Cerebral tissue pO2 response to treadmill exercise in awake mice

Abstract We exploited two-photon microscopy and Doppler optical coherence tomography to examine the cerebral blood flow and tissue pO2 response to forced treadmill exercise in awake mice. To our knowledge, this is the first study performing both direct measure of brain tissue pO2 during acute forced...

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Autores principales:	Mohammad Moeini, Christophe Cloutier-Tremblay, Xuecong Lu, Ashok Kakkar, Frédéric Lesage
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8631f003d170479bbc1fd94094ebcd1e
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spelling	oai:doaj.org-article:8631f003d170479bbc1fd94094ebcd1e2021-12-02T16:36:36ZCerebral tissue pO2 response to treadmill exercise in awake mice10.1038/s41598-020-70413-32045-2322https://doaj.org/article/8631f003d170479bbc1fd94094ebcd1e2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-70413-3https://doaj.org/toc/2045-2322Abstract We exploited two-photon microscopy and Doppler optical coherence tomography to examine the cerebral blood flow and tissue pO2 response to forced treadmill exercise in awake mice. To our knowledge, this is the first study performing both direct measure of brain tissue pO2 during acute forced exercise and underlying microvascular response at capillary and non-capillary levels. We observed that cerebral perfusion and oxygenation are enhanced during running at 5 m/min compared to rest. At faster running speeds (10 and 15 m/min), decreasing trends in arteriolar and capillary flow speed were observed, which could be due to cerebral autoregulation and constriction of arterioles in response to blood pressure increase. However, tissue pO2 was maintained, likely due to an increase in RBC linear density. Higher cerebral oxygenation at exercise levels 5–15 m/min suggests beneficial effects of exercise in situations where oxygen delivery to the brain is compromised, such as in aging, atherosclerosis and Alzheimer Disease.Mohammad MoeiniChristophe Cloutier-TremblayXuecong LuAshok KakkarFrédéric LesageNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohammad Moeini Christophe Cloutier-Tremblay Xuecong Lu Ashok Kakkar Frédéric Lesage Cerebral tissue pO2 response to treadmill exercise in awake mice
description	Abstract We exploited two-photon microscopy and Doppler optical coherence tomography to examine the cerebral blood flow and tissue pO2 response to forced treadmill exercise in awake mice. To our knowledge, this is the first study performing both direct measure of brain tissue pO2 during acute forced exercise and underlying microvascular response at capillary and non-capillary levels. We observed that cerebral perfusion and oxygenation are enhanced during running at 5 m/min compared to rest. At faster running speeds (10 and 15 m/min), decreasing trends in arteriolar and capillary flow speed were observed, which could be due to cerebral autoregulation and constriction of arterioles in response to blood pressure increase. However, tissue pO2 was maintained, likely due to an increase in RBC linear density. Higher cerebral oxygenation at exercise levels 5–15 m/min suggests beneficial effects of exercise in situations where oxygen delivery to the brain is compromised, such as in aging, atherosclerosis and Alzheimer Disease.
format	article
author	Mohammad Moeini Christophe Cloutier-Tremblay Xuecong Lu Ashok Kakkar Frédéric Lesage
author_facet	Mohammad Moeini Christophe Cloutier-Tremblay Xuecong Lu Ashok Kakkar Frédéric Lesage
author_sort	Mohammad Moeini
title	Cerebral tissue pO2 response to treadmill exercise in awake mice
title_short	Cerebral tissue pO2 response to treadmill exercise in awake mice
title_full	Cerebral tissue pO2 response to treadmill exercise in awake mice
title_fullStr	Cerebral tissue pO2 response to treadmill exercise in awake mice
title_full_unstemmed	Cerebral tissue pO2 response to treadmill exercise in awake mice
title_sort	cerebral tissue po2 response to treadmill exercise in awake mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8631f003d170479bbc1fd94094ebcd1e
work_keys_str_mv	AT mohammadmoeini cerebraltissuepo2responsetotreadmillexerciseinawakemice AT christophecloutiertremblay cerebraltissuepo2responsetotreadmillexerciseinawakemice AT xueconglu cerebraltissuepo2responsetotreadmillexerciseinawakemice AT ashokkakkar cerebraltissuepo2responsetotreadmillexerciseinawakemice AT fredericlesage cerebraltissuepo2responsetotreadmillexerciseinawakemice
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Cerebral tissue pO2 response to treadmill exercise in awake mice

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