Metal oxide nanoparticles interact with immune cells and activate different cellular responses

Rosana Simón-Vázquez, Tamara Lozano-Fernández, Angela Dávila-Grana, Africa González-Fernández Immunology Laboratory, Biomedical Research Center (CINBIO) and Institute of Biomedical Research of Ourense-Pontevedra-Vigo (IBI), Universit...

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Autores principales:	Simón-Vázquez R, Lozano-Fernández T, Dávila-Grana A, González-Fernández A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/861bf9c2a11545be83cefe7ed812dd1e
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spelling	oai:doaj.org-article:861bf9c2a11545be83cefe7ed812dd1e2021-12-02T04:27:08ZMetal oxide nanoparticles interact with immune cells and activate different cellular responses1178-2013https://doaj.org/article/861bf9c2a11545be83cefe7ed812dd1e2016-09-01T00:00:00Zhttps://www.dovepress.com/metal-oxide-nanoparticles-interact-with-immune-cells-and-activate-diff-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Rosana Simón-Vázquez, Tamara Lozano-Fernández, Angela Dávila-Grana, Africa González-Fernández Immunology Laboratory, Biomedical Research Center (CINBIO) and Institute of Biomedical Research of Ourense-Pontevedra-Vigo (IBI), University of Vigo, Campus Lagoas Marcosende, Vigo, Pontevedra, Spain Abstract: Besides cell death, nanoparticles (Nps) can induce other cellular responses such as inflammation. The potential immune response mediated by the exposure of human lymphoid cells to metal oxide Nps (moNps) was characterized using four different moNps (CeO2, TiO2, Al2O3, and ZnO) to study the three most relevant mitogen-activated protein kinase subfamilies and the nuclear factor kappa-light-chain-enhancer of the activated B-cell inhibitor, IκBα, as well as the expression of several genes by immune cells incubated with these Nps. The moNps activated different signaling pathways and altered the gene expression in human lymphocyte cells. The ZnO Nps were the most active and the release of Zn2+ ions was the main mechanism of toxicity. CeO2 Nps induced the smallest changes in gene expression and in the IκBα protein. The effects of the particles were strongly dependent on the type and concentration of the Nps and on the cell activation status prior to Np exposure. Keywords: Jurkat, MAPK, NFκB, qPCR, inflammation, metabolismSimón-Vázquez RLozano-Fernández TDávila-Grana AGonzález-Fernández ADove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 4657-4668 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Simón-Vázquez R Lozano-Fernández T Dávila-Grana A González-Fernández A Metal oxide nanoparticles interact with immune cells and activate different cellular responses
description	Rosana Simón-Vázquez, Tamara Lozano-Fernández, Angela Dávila-Grana, Africa González-Fernández Immunology Laboratory, Biomedical Research Center (CINBIO) and Institute of Biomedical Research of Ourense-Pontevedra-Vigo (IBI), University of Vigo, Campus Lagoas Marcosende, Vigo, Pontevedra, Spain Abstract: Besides cell death, nanoparticles (Nps) can induce other cellular responses such as inflammation. The potential immune response mediated by the exposure of human lymphoid cells to metal oxide Nps (moNps) was characterized using four different moNps (CeO2, TiO2, Al2O3, and ZnO) to study the three most relevant mitogen-activated protein kinase subfamilies and the nuclear factor kappa-light-chain-enhancer of the activated B-cell inhibitor, IκBα, as well as the expression of several genes by immune cells incubated with these Nps. The moNps activated different signaling pathways and altered the gene expression in human lymphocyte cells. The ZnO Nps were the most active and the release of Zn2+ ions was the main mechanism of toxicity. CeO2 Nps induced the smallest changes in gene expression and in the IκBα protein. The effects of the particles were strongly dependent on the type and concentration of the Nps and on the cell activation status prior to Np exposure. Keywords: Jurkat, MAPK, NFκB, qPCR, inflammation, metabolism
format	article
author	Simón-Vázquez R Lozano-Fernández T Dávila-Grana A González-Fernández A
author_facet	Simón-Vázquez R Lozano-Fernández T Dávila-Grana A González-Fernández A
author_sort	Simón-Vázquez R
title	Metal oxide nanoparticles interact with immune cells and activate different cellular responses
title_short	Metal oxide nanoparticles interact with immune cells and activate different cellular responses
title_full	Metal oxide nanoparticles interact with immune cells and activate different cellular responses
title_fullStr	Metal oxide nanoparticles interact with immune cells and activate different cellular responses
title_full_unstemmed	Metal oxide nanoparticles interact with immune cells and activate different cellular responses
title_sort	metal oxide nanoparticles interact with immune cells and activate different cellular responses
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/861bf9c2a11545be83cefe7ed812dd1e
work_keys_str_mv	AT simonvazquezr metaloxidenanoparticlesinteractwithimmunecellsandactivatedifferentcellularresponses AT lozanofernandezt metaloxidenanoparticlesinteractwithimmunecellsandactivatedifferentcellularresponses AT davilagranaa metaloxidenanoparticlesinteractwithimmunecellsandactivatedifferentcellularresponses AT gonzalezfernandeza metaloxidenanoparticlesinteractwithimmunecellsandactivatedifferentcellularresponses
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Metal oxide nanoparticles interact with immune cells and activate different cellular responses

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