Role of adjuvant hormonal therapy in restoring reproductive function in women after endosurgical treatment of ovarian follicular cysts

In the structure of the causes of female infertility, follicular ovarian cysts make up 710% of cases. Despite the studies on the reproductive health of women undergoing endosurgical treatment of follicular ovarian cysts, the problem of restoring reproductive function has not yet been resolved. Ai...

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Autores principales:	Farkhad I. Shukurov, Farida M. Aiupova
Formato:	article
Lenguaje:	RU
Publicado:	IP Berlin A.V. 2021
Materias:	follicular ovarian cyst laparoscopy rehabilitation reproductive function ethinyl estradiol chlormadinone Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/8611965e1ca54756b38b6687bf438452
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spelling	oai:doaj.org-article:8611965e1ca54756b38b6687bf4384522021-12-02T19:22:24ZRole of adjuvant hormonal therapy in restoring reproductive function in women after endosurgical treatment of ovarian follicular cysts2079-56962079-583110.26442/20795696.2021.1.200441https://doaj.org/article/8611965e1ca54756b38b6687bf4384522021-03-01T00:00:00Zhttps://gynecology.orscience.ru/2079-5831/article/viewFile/63737/46701https://doaj.org/toc/2079-5696https://doaj.org/toc/2079-5831In the structure of the causes of female infertility, follicular ovarian cysts make up 710% of cases. Despite the studies on the reproductive health of women undergoing endosurgical treatment of follicular ovarian cysts, the problem of restoring reproductive function has not yet been resolved. Aim. To assess the effectiveness of a preparation containing 0.03 mg of ethinyl estradiol and 2 mg of chlormadinone acetate in the restoration of reproductive function in women after endosurgical treatment of follicular ovarian cysts. Materials and methods. The study group included 100 women, of whom 70 patients (the main group) received adjuvant therapy with a drug containing 0.03 mg of ethinyl estradiol and 2 mg of chlormadinone acetate after endosurgery, and a comparison group of 30 patients who did not receive adjuvant therapy. The diagnosis of follicular ovarian cysts was established on the basis of hormonal, ultrasound, endoscopic and immunohistochemical studies. The levels of gonadotropic hormones (LH, FSH), steroid hormones estradiol and progesterone were determined twice at the beginning of the follicular (35 day) and secretory phase (2022 day) of the menstrual cycle. An ovarian ultrasound was performed at the beginning of the follicular phase and on days 2022 of the menstrual cycle. Immunohistochemical studies of estrogen and progesterone receptors in the ovaries were carried out using a Bond-max immunostimulator from Leica (Germany) using monoclonal antibodies: clone 1D5 and clone 1A6 Dako (USA). Results. Menstrual irregularities were detected in 36 (51.4%) patients, of which: irregular menstruation in 18.0%, algomenorrhea in 15.1%, polymenorrhea in 11.0%, and menorrhea in 7.3% of patients, infertility was observed in 34 (48.6%) patients. Endosurgical treatment of follicular ovarian cysts was performed for all examined patients. Adjuvant hormone therapy with a drug containing 0.03 mg of ethinyl estradiol and 2 mg of chlormadinone acetate was received by 70 patients. Menstrual function was restored in 70 (100%) patients. Pregnancy occurred in 60 (86.0%) of them. Conclusion. Adjuvant hormone therapy with a drug containing 0.03 mg of ethinyl estradiol and 2 mg of chlormadinone acetate allowed to restore menstrual function (100% of cases), pregnancy at 4.3 times (86.0% of cases), which confirms its high efficiency in the restoration of reproductive function in women after endosurgical treatment of follicular ovarian cysts.Farkhad I. ShukurovFarida M. AiupovaIP Berlin A.V. articlefollicular ovarian cystlaparoscopyrehabilitationreproductive functionethinyl estradiolchlormadinoneGynecology and obstetricsRG1-991RUГинекология, Vol 23, Iss 1, Pp 68-72 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	follicular ovarian cyst laparoscopy rehabilitation reproductive function ethinyl estradiol chlormadinone Gynecology and obstetrics RG1-991
