low Molecular Weight Digest from Abalone Viscera on Atopic Dermatitis-Induced NC/Nga
description	Abalone viscera (AV) is one of the byproducts of the seafood processing industry. The low molecular weight (<5 kDa) peptides (LMW-AV) obtained from gastrointestinal digestion of AV could suppress allergenic responses on activated HMC-1 human mast cells in our previous study. Regarding the allergenic response of LMW-AV, in the present study, we further investigated the potential of oral administration of LMW-AV against atopic dermatitis (AD) in a dermatitis-induced model stimulated with <i>Dermatophagoides farinae</i>. The results demonstrated that the LMW-AV reduced a number of clinical symptoms, such as the severity of the dermatitis and serum immunoglobulin E levels. Moreover, LMW-AV could inhibit the expression of chemokines and cytokines. The histological analysis indicated that the LMW-AV has suppressed the eosinophil count and the mast cell infiltration into the upper dermis. The results suggest that LMW-AV can be considered as a promising candidate for AD treatment.
format	article
author	Tae-Hee Kim Seong-Yeong Heo Gun-Woo Oh Won Sun Park Il-Whan Choi Zhong-Ji Qian Won-Kyo Jung
author_facet	Tae-Hee Kim Seong-Yeong Heo Gun-Woo Oh Won Sun Park Il-Whan Choi Zhong-Ji Qian Won-Kyo Jung
author_sort	Tae-Hee Kim
title	Anti-Allergic Effect of Low Molecular Weight Digest from Abalone Viscera on Atopic Dermatitis-Induced NC/Nga
title_short	Anti-Allergic Effect of Low Molecular Weight Digest from Abalone Viscera on Atopic Dermatitis-Induced NC/Nga
title_full	Anti-Allergic Effect of Low Molecular Weight Digest from Abalone Viscera on Atopic Dermatitis-Induced NC/Nga
title_fullStr	Anti-Allergic Effect of Low Molecular Weight Digest from Abalone Viscera on Atopic Dermatitis-Induced NC/Nga
title_full_unstemmed	Anti-Allergic Effect of Low Molecular Weight Digest from Abalone Viscera on Atopic Dermatitis-Induced NC/Nga
title_sort	anti-allergic effect of low molecular weight digest from abalone viscera on atopic dermatitis-induced nc/nga
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/860b73cb4d5c43179c923089bcbefed2
work_keys_str_mv	AT taeheekim antiallergiceffectoflowmolecularweightdigestfromabalonevisceraonatopicdermatitisinducedncnga AT seongyeongheo antiallergiceffectoflowmolecularweightdigestfromabalonevisceraonatopicdermatitisinducedncnga AT gunwoooh antiallergiceffectoflowmolecularweightdigestfromabalonevisceraonatopicdermatitisinducedncnga AT wonsunpark antiallergiceffectoflowmolecularweightdigestfromabalonevisceraonatopicdermatitisinducedncnga AT ilwhanchoi antiallergiceffectoflowmolecularweightdigestfromabalonevisceraonatopicdermatitisinducedncnga AT zhongjiqian antiallergiceffectoflowmolecularweightdigestfromabalonevisceraonatopicdermatitisinducedncnga AT wonkyojung antiallergiceffectoflowmolecularweightdigestfromabalonevisceraonatopicdermatitisinducedncnga
_version_	1718411508168261632

Anti-Allergic Effect of Low Molecular Weight Digest from Abalone Viscera on Atopic Dermatitis-Induced NC/Nga

Ejemplares similares