A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts

Liliana Dell’Osso, Claudia Del Grande, Camilla Gesi, Claudia Carmassi, Laura Musetti Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy Abstract: Increasing evidence highlights bipolar disorder as being associated with impaired neurogenesis, cellular plasti...

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Autores principales:	Dell’Osso L, Del Grande C, Gesi C, Carmassi C, Musetti L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Lithium Bipolar Affective Disorder GSK-3 Neurodegeneration Neurogenesis. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/86258f644390421db4c1b550f19dd2b0
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spelling	oai:doaj.org-article:86258f644390421db4c1b550f19dd2b02021-12-02T06:05:46ZA new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts1178-2021https://doaj.org/article/86258f644390421db4c1b550f19dd2b02016-07-01T00:00:00Zhttps://www.dovepress.com/a-new-look-at-an-old-drug-neuroprotective-effects-and-therapeutic-pote-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Liliana Dell’Osso, Claudia Del Grande, Camilla Gesi, Claudia Carmassi, Laura Musetti Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy Abstract: Increasing evidence highlights bipolar disorder as being associated with impaired neurogenesis, cellular plasticity, and resiliency, as well as with cell atrophy or loss in specific brain regions. This has led most recent research to focus on the possible neuroprotective effects of medications, and particularly interesting findings have emerged for lithium. A growing body of evidence from preclinical in vitro and in vivo studies has in fact documented its neuroprotective effects from different insults acting on cellular signaling pathways, both preventing apoptosis and increasing neurotrophins and cell-survival molecules. Furthermore, positive effects of lithium on neurogenesis, brain remodeling, angiogenesis, mesenchymal stem cells functioning, and inflammation have been revealed, with a key role played through the inhibition of the glycogen synthase kinase-3, a serine/threonine kinase implicated in the pathogenesis of many neuropsychiatric disorders. These recent evidences suggest the potential utility of lithium in the treatment of neurodegenerative diseases, neurodevelopmental disorders, and hypoxic–ischemic/traumatic brain injury, with positive results at even lower lithium doses than those traditionally considered to be antimanic. The aim of this review is to briefly summarize the potential benefits of lithium salts on neuroprotection and neuroregeneration, emphasizing preclinical and clinical evidence suggesting new therapeutic potentials of this drug beyond its mood stabilizing properties. Keywords: bipolar disorder, GSK-3, neurodegeneration, neurogenesis, neurodevelopmental disordersDell’Osso LDel Grande CGesi CCarmassi CMusetti LDove Medical PressarticleLithiumBipolar Affective DisorderGSK-3NeurodegenerationNeurogenesis.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1687-1703 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lithium Bipolar Affective Disorder GSK-3 Neurodegeneration Neurogenesis. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Lithium Bipolar Affective Disorder GSK-3 Neurodegeneration Neurogenesis. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Dell’Osso L Del Grande C Gesi C Carmassi C Musetti L A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts
description	Liliana Dell’Osso, Claudia Del Grande, Camilla Gesi, Claudia Carmassi, Laura Musetti Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy Abstract: Increasing evidence highlights bipolar disorder as being associated with impaired neurogenesis, cellular plasticity, and resiliency, as well as with cell atrophy or loss in specific brain regions. This has led most recent research to focus on the possible neuroprotective effects of medications, and particularly interesting findings have emerged for lithium. A growing body of evidence from preclinical in vitro and in vivo studies has in fact documented its neuroprotective effects from different insults acting on cellular signaling pathways, both preventing apoptosis and increasing neurotrophins and cell-survival molecules. Furthermore, positive effects of lithium on neurogenesis, brain remodeling, angiogenesis, mesenchymal stem cells functioning, and inflammation have been revealed, with a key role played through the inhibition of the glycogen synthase kinase-3, a serine/threonine kinase implicated in the pathogenesis of many neuropsychiatric disorders. These recent evidences suggest the potential utility of lithium in the treatment of neurodegenerative diseases, neurodevelopmental disorders, and hypoxic–ischemic/traumatic brain injury, with positive results at even lower lithium doses than those traditionally considered to be antimanic. The aim of this review is to briefly summarize the potential benefits of lithium salts on neuroprotection and neuroregeneration, emphasizing preclinical and clinical evidence suggesting new therapeutic potentials of this drug beyond its mood stabilizing properties. Keywords: bipolar disorder, GSK-3, neurodegeneration, neurogenesis, neurodevelopmental disorders
format	article
author	Dell’Osso L Del Grande C Gesi C Carmassi C Musetti L
author_facet	Dell’Osso L Del Grande C Gesi C Carmassi C Musetti L
author_sort	Dell’Osso L
title	A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts
title_short	A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts
title_full	A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts
title_fullStr	A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts
title_full_unstemmed	A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts
title_sort	new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/86258f644390421db4c1b550f19dd2b0
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A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts

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