Internetwork connectivity of molecular networks across species of life

Abstract Molecular interactions are studied as independent networks in systems biology. However, molecular networks do not exist independently of each other. In a network of networks approach (called multiplex), we study the joint organization of transcriptional regulatory network (TRN) and protein–...

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Autores principales:	Tarun Mahajan, Roy D. Dar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8632c2f104de4398b88d3b6b0283bd84
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spelling	oai:doaj.org-article:8632c2f104de4398b88d3b6b0283bd842021-12-02T14:12:08ZInternetwork connectivity of molecular networks across species of life10.1038/s41598-020-80745-92045-2322https://doaj.org/article/8632c2f104de4398b88d3b6b0283bd842021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80745-9https://doaj.org/toc/2045-2322Abstract Molecular interactions are studied as independent networks in systems biology. However, molecular networks do not exist independently of each other. In a network of networks approach (called multiplex), we study the joint organization of transcriptional regulatory network (TRN) and protein–protein interaction (PPI) network. We find that TRN and PPI are non-randomly coupled across five different eukaryotic species. Gene degrees in TRN (number of downstream genes) are positively correlated with protein degrees in PPI (number of interacting protein partners). Gene–gene and protein–protein interactions in TRN and PPI, respectively, also non-randomly overlap. These design principles are conserved across the five eukaryotic species. Robustness of the TRN–PPI multiplex is dependent on this coupling. Functionally important genes and proteins, such as essential, disease-related and those interacting with pathogen proteins, are preferentially situated in important parts of the human multiplex with highly overlapping interactions. We unveil the multiplex architecture of TRN and PPI. Multiplex architecture may thus define a general framework for studying molecular networks. This approach may uncover the building blocks of the hierarchical organization of molecular interactions.Tarun MahajanRoy D. DarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tarun Mahajan Roy D. Dar Internetwork connectivity of molecular networks across species of life
description	Abstract Molecular interactions are studied as independent networks in systems biology. However, molecular networks do not exist independently of each other. In a network of networks approach (called multiplex), we study the joint organization of transcriptional regulatory network (TRN) and protein–protein interaction (PPI) network. We find that TRN and PPI are non-randomly coupled across five different eukaryotic species. Gene degrees in TRN (number of downstream genes) are positively correlated with protein degrees in PPI (number of interacting protein partners). Gene–gene and protein–protein interactions in TRN and PPI, respectively, also non-randomly overlap. These design principles are conserved across the five eukaryotic species. Robustness of the TRN–PPI multiplex is dependent on this coupling. Functionally important genes and proteins, such as essential, disease-related and those interacting with pathogen proteins, are preferentially situated in important parts of the human multiplex with highly overlapping interactions. We unveil the multiplex architecture of TRN and PPI. Multiplex architecture may thus define a general framework for studying molecular networks. This approach may uncover the building blocks of the hierarchical organization of molecular interactions.
format	article
author	Tarun Mahajan Roy D. Dar
author_facet	Tarun Mahajan Roy D. Dar
author_sort	Tarun Mahajan
title	Internetwork connectivity of molecular networks across species of life
title_short	Internetwork connectivity of molecular networks across species of life
title_full	Internetwork connectivity of molecular networks across species of life
title_fullStr	Internetwork connectivity of molecular networks across species of life
title_full_unstemmed	Internetwork connectivity of molecular networks across species of life
title_sort	internetwork connectivity of molecular networks across species of life
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8632c2f104de4398b88d3b6b0283bd84
work_keys_str_mv	AT tarunmahajan internetworkconnectivityofmolecularnetworksacrossspeciesoflife AT royddar internetworkconnectivityofmolecularnetworksacrossspeciesoflife
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Internetwork connectivity of molecular networks across species of life

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