Analyses of the relationship between hyperuricemia and osteoporosis

Abstract The aim of the present study was to evaluate the association between hyperuricemia and osteoporosis in a Korean population. Data from participants of the Korean Genome and Epidemiology Study who were ≥ 40 years old were collected from 2004 to 2016. Among 173,209 participants, 11,781 with hy...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jung Woo Lee, Bong Cheol Kwon, Hyo Geun Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8619c24e0a79485aa17a19ee1be404bf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8619c24e0a79485aa17a19ee1be404bf
record_format	dspace
spelling	oai:doaj.org-article:8619c24e0a79485aa17a19ee1be404bf2021-12-02T17:52:12ZAnalyses of the relationship between hyperuricemia and osteoporosis10.1038/s41598-021-91570-z2045-2322https://doaj.org/article/8619c24e0a79485aa17a19ee1be404bf2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91570-zhttps://doaj.org/toc/2045-2322Abstract The aim of the present study was to evaluate the association between hyperuricemia and osteoporosis in a Korean population. Data from participants of the Korean Genome and Epidemiology Study who were ≥ 40 years old were collected from 2004 to 2016. Among 173,209 participants, 11,781 with hyperuricemia (> 7.0 mg/dL in men and > 6.0 mg/dL in women) and 156,580 controls were selected based on serum measurements. Odds ratios (ORs) of osteoporosis between individuals with hyperuricemia and controls were analyzed using a logistic regression model. In the adjusted model, age, sex, income group, body mass index, smoking, alcohol consumption, hypertension, diabetes mellitus, hyperlipidemia history and nutritional intake were adjusted. The adjusted OR (aOR) of osteoporosis was 0.79 [95% confidence interval (CI) = 0.71–0.87, P < 0.001]. In subgroup analyses according to age and sex, statistical significance was observed in men > 60 years old and in women > 50 years old. In another subgroup analysis according to past medical history, significant differences were found according to hypertension (aOR = 0.83, 95% CI = 0.73–0.94, and 0.75, 95% CI = 0.64–0.87), diabetes mellitus (aOR = 0.77, 95% CI = 0.69–0.86), and hyperlipidemia (aOR = 0.74, 95% CI = 0.61–0.89, and 0.81, 95% CI = 0.72–0.91). This study demonstrated that hyperuricemia was associated with a decreased risk of osteoporosis.Jung Woo LeeBong Cheol KwonHyo Geun ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jung Woo Lee Bong Cheol Kwon Hyo Geun Choi Analyses of the relationship between hyperuricemia and osteoporosis
description	Abstract The aim of the present study was to evaluate the association between hyperuricemia and osteoporosis in a Korean population. Data from participants of the Korean Genome and Epidemiology Study who were ≥ 40 years old were collected from 2004 to 2016. Among 173,209 participants, 11,781 with hyperuricemia (> 7.0 mg/dL in men and > 6.0 mg/dL in women) and 156,580 controls were selected based on serum measurements. Odds ratios (ORs) of osteoporosis between individuals with hyperuricemia and controls were analyzed using a logistic regression model. In the adjusted model, age, sex, income group, body mass index, smoking, alcohol consumption, hypertension, diabetes mellitus, hyperlipidemia history and nutritional intake were adjusted. The adjusted OR (aOR) of osteoporosis was 0.79 [95% confidence interval (CI) = 0.71–0.87, P < 0.001]. In subgroup analyses according to age and sex, statistical significance was observed in men > 60 years old and in women > 50 years old. In another subgroup analysis according to past medical history, significant differences were found according to hypertension (aOR = 0.83, 95% CI = 0.73–0.94, and 0.75, 95% CI = 0.64–0.87), diabetes mellitus (aOR = 0.77, 95% CI = 0.69–0.86), and hyperlipidemia (aOR = 0.74, 95% CI = 0.61–0.89, and 0.81, 95% CI = 0.72–0.91). This study demonstrated that hyperuricemia was associated with a decreased risk of osteoporosis.
format	article
author	Jung Woo Lee Bong Cheol Kwon Hyo Geun Choi
author_facet	Jung Woo Lee Bong Cheol Kwon Hyo Geun Choi
author_sort	Jung Woo Lee
title	Analyses of the relationship between hyperuricemia and osteoporosis
title_short	Analyses of the relationship between hyperuricemia and osteoporosis
title_full	Analyses of the relationship between hyperuricemia and osteoporosis
title_fullStr	Analyses of the relationship between hyperuricemia and osteoporosis
title_full_unstemmed	Analyses of the relationship between hyperuricemia and osteoporosis
title_sort	analyses of the relationship between hyperuricemia and osteoporosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8619c24e0a79485aa17a19ee1be404bf
work_keys_str_mv	AT jungwoolee analysesoftherelationshipbetweenhyperuricemiaandosteoporosis AT bongcheolkwon analysesoftherelationshipbetweenhyperuricemiaandosteoporosis AT hyogeunchoi analysesoftherelationshipbetweenhyperuricemiaandosteoporosis
_version_	1718379237641027584

Analyses of the relationship between hyperuricemia and osteoporosis

Ejemplares similares