Molecular Pathogenesis of BCR-ABL-Negative Atypical Chronic Myeloid Leukemia

Atypical chronic myeloid leukemia is a rare disease whose pathogenesis has long been debated. It currently belongs to the group of myelodysplastic/myeloproliferative disorders. In this review, an overview on the current knowledge about diagnosis, prognosis, and genetics is presented, with a major fo...

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Autores principales:	Diletta Fontana, Carlo Gambacorti-Passerini, Rocco Piazza
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	aCML SETBP1 ETNK1 BCR-ABL1-negative molecular pathogenesis MDS/MPN Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/861bc3225c5d4c17958485b0290ca4f5
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spelling	oai:doaj.org-article:861bc3225c5d4c17958485b0290ca4f52021-11-11T05:00:55ZMolecular Pathogenesis of BCR-ABL-Negative Atypical Chronic Myeloid Leukemia2234-943X10.3389/fonc.2021.756348https://doaj.org/article/861bc3225c5d4c17958485b0290ca4f52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.756348/fullhttps://doaj.org/toc/2234-943XAtypical chronic myeloid leukemia is a rare disease whose pathogenesis has long been debated. It currently belongs to the group of myelodysplastic/myeloproliferative disorders. In this review, an overview on the current knowledge about diagnosis, prognosis, and genetics is presented, with a major focus on the recent molecular findings. We describe here the molecular pathogenesis of the disease, focusing on the mechanisms of action of the main mutations as well as on gene expression profiling. We also present the treatment options focusing on emerging targeted therapies.Diletta FontanaCarlo Gambacorti-PasseriniCarlo Gambacorti-PasseriniRocco PiazzaRocco PiazzaRocco PiazzaFrontiers Media S.A.articleaCMLSETBP1ETNK1BCR-ABL1-negativemolecular pathogenesisMDS/MPNNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aCML SETBP1 ETNK1 BCR-ABL1-negative molecular pathogenesis MDS/MPN Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	aCML SETBP1 ETNK1 BCR-ABL1-negative molecular pathogenesis MDS/MPN Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Diletta Fontana Carlo Gambacorti-Passerini Carlo Gambacorti-Passerini Rocco Piazza Rocco Piazza Rocco Piazza Molecular Pathogenesis of BCR-ABL-Negative Atypical Chronic Myeloid Leukemia
description	Atypical chronic myeloid leukemia is a rare disease whose pathogenesis has long been debated. It currently belongs to the group of myelodysplastic/myeloproliferative disorders. In this review, an overview on the current knowledge about diagnosis, prognosis, and genetics is presented, with a major focus on the recent molecular findings. We describe here the molecular pathogenesis of the disease, focusing on the mechanisms of action of the main mutations as well as on gene expression profiling. We also present the treatment options focusing on emerging targeted therapies.
format	article
author	Diletta Fontana Carlo Gambacorti-Passerini Carlo Gambacorti-Passerini Rocco Piazza Rocco Piazza Rocco Piazza
author_facet	Diletta Fontana Carlo Gambacorti-Passerini Carlo Gambacorti-Passerini Rocco Piazza Rocco Piazza Rocco Piazza
author_sort	Diletta Fontana
title	Molecular Pathogenesis of BCR-ABL-Negative Atypical Chronic Myeloid Leukemia
title_short	Molecular Pathogenesis of BCR-ABL-Negative Atypical Chronic Myeloid Leukemia
title_full	Molecular Pathogenesis of BCR-ABL-Negative Atypical Chronic Myeloid Leukemia
title_fullStr	Molecular Pathogenesis of BCR-ABL-Negative Atypical Chronic Myeloid Leukemia
title_full_unstemmed	Molecular Pathogenesis of BCR-ABL-Negative Atypical Chronic Myeloid Leukemia
title_sort	molecular pathogenesis of bcr-abl-negative atypical chronic myeloid leukemia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/861bc3225c5d4c17958485b0290ca4f5
work_keys_str_mv	AT dilettafontana molecularpathogenesisofbcrablnegativeatypicalchronicmyeloidleukemia AT carlogambacortipasserini molecularpathogenesisofbcrablnegativeatypicalchronicmyeloidleukemia AT carlogambacortipasserini molecularpathogenesisofbcrablnegativeatypicalchronicmyeloidleukemia AT roccopiazza molecularpathogenesisofbcrablnegativeatypicalchronicmyeloidleukemia AT roccopiazza molecularpathogenesisofbcrablnegativeatypicalchronicmyeloidleukemia AT roccopiazza molecularpathogenesisofbcrablnegativeatypicalchronicmyeloidleukemia
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Molecular Pathogenesis of BCR-ABL-Negative Atypical Chronic Myeloid Leukemia

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