spellingShingle	follicular ovarian cyst laparoscopy rehabilitation reproductive function ethinyl estradiol chlormadinone Gynecology and obstetrics RG1-991 Farkhad I. Shukurov Farida M. Aiupova Role of adjuvant hormonal therapy in restoring reproductive function in women after endosurgical treatment of ovarian follicular cysts
description	In the structure of the causes of female infertility, follicular ovarian cysts make up 710% of cases. Despite the studies on the reproductive health of women undergoing endosurgical treatment of follicular ovarian cysts, the problem of restoring reproductive function has not yet been resolved. Aim. To assess the effectiveness of a preparation containing 0.03 mg of ethinyl estradiol and 2 mg of chlormadinone acetate in the restoration of reproductive function in women after endosurgical treatment of follicular ovarian cysts. Materials and methods. The study group included 100 women, of whom 70 patients (the main group) received adjuvant therapy with a drug containing 0.03 mg of ethinyl estradiol and 2 mg of chlormadinone acetate after endosurgery, and a comparison group of 30 patients who did not receive adjuvant therapy. The diagnosis of follicular ovarian cysts was established on the basis of hormonal, ultrasound, endoscopic and immunohistochemical studies. The levels of gonadotropic hormones (LH, FSH), steroid hormones estradiol and progesterone were determined twice at the beginning of the follicular (35 day) and secretory phase (2022 day) of the menstrual cycle. An ovarian ultrasound was performed at the beginning of the follicular phase and on days 2022 of the menstrual cycle. Immunohistochemical studies of estrogen and progesterone receptors in the ovaries were carried out using a Bond-max immunostimulator from Leica (Germany) using monoclonal antibodies: clone 1D5 and clone 1A6 Dako (USA). Results. Menstrual irregularities were detected in 36 (51.4%) patients, of which: irregular menstruation in 18.0%, algomenorrhea in 15.1%, polymenorrhea in 11.0%, and menorrhea in 7.3% of patients, infertility was observed in 34 (48.6%) patients. Endosurgical treatment of follicular ovarian cysts was performed for all examined patients. Adjuvant hormone therapy with a drug containing 0.03 mg of ethinyl estradiol and 2 mg of chlormadinone acetate was received by 70 patients. Menstrual function was restored in 70 (100%) patients. Pregnancy occurred in 60 (86.0%) of them. Conclusion. Adjuvant hormone therapy with a drug containing 0.03 mg of ethinyl estradiol and 2 mg of chlormadinone acetate allowed to restore menstrual function (100% of cases), pregnancy at 4.3 times (86.0% of cases), which confirms its high efficiency in the restoration of reproductive function in women after endosurgical treatment of follicular ovarian cysts.
format	article
author	Farkhad I. Shukurov Farida M. Aiupova
author_facet	Farkhad I. Shukurov Farida M. Aiupova
author_sort	Farkhad I. Shukurov
title	Role of adjuvant hormonal therapy in restoring reproductive function in women after endosurgical treatment of ovarian follicular cysts
title_short	Role of adjuvant hormonal therapy in restoring reproductive function in women after endosurgical treatment of ovarian follicular cysts
title_full	Role of adjuvant hormonal therapy in restoring reproductive function in women after endosurgical treatment of ovarian follicular cysts
title_fullStr	Role of adjuvant hormonal therapy in restoring reproductive function in women after endosurgical treatment of ovarian follicular cysts
title_full_unstemmed	Role of adjuvant hormonal therapy in restoring reproductive function in women after endosurgical treatment of ovarian follicular cysts
title_sort	role of adjuvant hormonal therapy in restoring reproductive function in women after endosurgical treatment of ovarian follicular cysts
publisher	IP Berlin A.V.
publishDate	2021
url	https://doaj.org/article/8611965e1ca54756b38b6687bf438452
work_keys_str_mv	AT farkhadishukurov roleofadjuvanthormonaltherapyinrestoringreproductivefunctioninwomenafterendosurgicaltreatmentofovarianfollicularcysts AT faridamaiupova roleofadjuvanthormonaltherapyinrestoringreproductivefunctioninwomenafterendosurgicaltreatmentofovarianfollicularcysts
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Role of adjuvant hormonal therapy in restoring reproductive function in women after endosurgical treatment of ovarian follicular cysts

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