Highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations

Eder Lilia Romero, Maria Jose Morilla Nanomedicine Research Program, Department of Science and Technology, National University of Quilmes, Bernal, Buenos Aires, Argentina Abstract: Vesicles that are specifically designed to overcome the stratum corneum barrier in intact skin provide an efficient tra...

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Autores principales:	Romero EL, Morilla MJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8614d8309fbe4424985f2837601e6dad
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spelling	oai:doaj.org-article:8614d8309fbe4424985f2837601e6dad2021-12-02T06:38:06ZHighly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations1176-91141178-2013https://doaj.org/article/8614d8309fbe4424985f2837601e6dad2013-08-01T00:00:00Zhttp://www.dovepress.com/highly-deformable-and-highly-fluid-vesicles-as-potential-drug-delivery-a14106https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Eder Lilia Romero, Maria Jose Morilla Nanomedicine Research Program, Department of Science and Technology, National University of Quilmes, Bernal, Buenos Aires, Argentina Abstract: Vesicles that are specifically designed to overcome the stratum corneum barrier in intact skin provide an efficient transdermal (systemic or local) drug delivery system. They can be classified into two main groups according to the mechanisms underlying their skin interaction. The first group comprises those possessing highly deformable bilayers, achieved by incorporating edge activators to the bilayers or by mixing with certain hydrophilic solutes. The vesicles of this group act as drug carriers that penetrate across hydrophilic pathways of the intact skin. The second group comprises those possessing highly fluid bilayers, owing to the presence of permeation enhancers. The vesicles of this group can act as carriers of drugs that permeate the skin after the barrier of the stratum corneum is altered because of synergistic action with the permeation enhancers contained in the vesicle structure. We have included a detailed overview of the different mechanisms of skin interaction and discussed the most promising preclinical applications of the last five years of Transfersomes® (IDEA AG, Munich, Germany), ethosomes, and invasomes as carriers of antitumoral and anti-inflammatory drugs applied by the topical route. Keywords: Transfersomes, ethosomes, antitumoral, anti-inflammatory, topical deliveryRomero ELMorilla MJDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 3171-3186 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Romero EL Morilla MJ Highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations
description	Eder Lilia Romero, Maria Jose Morilla Nanomedicine Research Program, Department of Science and Technology, National University of Quilmes, Bernal, Buenos Aires, Argentina Abstract: Vesicles that are specifically designed to overcome the stratum corneum barrier in intact skin provide an efficient transdermal (systemic or local) drug delivery system. They can be classified into two main groups according to the mechanisms underlying their skin interaction. The first group comprises those possessing highly deformable bilayers, achieved by incorporating edge activators to the bilayers or by mixing with certain hydrophilic solutes. The vesicles of this group act as drug carriers that penetrate across hydrophilic pathways of the intact skin. The second group comprises those possessing highly fluid bilayers, owing to the presence of permeation enhancers. The vesicles of this group can act as carriers of drugs that permeate the skin after the barrier of the stratum corneum is altered because of synergistic action with the permeation enhancers contained in the vesicle structure. We have included a detailed overview of the different mechanisms of skin interaction and discussed the most promising preclinical applications of the last five years of Transfersomes® (IDEA AG, Munich, Germany), ethosomes, and invasomes as carriers of antitumoral and anti-inflammatory drugs applied by the topical route. Keywords: Transfersomes, ethosomes, antitumoral, anti-inflammatory, topical delivery
format	article
author	Romero EL Morilla MJ
author_facet	Romero EL Morilla MJ
author_sort	Romero EL
title	Highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations
title_short	Highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations
title_full	Highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations
title_fullStr	Highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations
title_full_unstemmed	Highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations
title_sort	highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/8614d8309fbe4424985f2837601e6dad
work_keys_str_mv	AT romeroel highlydeformableandhighlyfluidvesiclesaspotentialdrugdeliverysystemstheoreticalandpracticalconsiderations AT morillamj highlydeformableandhighlyfluidvesiclesaspotentialdrugdeliverysystemstheoreticalandpracticalconsiderations
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Highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations

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