A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria

A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria

The GTP-bound form of initiation factor 2 (IF2) promotes translation initiation by accelerating 50S ribosomal subunit joining the 30S ribosomal initiation complex (30S IC). Here the authors use single-molecule FRET and ensemble rapid kinetic methods to uncover the mechanism behind IF2-mediated subun...

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Autores principales: Kelvin Caban, Michael Pavlov, Måns Ehrenberg, Ruben L. Gonzalez
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/860cc1998dec4bbfa9a56eec475500c0
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spelling oai:doaj.org-article:860cc1998dec4bbfa9a56eec475500c02021-12-02T15:38:52ZA conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria10.1038/s41467-017-01492-62041-1723https://doaj.org/article/860cc1998dec4bbfa9a56eec475500c02017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01492-6https://doaj.org/toc/2041-1723The GTP-bound form of initiation factor 2 (IF2) promotes translation initiation by accelerating 50S ribosomal subunit joining the 30S ribosomal initiation complex (30S IC). Here the authors use single-molecule FRET and ensemble rapid kinetic methods to uncover the mechanism behind IF2-mediated subunit joining.Kelvin CabanMichael PavlovMåns EhrenbergRuben L. GonzalezNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kelvin Caban
Michael Pavlov
Måns Ehrenberg
Ruben L. Gonzalez
A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria
description The GTP-bound form of initiation factor 2 (IF2) promotes translation initiation by accelerating 50S ribosomal subunit joining the 30S ribosomal initiation complex (30S IC). Here the authors use single-molecule FRET and ensemble rapid kinetic methods to uncover the mechanism behind IF2-mediated subunit joining.
format article
author Kelvin Caban
Michael Pavlov
Måns Ehrenberg
Ruben L. Gonzalez
author_facet Kelvin Caban
Michael Pavlov
Måns Ehrenberg
Ruben L. Gonzalez
author_sort Kelvin Caban
title A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria
title_short A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria
title_full A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria
title_fullStr A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria
title_full_unstemmed A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria
title_sort conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/860cc1998dec4bbfa9a56eec475500c0
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