Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010.

<h4>Background</h4>Depressive disorders were a leading cause of burden in the Global Burden of Disease (GBD) 1990 and 2000 studies. Here, we analyze the burden of depressive disorders in GBD 2010 and present severity proportions, burden by country, region, age, sex, and year, as well as...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alize J Ferrari, Fiona J Charlson, Rosana E Norman, Scott B Patten, Greg Freedman, Christopher J L Murray, Theo Vos, Harvey A Whiteford
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/8615ad2076e944d2a57d45d12eada308
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8615ad2076e944d2a57d45d12eada308
record_format	dspace
spelling	oai:doaj.org-article:8615ad2076e944d2a57d45d12eada3082021-11-18T05:43:05ZBurden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010.1549-12771549-167610.1371/journal.pmed.1001547https://doaj.org/article/8615ad2076e944d2a57d45d12eada3082013-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223526/pdf/?tool=EBIhttps://doaj.org/toc/1549-1277https://doaj.org/toc/1549-1676<h4>Background</h4>Depressive disorders were a leading cause of burden in the Global Burden of Disease (GBD) 1990 and 2000 studies. Here, we analyze the burden of depressive disorders in GBD 2010 and present severity proportions, burden by country, region, age, sex, and year, as well as burden of depressive disorders as a risk factor for suicide and ischemic heart disease.<h4>Methods and findings</h4>Burden was calculated for major depressive disorder (MDD) and dysthymia. A systematic review of epidemiological data was conducted. The data were pooled using a Bayesian meta-regression. Disability weights from population survey data quantified the severity of health loss from depressive disorders. These weights were used to calculate years lived with disability (YLDs) and disability adjusted life years (DALYs). Separate DALYs were estimated for suicide and ischemic heart disease attributable to depressive disorders. Depressive disorders were the second leading cause of YLDs in 2010. MDD accounted for 8.2% (5.9%-10.8%) of global YLDs and dysthymia for 1.4% (0.9%-2.0%). Depressive disorders were a leading cause of DALYs even though no mortality was attributed to them as the underlying cause. MDD accounted for 2.5% (1.9%-3.2%) of global DALYs and dysthymia for 0.5% (0.3%-0.6%). There was more regional variation in burden for MDD than for dysthymia; with higher estimates in females, and adults of working age. Whilst burden increased by 37.5% between 1990 and 2010, this was due to population growth and ageing. MDD explained 16 million suicide DALYs and almost 4 million ischemic heart disease DALYs. This attributable burden would increase the overall burden of depressive disorders from 3.0% (2.2%-3.8%) to 3.8% (3.0%-4.7%) of global DALYs.<h4>Conclusions</h4>GBD 2010 identified depressive disorders as a leading cause of burden. MDD was also a contributor of burden allocated to suicide and ischemic heart disease. These findings emphasize the importance of including depressive disorders as a public-health priority and implementing cost-effective interventions to reduce its burden. Please see later in the article for the Editors' Summary.Alize J FerrariFiona J CharlsonRosana E NormanScott B PattenGreg FreedmanChristopher J L MurrayTheo VosHarvey A WhitefordPublic Library of Science (PLoS)articleMedicineRENPLoS Medicine, Vol 10, Iss 11, p e1001547 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Alize J Ferrari Fiona J Charlson Rosana E Norman Scott B Patten Greg Freedman Christopher J L Murray Theo Vos Harvey A Whiteford Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010.
description	<h4>Background</h4>Depressive disorders were a leading cause of burden in the Global Burden of Disease (GBD) 1990 and 2000 studies. Here, we analyze the burden of depressive disorders in GBD 2010 and present severity proportions, burden by country, region, age, sex, and year, as well as burden of depressive disorders as a risk factor for suicide and ischemic heart disease.<h4>Methods and findings</h4>Burden was calculated for major depressive disorder (MDD) and dysthymia. A systematic review of epidemiological data was conducted. The data were pooled using a Bayesian meta-regression. Disability weights from population survey data quantified the severity of health loss from depressive disorders. These weights were used to calculate years lived with disability (YLDs) and disability adjusted life years (DALYs). Separate DALYs were estimated for suicide and ischemic heart disease attributable to depressive disorders. Depressive disorders were the second leading cause of YLDs in 2010. MDD accounted for 8.2% (5.9%-10.8%) of global YLDs and dysthymia for 1.4% (0.9%-2.0%). Depressive disorders were a leading cause of DALYs even though no mortality was attributed to them as the underlying cause. MDD accounted for 2.5% (1.9%-3.2%) of global DALYs and dysthymia for 0.5% (0.3%-0.6%). There was more regional variation in burden for MDD than for dysthymia; with higher estimates in females, and adults of working age. Whilst burden increased by 37.5% between 1990 and 2010, this was due to population growth and ageing. MDD explained 16 million suicide DALYs and almost 4 million ischemic heart disease DALYs. This attributable burden would increase the overall burden of depressive disorders from 3.0% (2.2%-3.8%) to 3.8% (3.0%-4.7%) of global DALYs.<h4>Conclusions</h4>GBD 2010 identified depressive disorders as a leading cause of burden. MDD was also a contributor of burden allocated to suicide and ischemic heart disease. These findings emphasize the importance of including depressive disorders as a public-health priority and implementing cost-effective interventions to reduce its burden. Please see later in the article for the Editors' Summary.
format	article
author	Alize J Ferrari Fiona J Charlson Rosana E Norman Scott B Patten Greg Freedman Christopher J L Murray Theo Vos Harvey A Whiteford
author_facet	Alize J Ferrari Fiona J Charlson Rosana E Norman Scott B Patten Greg Freedman Christopher J L Murray Theo Vos Harvey A Whiteford
author_sort	Alize J Ferrari
title	Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010.
title_short	Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010.
title_full	Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010.
title_fullStr	Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010.
title_full_unstemmed	Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010.
title_sort	burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/8615ad2076e944d2a57d45d12eada308
work_keys_str_mv	AT alizejferrari burdenofdepressivedisordersbycountrysexageandyearfindingsfromtheglobalburdenofdiseasestudy2010 AT fionajcharlson burdenofdepressivedisordersbycountrysexageandyearfindingsfromtheglobalburdenofdiseasestudy2010 AT rosanaenorman burdenofdepressivedisordersbycountrysexageandyearfindingsfromtheglobalburdenofdiseasestudy2010 AT scottbpatten burdenofdepressivedisordersbycountrysexageandyearfindingsfromtheglobalburdenofdiseasestudy2010 AT gregfreedman burdenofdepressivedisordersbycountrysexageandyearfindingsfromtheglobalburdenofdiseasestudy2010 AT christopherjlmurray burdenofdepressivedisordersbycountrysexageandyearfindingsfromtheglobalburdenofdiseasestudy2010 AT theovos burdenofdepressivedisordersbycountrysexageandyearfindingsfromtheglobalburdenofdiseasestudy2010 AT harveyawhiteford burdenofdepressivedisordersbycountrysexageandyearfindingsfromtheglobalburdenofdiseasestudy2010
_version_	1718424798175952896

Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010.

Ejemplares similares