Use it and improve it or lose it: interactions between arm function and use in humans post-stroke.

"Use it and improve it, or lose it" is one of the axioms of motor therapy after stroke. There is, however, little understanding of the interactions between arm function and use in humans post-stroke. Here, we explored putative non-linear interactions between upper extremity function and us...

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Autores principales:	Yukikazu Hidaka, Cheol E Han, Steven L Wolf, Carolee J Winstein, Nicolas Schweighofer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/861f7c0e994f45cca794731a266376d3
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spelling	oai:doaj.org-article:861f7c0e994f45cca794731a266376d32021-11-18T05:51:34ZUse it and improve it or lose it: interactions between arm function and use in humans post-stroke.1553-734X1553-735810.1371/journal.pcbi.1002343https://doaj.org/article/861f7c0e994f45cca794731a266376d32012-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22761551/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358"Use it and improve it, or lose it" is one of the axioms of motor therapy after stroke. There is, however, little understanding of the interactions between arm function and use in humans post-stroke. Here, we explored putative non-linear interactions between upper extremity function and use by developing a first-order dynamical model of stroke recovery with longitudinal data from participants receiving constraint induced movement therapy (CIMT) in the EXCITE clinical trial. Using a Bayesian regression framework, we systematically compared this model with competitive models that included, or not, interactions between function and use. Model comparisons showed that the model with the predicted interactions between arm function and use was the best fitting model. Furthermore, by comparing the model parameters before and after CIMT intervention in participants receiving the intervention one year after randomization, we found that therapy increased the parameter that controls the effect of arm function on arm use. Increase in this parameter, which can be thought of as the confidence to use the arm for a given level of function, lead to increase in spontaneous use after therapy compared to before therapy.Yukikazu HidakaCheol E HanSteven L WolfCarolee J WinsteinNicolas SchweighoferPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 8, Iss 2, p e1002343 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yukikazu Hidaka Cheol E Han Steven L Wolf Carolee J Winstein Nicolas Schweighofer Use it and improve it or lose it: interactions between arm function and use in humans post-stroke.
description	"Use it and improve it, or lose it" is one of the axioms of motor therapy after stroke. There is, however, little understanding of the interactions between arm function and use in humans post-stroke. Here, we explored putative non-linear interactions between upper extremity function and use by developing a first-order dynamical model of stroke recovery with longitudinal data from participants receiving constraint induced movement therapy (CIMT) in the EXCITE clinical trial. Using a Bayesian regression framework, we systematically compared this model with competitive models that included, or not, interactions between function and use. Model comparisons showed that the model with the predicted interactions between arm function and use was the best fitting model. Furthermore, by comparing the model parameters before and after CIMT intervention in participants receiving the intervention one year after randomization, we found that therapy increased the parameter that controls the effect of arm function on arm use. Increase in this parameter, which can be thought of as the confidence to use the arm for a given level of function, lead to increase in spontaneous use after therapy compared to before therapy.
format	article
author	Yukikazu Hidaka Cheol E Han Steven L Wolf Carolee J Winstein Nicolas Schweighofer
author_facet	Yukikazu Hidaka Cheol E Han Steven L Wolf Carolee J Winstein Nicolas Schweighofer
author_sort	Yukikazu Hidaka
title	Use it and improve it or lose it: interactions between arm function and use in humans post-stroke.
title_short	Use it and improve it or lose it: interactions between arm function and use in humans post-stroke.
title_full	Use it and improve it or lose it: interactions between arm function and use in humans post-stroke.
title_fullStr	Use it and improve it or lose it: interactions between arm function and use in humans post-stroke.
title_full_unstemmed	Use it and improve it or lose it: interactions between arm function and use in humans post-stroke.
title_sort	use it and improve it or lose it: interactions between arm function and use in humans post-stroke.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/861f7c0e994f45cca794731a266376d3
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Use it and improve it or lose it: interactions between arm function and use in humans post-stroke.

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