Alterations of total antioxidant capacity of pathogen cultures under the influence of novel chemical compounds

Introduction. The major and most common mechanisms for almost all antimicrobial substances is the induction of oxidative stress responses within the pathogen cells by accumulation of free radicals, which mediate a whole range of classical antimicrobial mechanisms of action observed by researchers. T...

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Autor principal: Carolina LOZAN-TIRSU
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Publicado: Asociatia de Biosiguranta si Biosecuritate 2020
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spelling oai:doaj.org-article:862afd98b40c4599b4b1d86c7fc7663e2021-12-02T14:17:33ZAlterations of total antioxidant capacity of pathogen cultures under the influence of novel chemical compounds10.38045/ohrm.2020.1.162887-34582587-3466https://doaj.org/article/862afd98b40c4599b4b1d86c7fc7663e2020-10-01T00:00:00Zhttps://journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/article/view/72/37https://doaj.org/toc/2887-3458https://doaj.org/toc/2587-3466Introduction. The major and most common mechanisms for almost all antimicrobial substances is the induction of oxidative stress responses within the pathogen cells by accumulation of free radicals, which mediate a whole range of classical antimicrobial mechanisms of action observed by researchers. Thus, this present study was conducted to reveal some biochemical changes regarding the antioxidant status of pathogenic microorganisms under the influence of novel chemical compounds selected. Material and methods. The copper (II) coordination compounds were included as in vitro study material, namely, Co (II), Zn (II) and aromatic propenones, synthesized at the Department of Inorganic Chemistry, the State University of Moldova. The antimicrobial properties were tested on five reference strains. The ABTS test was applied to determine the antioxidant activity, thus determining the total antioxidant capacity using the ABTS˙+ cation radical. Results. The most vulnerable to high-intensity oxidative stress are the reference strains of Staphylococcus aureus ATCC 2592 and Bacillus cereus ГИСК 8035, the most resistant being the reference culture Salmonella enterica (S. Abony ГИСК 03/03y). Conclusions. The study results showed that the selected compounds might substantially reduce the total antioxidant capacity in the studied reference cultures.Carolina LOZAN-TIRSUAsociatia de Biosiguranta si Biosecuritatearticleantimicrobial activityantioxidant activitychemical compoundscopperreference strainsMedicineRScienceQENFRRORUOne Health & Risk Management, Vol 1, Iss 2, Pp 50-57 (2020)
institution DOAJ
collection DOAJ
language EN
FR
RO
RU
topic antimicrobial activity
antioxidant activity
chemical compounds
copper
reference strains
Medicine
R
Science
Q
spellingShingle antimicrobial activity
antioxidant activity
chemical compounds
copper
reference strains
Medicine
R
Science
Q
Carolina LOZAN-TIRSU
Alterations of total antioxidant capacity of pathogen cultures under the influence of novel chemical compounds
description Introduction. The major and most common mechanisms for almost all antimicrobial substances is the induction of oxidative stress responses within the pathogen cells by accumulation of free radicals, which mediate a whole range of classical antimicrobial mechanisms of action observed by researchers. Thus, this present study was conducted to reveal some biochemical changes regarding the antioxidant status of pathogenic microorganisms under the influence of novel chemical compounds selected. Material and methods. The copper (II) coordination compounds were included as in vitro study material, namely, Co (II), Zn (II) and aromatic propenones, synthesized at the Department of Inorganic Chemistry, the State University of Moldova. The antimicrobial properties were tested on five reference strains. The ABTS test was applied to determine the antioxidant activity, thus determining the total antioxidant capacity using the ABTS˙+ cation radical. Results. The most vulnerable to high-intensity oxidative stress are the reference strains of Staphylococcus aureus ATCC 2592 and Bacillus cereus ГИСК 8035, the most resistant being the reference culture Salmonella enterica (S. Abony ГИСК 03/03y). Conclusions. The study results showed that the selected compounds might substantially reduce the total antioxidant capacity in the studied reference cultures.
format article
author Carolina LOZAN-TIRSU
author_facet Carolina LOZAN-TIRSU
author_sort Carolina LOZAN-TIRSU
title Alterations of total antioxidant capacity of pathogen cultures under the influence of novel chemical compounds
title_short Alterations of total antioxidant capacity of pathogen cultures under the influence of novel chemical compounds
title_full Alterations of total antioxidant capacity of pathogen cultures under the influence of novel chemical compounds
title_fullStr Alterations of total antioxidant capacity of pathogen cultures under the influence of novel chemical compounds
title_full_unstemmed Alterations of total antioxidant capacity of pathogen cultures under the influence of novel chemical compounds
title_sort alterations of total antioxidant capacity of pathogen cultures under the influence of novel chemical compounds
publisher Asociatia de Biosiguranta si Biosecuritate
publishDate 2020
url https://doaj.org/article/862afd98b40c4599b4b1d86c7fc7663e
work_keys_str_mv AT carolinalozantirsu alterationsoftotalantioxidantcapacityofpathogenculturesundertheinfluenceofnovelchemicalcompounds
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