Primary central nervous system Hodgkin Lymphoma: A case discussion and a hypothesis on the etiology

Hodgkin Lymphoma (HL) is a systemic disease with involvement of the cervical, supraclavicular, and mediastinal lymph nodes. It is commonly diagnosed in patients within the second and third decades of their lives. Diagnosis is usually made based on the distinct morphological and immunohistochemical c...

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Autores principales:	Ahmad Alfaseh, Mhd Nabeel Rajeh, Ghiath Hamed
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2019
Materias:	central nervous system lymphoma cerebellar tumor hodgkin lymphoma t-regulatory cells Medicine R
Acceso en línea:	https://doaj.org/article/8612282f3df34888b2e0ab68314f2a4f
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spelling	oai:doaj.org-article:8612282f3df34888b2e0ab68314f2a4f2021-12-02T17:58:44ZPrimary central nervous system Hodgkin Lymphoma: A case discussion and a hypothesis on the etiology2231-07702249-446410.4103/ajm.AJM_104_18https://doaj.org/article/8612282f3df34888b2e0ab68314f2a4f2019-01-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/ajm.AJM_104_18https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464Hodgkin Lymphoma (HL) is a systemic disease with involvement of the cervical, supraclavicular, and mediastinal lymph nodes. It is commonly diagnosed in patients within the second and third decades of their lives. Diagnosis is usually made based on the distinct morphological and immunohistochemical characteristics, with the tissue biopsy being the cornerstone of workup. Extranodal presentation of HL is unusual and seldom encountered. Primary HL of the central nervous system (CNS) is exceedingly rare. We herein report a case of a 38yearold male patient who was diagnosed with primary CNSHL. The patient was treated with complete surgical resection followed by radiotherapy and chemotherapy. The patient was diseasefree for 7 years postoperatively without any clinical evidence of relapse. We also discussed a possible role of CNS regulatory Tcells (Tregs) in developmental primary CNSHL.Ahmad AlfasehMhd Nabeel RajehGhiath HamedThieme Medical and Scientific Publishers Pvt. Ltd.articlecentral nervous system lymphomacerebellar tumorhodgkin lymphomat-regulatory cellsMedicineRENAvicenna Journal of Medicine, Vol 9, Iss 01, Pp 28-31 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	central nervous system lymphoma cerebellar tumor hodgkin lymphoma t-regulatory cells Medicine R
spellingShingle	central nervous system lymphoma cerebellar tumor hodgkin lymphoma t-regulatory cells Medicine R Ahmad Alfaseh Mhd Nabeel Rajeh Ghiath Hamed Primary central nervous system Hodgkin Lymphoma: A case discussion and a hypothesis on the etiology
description	Hodgkin Lymphoma (HL) is a systemic disease with involvement of the cervical, supraclavicular, and mediastinal lymph nodes. It is commonly diagnosed in patients within the second and third decades of their lives. Diagnosis is usually made based on the distinct morphological and immunohistochemical characteristics, with the tissue biopsy being the cornerstone of workup. Extranodal presentation of HL is unusual and seldom encountered. Primary HL of the central nervous system (CNS) is exceedingly rare. We herein report a case of a 38yearold male patient who was diagnosed with primary CNSHL. The patient was treated with complete surgical resection followed by radiotherapy and chemotherapy. The patient was diseasefree for 7 years postoperatively without any clinical evidence of relapse. We also discussed a possible role of CNS regulatory Tcells (Tregs) in developmental primary CNSHL.
format	article
author	Ahmad Alfaseh Mhd Nabeel Rajeh Ghiath Hamed
author_facet	Ahmad Alfaseh Mhd Nabeel Rajeh Ghiath Hamed
author_sort	Ahmad Alfaseh
title	Primary central nervous system Hodgkin Lymphoma: A case discussion and a hypothesis on the etiology
title_short	Primary central nervous system Hodgkin Lymphoma: A case discussion and a hypothesis on the etiology
title_full	Primary central nervous system Hodgkin Lymphoma: A case discussion and a hypothesis on the etiology
title_fullStr	Primary central nervous system Hodgkin Lymphoma: A case discussion and a hypothesis on the etiology
title_full_unstemmed	Primary central nervous system Hodgkin Lymphoma: A case discussion and a hypothesis on the etiology
title_sort	primary central nervous system hodgkin lymphoma: a case discussion and a hypothesis on the etiology
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2019
url	https://doaj.org/article/8612282f3df34888b2e0ab68314f2a4f
work_keys_str_mv	AT ahmadalfaseh primarycentralnervoussystemhodgkinlymphomaacasediscussionandahypothesisontheetiology AT mhdnabeelrajeh primarycentralnervoussystemhodgkinlymphomaacasediscussionandahypothesisontheetiology AT ghiathhamed primarycentralnervoussystemhodgkinlymphomaacasediscussionandahypothesisontheetiology
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Primary central nervous system Hodgkin Lymphoma: A case discussion and a hypothesis on the etiology

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