Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants

Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants

Antibodies (Abs) targeting highly conserved epitopes are important tools against emerging virus variants. Here, the authors characterize Abs that recognize a cryptic epitope in the receptor-binding domain of SARS-CoV-2 spike that is well conserved and show that these Abs can neutralize several varia...

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Autores principales: Tingting Li, Wenhui Xue, Qingbing Zheng, Shuo Song, Chuanlai Yang, Hualong Xiong, Sibo Zhang, Minqing Hong, Yali Zhang, Hai Yu, Yuyun Zhang, Hui Sun, Yang Huang, Tingting Deng, Xin Chi, Jinjin Li, Shaojuan Wang, Lizhi Zhou, Tingting Chen, Yingbin Wang, Tong Cheng, Tianying Zhang, Quan Yuan, Qinjian Zhao, Jun Zhang, Jason S. McLellan, Z. Hong Zhou, Zheng Zhang, Shaowei Li, Ying Gu, Ningshao Xia
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/86208d0971bf4ed2a80bc56f650c0589
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spelling oai:doaj.org-article:86208d0971bf4ed2a80bc56f650c05892021-12-02T18:51:16ZCross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants10.1038/s41467-021-25997-32041-1723https://doaj.org/article/86208d0971bf4ed2a80bc56f650c05892021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25997-3https://doaj.org/toc/2041-1723Antibodies (Abs) targeting highly conserved epitopes are important tools against emerging virus variants. Here, the authors characterize Abs that recognize a cryptic epitope in the receptor-binding domain of SARS-CoV-2 spike that is well conserved and show that these Abs can neutralize several variants of concerns.Tingting LiWenhui XueQingbing ZhengShuo SongChuanlai YangHualong XiongSibo ZhangMinqing HongYali ZhangHai YuYuyun ZhangHui SunYang HuangTingting DengXin ChiJinjin LiShaojuan WangLizhi ZhouTingting ChenYingbin WangTong ChengTianying ZhangQuan YuanQinjian ZhaoJun ZhangJason S. McLellanZ. Hong ZhouZheng ZhangShaowei LiYing GuNingshao XiaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tingting Li
Wenhui Xue
Qingbing Zheng
Shuo Song
Chuanlai Yang
Hualong Xiong
Sibo Zhang
Minqing Hong
Yali Zhang
Hai Yu
Yuyun Zhang
Hui Sun
Yang Huang
Tingting Deng
Xin Chi
Jinjin Li
Shaojuan Wang
Lizhi Zhou
Tingting Chen
Yingbin Wang
Tong Cheng
Tianying Zhang
Quan Yuan
Qinjian Zhao
Jun Zhang
Jason S. McLellan
Z. Hong Zhou
Zheng Zhang
Shaowei Li
Ying Gu
Ningshao Xia
Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants
description Antibodies (Abs) targeting highly conserved epitopes are important tools against emerging virus variants. Here, the authors characterize Abs that recognize a cryptic epitope in the receptor-binding domain of SARS-CoV-2 spike that is well conserved and show that these Abs can neutralize several variants of concerns.
format article
author Tingting Li
Wenhui Xue
Qingbing Zheng
Shuo Song
Chuanlai Yang
Hualong Xiong
Sibo Zhang
Minqing Hong
Yali Zhang
Hai Yu
Yuyun Zhang
Hui Sun
Yang Huang
Tingting Deng
Xin Chi
Jinjin Li
Shaojuan Wang
Lizhi Zhou
Tingting Chen
Yingbin Wang
Tong Cheng
Tianying Zhang
Quan Yuan
Qinjian Zhao
Jun Zhang
Jason S. McLellan
Z. Hong Zhou
Zheng Zhang
Shaowei Li
Ying Gu
Ningshao Xia
author_facet Tingting Li
Wenhui Xue
Qingbing Zheng
Shuo Song
Chuanlai Yang
Hualong Xiong
Sibo Zhang
Minqing Hong
Yali Zhang
Hai Yu
Yuyun Zhang
Hui Sun
Yang Huang
Tingting Deng
Xin Chi
Jinjin Li
Shaojuan Wang
Lizhi Zhou
Tingting Chen
Yingbin Wang
Tong Cheng
Tianying Zhang
Quan Yuan
Qinjian Zhao
Jun Zhang
Jason S. McLellan
Z. Hong Zhou
Zheng Zhang
Shaowei Li
Ying Gu
Ningshao Xia
author_sort Tingting Li
title Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants
title_short Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants
title_full Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants
title_fullStr Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants
title_full_unstemmed Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants
title_sort cross-neutralizing antibodies bind a sars-cov-2 cryptic site and resist circulating variants
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/86208d0971bf4ed2a80bc56f650c0589
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