Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing

Abstract Psychedelic microdosing describes the ingestion of near-threshold perceptible doses of classic psychedelic substances. Anecdotal reports and observational studies suggest that microdosing may promote positive mood and well-being, but recent placebo-controlled studies failed to find compelli...

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Autores principales:	L. S. Kaertner, M. B. Steinborn, H. Kettner, M. J. Spriggs, L. Roseman, T. Buchborn, M. Balaet, C. Timmermann, D. Erritzoe, R. L. Carhart-Harris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/862a9538a53e46f8b4f5db764e39142f
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spelling	oai:doaj.org-article:862a9538a53e46f8b4f5db764e39142f2021-12-02T13:51:15ZPositive expectations predict improved mental-health outcomes linked to psychedelic microdosing10.1038/s41598-021-81446-72045-2322https://doaj.org/article/862a9538a53e46f8b4f5db764e39142f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81446-7https://doaj.org/toc/2045-2322Abstract Psychedelic microdosing describes the ingestion of near-threshold perceptible doses of classic psychedelic substances. Anecdotal reports and observational studies suggest that microdosing may promote positive mood and well-being, but recent placebo-controlled studies failed to find compelling evidence for this. The present study collected web-based mental health and related data using a prospective (before, during and after) design. Individuals planning a weekly microdosing regimen completed surveys at strategic timepoints, spanning a core four-week test period. Eighty-one participants completed the primary study endpoint. Results revealed increased self-reported psychological well-being, emotional stability and reductions in state anxiety and depressive symptoms at the four-week primary endpoint, plus increases in psychological resilience, social connectedness, agreeableness, nature relatedness and aspects of psychological flexibility. However, positive expectancy scores at baseline predicted subsequent improvements in well-being, suggestive of a significant placebo response. This study highlights a role for positive expectancy in predicting positive outcomes following psychedelic microdosing and cautions against zealous inferences on its putative therapeutic value.L. S. KaertnerM. B. SteinbornH. KettnerM. J. SpriggsL. RosemanT. BuchbornM. BalaetC. TimmermannD. ErritzoeR. L. Carhart-HarrisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q L. S. Kaertner M. B. Steinborn H. Kettner M. J. Spriggs L. Roseman T. Buchborn M. Balaet C. Timmermann D. Erritzoe R. L. Carhart-Harris Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing
description	Abstract Psychedelic microdosing describes the ingestion of near-threshold perceptible doses of classic psychedelic substances. Anecdotal reports and observational studies suggest that microdosing may promote positive mood and well-being, but recent placebo-controlled studies failed to find compelling evidence for this. The present study collected web-based mental health and related data using a prospective (before, during and after) design. Individuals planning a weekly microdosing regimen completed surveys at strategic timepoints, spanning a core four-week test period. Eighty-one participants completed the primary study endpoint. Results revealed increased self-reported psychological well-being, emotional stability and reductions in state anxiety and depressive symptoms at the four-week primary endpoint, plus increases in psychological resilience, social connectedness, agreeableness, nature relatedness and aspects of psychological flexibility. However, positive expectancy scores at baseline predicted subsequent improvements in well-being, suggestive of a significant placebo response. This study highlights a role for positive expectancy in predicting positive outcomes following psychedelic microdosing and cautions against zealous inferences on its putative therapeutic value.
format	article
author	L. S. Kaertner M. B. Steinborn H. Kettner M. J. Spriggs L. Roseman T. Buchborn M. Balaet C. Timmermann D. Erritzoe R. L. Carhart-Harris
author_facet	L. S. Kaertner M. B. Steinborn H. Kettner M. J. Spriggs L. Roseman T. Buchborn M. Balaet C. Timmermann D. Erritzoe R. L. Carhart-Harris
author_sort	L. S. Kaertner
title	Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing
title_short	Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing
title_full	Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing
title_fullStr	Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing
title_full_unstemmed	Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing
title_sort	positive expectations predict improved mental-health outcomes linked to psychedelic microdosing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/862a9538a53e46f8b4f5db764e39142f
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Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing

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